ACTIVITIES REPORT
REGISTRY OF TUMORS IN LOWER ANIMALS: 1978 SUPPLEMENT
JOHN C. HARSHBARGER, DIRECTOR
PREPARED FOR DISTRIBUTION BY:
REGISTRY OF TUMORS IN LOWER ANIMALS NATIONAL MUSEUM OF NATURAL HISTORY ROOM W216-A
SMITHSONIAN INSTITUTION WASHINGTON, D.C. 20560
Ml Z 1987
CONTENTS
OVERVIEW . 1
REFERENCE LIBRARY . 4
PAPERS SINCE 1977 . 4
SELECTED ACTIVITIES IN 1978 . •. . 5
PERSONNEL . 7
ACCESSIONS . 8
INDEX OF NEOPLASTIC AND HYPERPLASTIC LESIONS - ANIMAL GROUP - AND RTLA NUMBER . 30
PHYLOGENETIC INDEX . 32
INDEX OF SPECIMENS BY SCIENTIFIC AND COMMON NAMES . 35
CONTRIBUTORS . 41
TEAR OUT ACCESSION SHEET . Last page
Smithsonian Institution Washington, D.C. 1979
OVERVIEW
The Registry of Tumors in Lower Animals (RTLA) facilitates the study of neoplasms and related disorders in invertebrate and poikilo- thermic vertebrate animals by serving as a specimen depository, a diag¬ nostic center, an information center, and a research group.
Two hundred three accessions (many with multiple specimens) from 13 countries were entered into the Registry’s permanent collection in 1978. As shown in Table 1, nearly one-half were neoplasms which oc¬ curred, in decreasing numbers, in bony fish, reptiles and mollusks (same number) , amphibians , sharks and arthropods (same number) .
TABLE 1
Distribution of lesions among specimens accessioned
|
Phylo¬ genetic group |
Type of disease |
||||
|
Neo¬ plastic |
Non-neo- plastic |
Undeter¬ mined |
Total |
||
|
Reptile |
8 |
16 |
0 |
24 |
(12%) |
|
Amphibian |
6 |
9 |
0 |
15 |
(7%) |
|
Bony fish |
65 |
66 |
2 |
131 |
(65%) |
|
Shark |
1 |
5 |
0 |
6 |
(3%) |
|
Mollusk |
8 |
14 |
1 |
23 |
(11%) |
|
Arthropod |
1 |
1 |
0 |
2 |
(1%) |
|
Total |
83 (41%) |
117 (58%) |
3 (1%) |
203 |
(100%) |
|
Percent of those diagnosed |
(42%) |
(58%) |
Probably the most significant advance of the year was the demonstra¬ tion that the ”x-cells" in parabranchial lesions of cod, and by extrap¬ olation, in the skin lesions of various flatfish (RTLA 2039), goby (RTLA 1897, 2023-2025, 2031, 2033), and other fish species (RTLA 2000) have mitoses and other features which are atypical for vertebrates but are
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consistent for amebae (Dawe, C. J. , J. Bagshaw, and C. M. Poore. Amebic Pseudotumors in Pseudobranchs of Pacific cod, Gadus macrocephalus . Proc. 70th Annu. Meet. Am. Assoc. Cancer Res., 245, 1979J. thus, *'x-ceir' tumors are parasitic lesions, not neoplasms as previously reported. This explains certain long recognized non-neoplastic features of these lesions such as negative Feulgen reaction by "x-cells" and occasional granuloma¬ tous reaction to them. It also provides an explanation for the incon¬ sistent results of attempts to correlate their occurrence with pollution. Future workers will need to differentiate the amebic "x-cell" adenoma¬ like and papilloma- like lesions from true epithelial neoplasms of Osteichthyes such as papilloma in red drum (RTLA 1904 from Allyn Johnson) , white sucker (RTLA 1907 from John Hnath) , and koi carp (RTLA 1901 from Harold Wolf) . So far amebic "x-cells" are unknown from papillary le¬ sions in any non-bony fish species such as fibropapilloma in green sea turtles (RTLA 1856, 1883 from George Balazs) and epidermal papilloma in a green lizard (RTLA 1917 from Edward Elkan) . This lizard papilloma did contain virus- like nuclear inclusions, however.
Among the interesting and significant accessions were five cases of hepatocellular carcinoma in Atlantic tomcod from the Hudson River con¬ tributed by Charlie Smith (RTLA 1868-1872). The Hudson is heavily pol¬ luted by polynuclear aromatic hydrocarbons (PAH's). PAH's in fish are chiefly modified for excretion by liver enzymes with the presumed pro¬ duction of activated intermediates which are carcinogenic. Fish liver cancer has been experimentally induced by exposure to a number of PAH's known to be carcinogenic in rodents. These observations support the hypothesis that these tomcod carcinomas are indicative of carcinogenic PAH's in their environment.
The first and only known liver neoplasm in cartilaginous fish was a well-differentiated hepatocellular adenoma in a stingray (RTLA 1851). This specimen, and two other Chondrichthyes contributed by Prince Masahito (RTLA 1852, 1853), also had thyroid hyperplasia. Additionally, thyroid hyperplasia was seen in an Osteichthyes --a flagfish from Virginia Snarski (RTLA 1952) .
A valuable group of 40 accessions (RTLA 2001-2040) was received from the Japanese Registry of Tumors in Poikilothermic Animals courtesy of Dr. Ikuo Kimura and Dr. Masao Ito. Among these were ameloblastoma in salmon, hepatocellular neoplasms in various salmonids, ovarian neo¬ plasms in carp, melanophoroma in croaker and rainbow trout, nephroblas¬ toma in rainbow trout and Japanese eel, adenomatous stomach polyps in salmon, fibroma in walleye pollack, retinoblastoma in green swordtail and meningioma in Permat ochr omi s kribensis.
In addition to the two central nervous system (CNS) neoplasms from the Japanese tumor registry, an invasive esthesioneuroepithelioma near the lateral line of a goldfish (RTLA 1931 from Harold Wolf) may be the first CNS tumor arising from the vagus nerve. Neuroblastoma in platy- fish/swordtail hybrids (RTLA 1930 from M. Schwab) were induced by N- Methyl-N-Nitrosourea.
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Peripheral nerve neoplasms, in addition to those from the Japanese tumor registry, include neurilemmoma in goldfish (RTLA 1889 from John Carney) and freshwater drum (RTLA 1891 from John Black) .
Pigment cell tumors included an invasive melanophoroma (RTLA 1847 from Bill Ribelin) and a non- invasive melanophoroma (RTLA 1951 from John Comick) in brown bullhead, an erythrophoroma in a goldfish (RTLA 1875 from Prince Masahito) , multiple melanophoroma in Mexican axolotl (RTLA 1886 from Veniamin Khudoley and V. Eliseev) and a xanthoma in a gopher snake (RTLA 1955 frcan Michael Ryan) . A melanophoroma in an Atlantic croaker (RTLA 1988 from Walter Kandrashoff) had a histologic appearance similar to, but less extensive than pigmented lesions in the glue croaker (RTLA 2003, 2008, 2027) from the Japanese tumor registry and the gulf croaker (RTLA 1708, 1709) from Alan Meams in 1977. Dr.
Ikuo Kimura now calls these melanotic neurilemmoma.
A lymphosarcoma frcan a South African clawed frog (RTLA 1996) was received from R. Verhoeff-de Fremery. This, and a similar previous case from Dr. Verhoeff-de Fremery (RTLA 1769) are especially significant because they are composed of expansive populations of uniform lymphoid cells presenting a clear-cut neoplastic picture. Some earlier reports of lymphosarcoma in this species were complicated by being composed of mixed cells including many histiocytes and containing acid- fast bacteria.
Other hematopoietic neoplasms were in medaka (RTLA 1850 from Prince Masahito), black crappie (RTLA 1863, 1864 from John Hnath) , roach (RTLA 1878 from David Bucke) , Burmese tortoise (RTLA 1879, 1880 from Sandra Emanuelson) , reticulate python (RTLA 1960 from A. Heldstab) , European flat oyster (RTLA 1855 from H. Grizel; RTLA 1940-1944, 1946 from George Balouet) and Pacific oyster (RTLA 1945 from George Balouet) .
Reproductive system tumors include a genetically controlled ovarian neoplasm in a fruit fly (RTLA 1890 from Bob King) which is transplantable to wild strains where it invades normal gonad. An organoid gonad neo¬ plasm in a goldfish/carp hybrid (RTLA 1893 from John Black) resembles a gonadoblastoma with some sertoli cell differentiation.
Gonnective tissue tumors include a lipoma in a little tunny (RTLA 1922 from Walter Kandrashoff) , a fibrolipoma in a white sturgeon (RTLA 1999 from Glint Stockley) , a fibroma in a Pacific cutlassfish (RTLA 1854 from Prince Masahito) and in a brown trout (RTLA 1884 from Nelson Boustead) , a dermal fibrosarcoma in a finescale menhaden (RTLA 1848 from Allyn Johnson) , a dermal fibromyxosarcoma in a ribbed newt (RTLA 1873 from W. Janisch and Th. Schmidt) , and a fibroma in the lung of a green sea turtle (RTLA 1856 from George Balazs) .
Excretory system neoplasms included a metastatic renal adenocar¬ cinoma in the leopard frog (RTLA 1874 from Bill Duryee) , nephroblastoma in rainbow trout (RTLA 1985 from Gharlie Smith; RTLA 2011, 2015 from Japanese tumor registry) and the first known nephroblastoma in an eel (RTLA 2032 from the Japanese tumor registry) .
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Additionally, there were adenocarcinoma in the gut of a giant toad (RTLA 1921 from Alan Herron) and in a koi carp (RTLA 1939 from Sharon Daspit) , transitional cell carcinoma probably of olfactory epithelium in a yellow rat snake (RTLA 1937 from Bob Sauer) , and skeletal osteoma in a silver trevally (RTLA 1984) from B. Munday.
Interesting, non -neoplastic lesions included polycystic kidney in New Zealand goldfish (RTLA 1923 from T. Dodgshun; RTLA 1992 from Nelson Boustead) , encephalocele in brown trout (RTLA 1899 from Philip Economon) , assorted skeletal ancmalies in fish from Biscayne Bay from Walter Kandrashoff, a series of teratoid anomalies in lake trout (RTLA 1961- 1980) , apparent chemical induced gill hyperplasia in white sucker (RTLA 1861 from John Hnath) , and oysters with rickettsial inclusions (RTLA 1838-1846) from Sara Otto.
REFERENCE LIBRARY
Approximately 213 papers were added to the comprehensive library on neoplasms in lower animals bringing the total to 3,723. Except for re¬ cent acquisitions and articles that need to be translated, all papers have been abstracted by selected key words and computerized.
PAPERS SINCE 1977
Squire, R. A., D. G. Goodman, M. G. Valerio, T. Fredrickson, J. D. Strandberg, M. H. Levitt, C. H. Lingeman, J. C. Harshbarger, and C. J. Dawe. Tumors. In: Pathology of Laboratory Animals, Vol. 2, K. Benirschke, F. M. Gamer, and tT C. Jones (ed.) , pp. 1051-1283. (Springer-Verlag, New York 1978).
Harshbarger, J. C. , S. V. Otto, and S. C. Chang. Proliferative Dis¬ orders in Crassostrea virginica and Mya arenaria from the Chesapeake Bay and Intranuclear Virus -like Inclusions in I^a arenaria with Germinomas from a Maine Oil Spill Site. Haliotis (in press) .
Otto, S. V., J. C. Harshbarger, and S. C. Chang. Status of Selected Uni¬ cellular Eucaryote Pathogens, and Prevalence and Histopathology of In¬ clusions Containing Obligate Procaryote Parasites, in Commercial Bi¬ valve Mollusks from Maryland Estuaries. Haliotis (in press).
Harshbarger, J. C. and J. A. Couch. A Symposium on Neoplasms in Inverte¬ brates: Highlights and Reflections. Proceedings of the VI th Interna¬ tional Colloquium on Invertebrate Pathology and the Xlth Annual Meeting of the Society for Invertebrate Pathology, September 11-17, 1978, Prague, Czechoslovakia (in press) .
Harshbarger, J. C. Neoplasms in Zoo Poikilotherms Emphasizing Cases in
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the Registry of Tumors in Lower Animals, Proceedings of the Symposium on the Comparative Pathology of Zoo Animals, October 2-4, 1978, Washington, D. C. Smithsonian Institution Press (in press).
SELECTED ACTIVITIES IN 1978
1. Research activities:
a. Studied, diagnosed, and described for the files approximately 200 cases of diseases in cold-blooded vertebrates and inverte¬ brates .
b. Collaborated with Karen L. Hoover (National Cancer Institute) and Sing C. Chang on the study of nuclear inclusions in gang¬ lion cells of minnows from the Ohio River.
c. Collaborated (in various combinations) with Sing C. Chang,
Sara V. Otto (Maryland Department of Natural Resources,
Oxford, Md.), Paul P. Yevich (U.S. Environmental Protection Agency, Narragansett , R.I.), and Leslie A. Page (U.S. Depart¬ ment of Agriculture, Ames, Iowa), on the Incidence, distri¬ bution, cellular structure, fine structure, cell culture, immunological characterizations of 7 chlamydia, rickettsia, and mycoplasma parasites in 4 species of bivalve mollusks (Crassostrea virginica, Mya arenaria, Mytilus edulis, and Mercenaria mercenariay.
d. Collaborated with Sing C. Chang and Peter H. Wolf (New South Wales State Fisheries, Sydney, Australia) on the fine struc¬ ture of papillary epitheliomas of the mantle in the Austra¬ lian rock oyster, Crassostrea commercialis .
e. Collaborated with Sing C. Chang, Clyde J. Dawe (National Cancer Institute), and Louis E. DeLanney (Bar Harbor, Me.)
on the fine structure of mastocytomas in the axolotl, Amby stoma mexicanum.
f. Collaborated with Sing C. Chang and George H. Balazs (University of Hawaii at Manoa) on the fine structure of fibropapillomas in the green sea turtle , Chelonia mydas .
g. Collaborated with Sing C. Chang, John Hurst (Maine Department of Marine Resources, West Boothbay Harbor, Me.), and Edward S. Gilfillan (Bowdoin College, Brunswick, Me.) on a study to determine if germinomas in the soft -shell clam, Mya arenaria , from an oil spill site were caused by hydrocarbons in the en¬ vironment and to determine if nuclear inclusions in the tumor cells are virus.
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2. Other activities:
a. Served as a member o£ the planning committee for the Symposium on the Comparative Pathology of Zoo Animals held on October 2-4, 1978, at the National Zoological Park, Washington, D. C.
b. Added, abstracted, and computerized, with staff help, over 200 reprints to the Registry’s library on tumors in lower animals.
c. Served as a member of the editorial board of the "Journal of Fish Diseases".
d. Served as a member of the Permanent Program Committee of the Society for Invertebrate Pathology.
e. Served as Vice President of the Washington, D. C. Chapter of Sigma Xi.
f. Took a National Institutes of Health evening course on virology.
g. Reviewed manuscripts for the "Journal of the National Cancer Institute," "Cancer Research," "Journal of Fish Diseases," "Science," and the "Journal of the Fisheries Research Board of Canada," and also reviewed research proposals for the National Science Foundation.
3. Lectures and seminars:
a. Moderated the module, "Histopathology of Fish and Shellfish," and presented the paper, "Histopathology of Selected Fish Tu¬ mors," at the 3rd Annual Eastern Fish Health Workshop on May 23 and 24, 1978, at Auburn University, Auburn, Alabama.
b. Attended the 1978 Annual Wildlife Disease Association Con¬ ference and gave a paper on neoplasia in reptiles on August 1-4, 1978.
c. Gave a seminar, "The Role of Comparative Medicine in Cancer Research," to veterinary students at the National Institutes of Health on August 16, 1978.
d. Collaborated with John A. Couch (U.S. Environmental Protection Agency, Gulf Breeze, Florida) on organizing, chairing, and editing the proceedings of the Symposium on Neoplasms in In¬ vertebrates at the VI th International Colloquium on Inverte¬ brate Pathology and the Xlth Annual Meeting of the Society
for Invertebrate Pathology on September 11-17, 1978, in Prague, Czechoslovakia.
e. Attended the Symposium on the Comparative Pathology of Zoo Ani¬ mals on October 2-4, 1978, at the National Zoological Park,
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Washington, D. C. , and presented the paper ^ ’’Neoplasms in Zoo Poikilotherms Bnphasizing Cases in the Registry o£ Tumors in Lower Mimals”.
PERSONNEL
The Project Officer for the contract is Dr. Clyde J. Dawe, Head, Comparative Oncology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20209.
The Principal Investigator for the contract is Dr. W. Duane Hope, Chairman, Department of Invertebrate Zoology, National Museum of Natural History, Smithsonian Institution, Washington, D. C. , 20560.
The Staff of the Registry is as follows:
|
John C. Harshbarger, Ph.D. |
- Director |
|
Sing Chen Chang, Ph.D. |
- Electron Microscopist |
|
Phyllis M. Schellenger, B. S. |
- Registrar |
|
Linda J. Cullen, B. A. |
- Histopathology Technician |
|
Judith E. Foster, B. S. |
- Research Assistant |
|
Marilyn S. Slatick, B. S. |
- Research Assistant |
ACCESSIONS
RTLA 1838. American oyster, Crassostrea virginica
Material: One paraffin block; pathology report
Habitat: Chesapeake Bay: Fishing Bay/Duck Island
Diagnosis: Procaryote cytoplasmic inclusion: stomach epithelium;
extensive infestation by Bucephalus cuculus Submitter: S. V. Otto
RTLA 1839, 1840. Material : Habitat : Diagnosis : Submitter :
American oyster, Crassostrea virginica One paraffin block and pathology report each Chesapeake Bay: Fishing Bay/Duck Island Procaryote cytoplasmic inclusion: digestive diverticulum S. V. Otto
RTLA 1841. American oyster, Crassostrea virginica
Material: One paraffin block; pathology report
Habitat: Chesapeake Bay: Fishing Bay/Duck Island
Diagnosis: Procaryote cytoplasmic inclusion: gut epithelium Submitter: S. V. Otto
RTLA 1842, 1843. Material : Habitat : Diagnosis : Submitter:
American oyster, Crassostrea virginica One paraffin block and pathology report each Chesapeake Bay: Fishing Bay/Duck Island Procaryote cytoplasmic inclusion: digestive diverticulum S. V. Otto
RTLA 1844, 1845. Material : Habitat : Diagnosis :
Submitter :
American oyster, Crassostrea virginica One paraffin block and pathology report each Chesapeake Bay: Fishing Bay/Duck Island "Ovacystis" (Papova virus) and procaryote cytoplasmic inclusion: gonad S. V. Otto
RTLA 1846. American oyster, Crassostrea virginica Material: One paraffin block; pathology report
Habitat: Chesapeake Bay: Fishing Bay/Duck Island
Diagnosis: Procaryote cytoplasmic inclusion: digestive diverticulum Submitter: S. V. Otto
RTLA 1847. Brown bullhead, Ictalurus nebulosus
Material :
Habitat : Diagnosis : Submitter :
Variously sized pieces of skin and subcutaneous tissue overlain with black growths; 1 black and white photo¬ graph
Lake Waubesa, Wisconsin Invasive melanophoroma W. E. Ribelin
RTLA 1848. Finescale menhaden, Brevoortia gunteri
Material: Section of body wall with external knobby growth
Habitat: National Marine Fisheries Service Laboratory, Port
Aransas, Texas
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RTLA 1848 (contd.)
Diagnosis : Dermal fibrosarcoma Submitter: A. G. Johnson
RTLA 1849. Zebra- tailed lizard, Callisaurus draconoides Material: Piece of liver tissue
Habitat: San Bernardino County, California
Diagnosis: Parasitic granulomas containing probable larval trema- todes
Submitter: S. D. Busack
RTLA 1850. Medaka, Qryzias latipes
Material: One microslide ; 1 black and white photographs
Habitat: Aquarium, Cancer Institute, Tokyo, Japan
Diagnosis: Well-differentiated lymphoma Submitter: Prince Masahito Hitachi
RTLA 1851. Stingray, Dasyatis akajei
Material: Five microslides of liver and thyroid tissue; 3 black
and white photographs Habitat: Ueno Zoo Aquarium, Japan
Diagnosis: Slow- growing , well-differentiated hepatoma; adenomatous goiter versus a follicular adenoma Submitter: Prince Masahito Hitachi
RTLA 1852. Shark, Triakis scyllia
Material: One microslide of thyroid tissue;
photograph
Habitat: Ueno Zoo Aquarium, Japan
Diagnosis: Thyroid hyperplasia Submitter: Prince Masahito Hitachi
1 black and white
RTLA 1853. Stingray, Dasyatis akajei
Material :
Habitat : Diagnosis : Submitter :
Two microslides o photographs
Ueno Zoo Aquarium, Japan Endemic (colloid) goiter Prince Masahito Hitachi
thyroid tissue; 2 black and white
RTLA 1854. Pacific cutlassfish, Trichiunis lep turns
Material : Two microslides ; 2 black and white photographs
Habitat: Tokyo Central Wholesale Market -- captured off coast
of Chiba prefecture. Pacific Ocean Diagnosis: Fibroma: within mid trunk musculature Submitter: Prince Masahito Hitachi
RTLA 1855. European flat oyster, Ostrea edulis Material: Two microslides
Diagnosis: Poorly differentiated sarcoma of undetermined origin Submitter: H. Grizel
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RTLA 1856. Green turtle, Chelonia mydas
Material: Tissue: front flippers with associated pectoral muscu¬
lature; complete pelvic section including hind flippers and tail; head, neck, heart, and section of lung Habitat: Kaneohe Bay, Island of Oahu, Hawaii
Diagnosis: Fibropapilloma of skin; fibroma of lung Submitter: G. H. Balazs
RTLA 1857. African bullfrog, Pyxicephalus adspersus Material: Digit with multiple nodular growths
Habitat: Reptile House, San Antonio Zoological Gardens and
Aquarium, San Antonio, Texas
Diagnosis: Osteomyelitis associated with bone destruction and prickle cell hyperplasia Submitter: K. C. Fletcher
RTLA 1858-1860. Material : Habitat : Diagnosis :
Submitter :
Carp , Cyprinus carpio
Three tissue samples each: liver, gill, and kidney Kalamazoo River at Plainwell Damsite, Otsego, Michigan Extensive gill hyperplasia probably due to chemical pollution resulting in asphyxiation; liver and kidney tissue "normal"
J. G. Hnath
RTLA
1861. White sucker, Catostomus commersoni Material: Two tissue samples: gill and liver
Habitat: Kalamazoo River at Plainwell Damsite, Otsego, Michigan
Diagnosis: Extensive gill hyperplasia probably due to chemical pollution resulting in asphyxiation; liver tissue "normal"
Submitter: J. G. Hnath
RTLA 1862. Rainbow trout, Salmo gairdneri
Material: Two pieces of tissue; one microslide
Diagnosis : Hemangioendotheliosarcoma Submitter: C. E. Smith
RTLA 1863, 1864. Material : Habitat : Diagnosis :
Submitter :
Black crappie , Pomoxis nigromaculatus Two cassettes each, containing tissue Cornwall Lake, Van Buren County, Michigan Probable hematopoietic sarcoma; tissue too autolyzed for a definitive diagnosis J. G. Hnath
RTLA 1865. California (?) needlefish, Strongylura exilis (?)
Material: Head with multiple growths along the lower jaw; gill
with scars; 2, 35 mm color transparencies Habitat: Shelter Island, San Diego Bay, California
Diagnosis: Exuberant, excavating, multifocal bacterial granuloma Submitter: G. E. Cosgrove
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RTLA 1866. White shark, Carcharodon carcharias
Material : Six microslides; 13 black and white photographs
Habitat: Off Ventura County, California, 20 miles NNW Santa
Barbara Islands
Diagnosis: Bacterial infection and chronic inflammatory reaction to probable injury Submitter: R. W. Warner
RTLA 1867. Yellowstone cutthroat trout, Salmo dark! Material: One microslide
Habitat: State Fish Hatchery, Big Timber, Montana
Diagnosis: Hemangioma Submitter: C. E. Smith
RTLA 1868, 1869. Material :
Habitat : Diagnosis : Submitter : Reprint :
RTLA 1870, 1871. Material :
Habitat : Diagnosis : Submitter: Reprint :
Atlantic tomcod, Microgadus tomcod Five microslides (RTLA 1868) ; 2 pieces of liver tissue each
Hudson River, Buchanan, New York Hepatomas and hepatocellular carcinomas C. E. Smith
Smith, Charlie E. , Thomas H. Peck, Ronald J. Klauda, and James B. M:Laren. Hepatomas in Atlantic Tomcod (Microgadus tomcod) Collected in the Hudson River Estuary New York. J. Fish Dis. (expected in Vol. 2, July 1979).
Atlantic tomcod, Microgadus tomcod Three and 2 microsl ides respect ively ; 2 pieces of liver tissue each Hudson River, Buchanan, New York Hepatomas and hepatocellular carcinomas C. E. Smith (See RTLA 1868, 1869)
RTLA 1872. Atlantic tomcod, Microgadus tomcod
Material : Habitat : Diagnosis :
Submitter : Reprint :
Three microslides; 2 pieces of liver tissue Hudson River, Buchanan, New York
Liver lesions: hepatocellular carcinomas; lesion near dorsal fin: exuberant fibroblastic reaction adjacent to and surrounding 2 granulomas probably due to injury C. E. Smith (See RTLA 1868, 1869)
RTLA 1873. Ribbed newt, Pleurodeles waltlii
Material: Three microslides; 5 black and white photographs;
5 electron photomicrographs Habitat: Laboratory bred
Diagnosis: Dermal fibromyxo sarcoma Submitter: W. Janisch and Th. Schmidt
RTLA 1874. Leopard frog, Rana pipiens Material: Six microslides
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RTLA 1874 (contd.)
Diagnosis: Luckd renal adenocarcinoma metastatic to liver Submitter: W. R. Duryee
RTLA 1875. Goldfish, Carassius auratus
|
Material : Habitat : Diagnosis: Submitter : Reprint : |
Seven microslides: 1, 35 mm color trarisparency Privately owned ponds Erythrophoroma Prince Masahito Hitachi Ishikawa, Takatoshi, Prince Masahito, Jiro Matsumoto, and Shozo Takayama. f4)rphologic and Biochemical Characterization of Erythrophoromas in Goldfish (Carassius auratus). J. Natl. Can- cer Inst., Q: 1461-1470. 1978. |
RTIA 1876. Milkfish, Chanos chanos
|
Material : |
Section of ventricle and bulbus arteriosus |
|
Habitat : Diagnosis : Submitter : |
area; "normal" specimen Pearl Harbor, Oahu, Hawaii Possible hematoma due to vascular accident A. C. Smith |
RTLA 1877. Milkfish, Chanos chanos
|
Material : Habitat : Diagnosis: Submitter: |
Portion of ventral aorta; "normal" specimen Pearl Harbor, Oahu, Hawaii Blood clot formed in situ A. C. Smith |
RTLA 1878. Roach, Rutilus rutilus
|
Material : |
Two microslides |
|
Habitat : Diagnosis : Suhnitter : |
Warm water effluent from power station Malignant lymphoma D. Bucke |
|
RTLA 1879, 1880. Material : Habitat : Diagnosis : |
Burmese tortoise One microslide each Pet; California Hematopoietic cell neoplasm of undetermined |
|
Submitter : |
cell type S. Emanuelson |
RTIA 1881. Leopard frog, Rana pipiens Material: Four microslides
Habitat: Mumley County, Alburg, Vermont
Diagnosis: Multiple hepatic (probably bacterial) granulomas Submitter: W. R. Duryee
RTLA 1882. Mexican axolotl, Mbystoma mexicanum
Material: Twin, coalescing, cyst- like lesions in body wall
Diagnosis: Retroperitoneal, infectious, abscess-like granuloma Submitter: R. Verhoeff-de Fremery
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RTLA 1883. Green turtle, Chelonia mydas
Material: Biopsies from tumor surface and surface of "stalk" or
attachment site of tumor
Habitat: Hawaiian Islands then held in captivity for 5+ years
Diagnosis: Fibropapilloma Submitter: G. H. Balazs
RTLA 1884. Brown trout, Salmo trutta
Material: A large, white, firm growth with a hollow core, divided
into 3 portions; viscera (attachment to growth severed); 1, 35 mm color transparency Habitat: Glenarrife, Raikia River, New Zealand
Diagnosis : Fibroma Submitter: N. Boustead
RTLA 1885. Painted turtle, Chrysei Material :
mv:
Ih
s picta
Gross specimen with head and shell removed; large, dark red growth on ventral surface of bladder Habitat: Wisconsin
Diagnosis: Hematoma associated with multiple granulomas in response to a worm parasite -- probably nematode Submitter: V. Lance
RTLA 1886. Mexican axolotl, Ambystoma mexicanum
Material: Two microslides; 1 black and white print of gross
specimen
Diagnosis: Miltiple melanophoromas Submitter: V. V. Khudoley and V. V. Eliseev
RTLA 1887. Smokey jungle frog, Leptodactylus pentadactylus Material: Three microslides
Habitat: Seneca Park Zoo, Rochester, New York
Diagnosis: Generalized leukemoid reaction secondary to acute bacterial (coccal) endocarditis Submitter: A. J. Herron
RTLA 1888. Rainbow trout, Salmo gairdneri
Material: Liver; kidney and spleen with nodules; pancreas;
1, 35 mm color transparency Habitat: Lake Taupo, New Zealand
Diagnosis: Tissue too autolyzed for diagnosis Submitter: N. Boustead
RTLA 1889. Goldfish, Carassius auratus Material: Two microslides
Diagnosis: Neurilemmoma or possibly some type of pigment cell tumor
Submitter: J. Carney
RTLA 1890. Drosophila melanogaster Material: One microslide
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RTLA 1890 (contd.)
Habitat: Laboratory reared (?)
Diagnosis: Ovarian neoplasm due to a mutation Submitter: R. C. King
Reprint: King, Robert C. , Mary Bahns, Richard Horowitz, and
Paloma Larramendi. A Mutation that Affects Female and Male Germ Cells Differentially in Drosophila melanogaster Meigen (Diptera : Drosophilidae) .
Inti. J. Insect Morphol. Embryol., 7: 359-376. 1978.
RTLA 1891. Freshwater drum, Aplodinotus grunniens Material : One microslide
Habitat: Buffalo Harbor, Buffalo, New York
D iagno sis: Neur i 1 emmoma Suhnitter: J. J. Black
Reprint: Black, John J. , Margaret Holmes, Charles Wenner,
and William Zapisek. Carcinogenesis Studies in the Western New York Great Lakes Aquatic Environment, (abstr.) .
RTLA 1892. Carp, Cyprinus carpio Material: Three microslides
Habitat: Buffalo River, New York
Diagnosis: Dystrophy of the testis Submitter: J. J. Black Reprint: (See RTLA 1891)
RTLA 1893. Goldfish/carp hybrid, Caras sius auratus x Cyprinus carpio Material: Four microslides; 1 black and white print
Habitat: Niagara River near Strawberry Island, New York
Diagnosis: Organoid gonadal tumor (gonadoblastoma ?)
Submitter: J. J. Black Reprint: (See RTLA 1891)
RTLA 1894. Crevalle jack, Caranx hippos
Material: A piece of body wall with a growth in the skeletal
muscle protruding into the visceral cavity Habitat: Miamarina, Miami, Florida
Diagnosis: Protozoan granuloma Submitter: W. Kandrashoff
RTLA 1895. Crevalle jack, Cara^ hippos
Material: Caudal fin with growth immediately posterior to fork
Habitat: Miamarina, Miami, Florida
Diagnosis: Protozoan granuloma Submitter: W. Kandrashoff
RTLA 1896. Pinfish, Lagodon rhomboides
Material: Tissue samples from 14 fish showing scale, fin, and
jaw anomalies
Habitat: Miamarina, Miami, Florida
RTLA 1896 (contd.)
Diagnosis : Pending Submitter: W. Kandrashoff
-15-
RTLA 1897. Yellowfin goby, Acanthogobius flavimanus
Material: One paraffin block; 1 black and white photograph
|
Habitat : |
Mikawa Bay, facing the Pacific Ocean; situated approximately in the middle of Honshu Island |
|
Diagnosis : Submitter: Reprint : |
Papilloma (amebic "x-cell" pseudotumor) Y. Ito Ito, Y. , I. Kimura, and T. Miyake. Histopathological and Virological Investigations of Papillomas in Soles and Gobies in Coastal Waters of Japan. In: Progress in Experimental Tumor Research, Vol. 20, F. Homburgei , series ed. , Tumors in Aquatic Animals, C. J. Dawe et al., vol. ed. , pp. 86-93 (Karger, Basel 1976). |
RTLA 1898. Lemon shark, Negaprion brevirostris Material : Gross specimen
Diagnosis: "Normal"
Submitter: E. C. McKinney
RTLA 1899. Brown trout, Salmo trutta
|
Material: |
Three gross specimens each with a median dorsal skull protrusion; 2, 35 mm color transparencies; pathology |
|
Habitat: Diagnosis : Submitter: |
report Probably a fish hatchery in St. Paul, Minnesota Encephalocele lesions P. P. Economon |
RTLA 1900. Crevalle jack, Caranx hippos
Material: Five pieces of tissue with multiple growths in skeletal
muscle
Habitat: Miamarina, Miami, Florida
Diagnosis : Protozoan granuloma Submitter: W. Kandrashoff
RTLA 1901. Koi carp, Cyprinus carpio
Material: Gross specimen with multiple lesions concentrated mainly
|
Habitat: Diagnosis : Submitter : |
on the lips, left operculum, and fin rays of all fins; one microslide of tissue from a lip lesion Pet Epidermal papilloma H. Wolf |
RTLA 1902. Yellow sand mussel. Lamps ills anodontoides Material : Gross specimen including both shells
Habitat: Received by contributor from biological supply company
Diagnosis: Bulbous edema associated with inflammation and calcium deposits
Submitter: R. A. Virkar
-16-
RTLA 1903. Axolotl, Ambystoma sp. Material: Cyst-like growth
Diagnosis: Cholecystitis Submitter: R. Verhoe£f-de Fremery
RTLA 1904. Red Material : Habitat:
Diagnosis : Submitter :
drum, Sciaenops ocellata Portion of snout with attached growth Caught off the St. Andrews State Park fishing dock, Panama City, Florida Epidermal papilloma A. G. Johnson
RTLA 1905. Atlantic cod, Gadus morhua Material: One microslide
Diagnosis: Hyperplasia probably due to stimulation of parasites Submitter:. R. A. Murchelano
RTLA 1906. Shove Inose sturgeon, Scaphirhynchus platorynchus Material: Numerous nodular and cyst -like growths
Diagnosis: Multiple teratoid anomalies of the ovary with no evidence of carcinoma Submitter: C. E. Smith
RTLA 1907. IVhite sucker, Catostomus co^mmersoni
Material : Posterior portion of fish with ulcerated
caudal peduncle and bilateral protruding anal region
Habitat: Lake Huron, Grindstone City Harbor
Diagnosis: Epidermal papilloma Submitter: J. G. Hnath
lesion on the "glands" in
RTLA 1908. Rainbow trout, Salmo gairdneri
Material: Three microslides; 3 color prints
Habitat: In the Hagerman Valley near Hagerman, Idaho
Diagnosis: Anomalous hypervascularization of fat lobules.
sibly developmental in origin Submitter: R. A. Busch
pos-
RTLA 1909. Muskellunge, Esox masquinongy
Material: Two cassettes containing tissue from jaw lesion;
3 color prints
Habitat: Bankson's Lake, Van Buren County, Michigan
Diagnosis: Ulcerated acute and chronic inflammations of the der¬ mis and subcutis Submitter: J. G. Hnath
RTLA 1910. Goldfish, Caras sius auratus Material: One paraffin block
Diagnosis: Peritonitis Submitter: E. Elkan
-17-
RTLA 1911. Leopard frog, Rana pipiens Material: One paraffin block
Diagnosis: Gut parasitized by Nematotaenia dispar Submitter: E. Elkan
RTLA 1912. Granite spiny lizard, Sceloporus orcutti Material: One paraffin block
Diagnosis: Congenital polycystic kidney Submitter: E. Elkan
RTLA 1913. Granite spiny lizard, Sceloporus orcutti Material : One paraffin block
Diagnosis: Renal abscesses; septicaemia Submitter: E. Elkan
RTLA 1914. Tessellated water snake, Natrix tessellata Material: One paraffin block
Diagnosis: Hepatic abscesses Submitter: E. Elkan
RTLA 1915. Russell's viper. Viper a russelll Material : One paraffin block
Diagnosis: Accessory spleen Submitter: E. Elkan
RTLA 1916. Monitor lizard, Varanus salvator Material: One paraffin blodk
Diagnosis: Extensive pulmonary fibrosis due to nematodes Submitter: E. Elkan
RTLA 1917. Green lizard, Lacerta viridis Material : Two paraffin blocks
Diagnosis: Epidermal papilloma Submitter: E. Elkan
RTLA 1918. Asian garden snake, Calotes calotes Material: One paraffin block
Diagnosis: Gut parasitized by trematodes Submitter: E. Elkan
RTLA 1919. Asian rat snake, Ptyas korros Material: One paraffin block
Diagnosis: Normal skin demonstrating mucopolysaccharides Submitter: E. Elkan
RTLA 1920. Guppy, Poecilia reticulata Material: Three microslides
Habitat: Experimental animals
Diagnosis: Multiple hepatic granulomas of parasitic and probable bacterial etiology Submitter: S. J. Sherman
-18-
RTLA 1920 (contd.)
Reprint: Sherman, Susan Joy. The Guppy (Poecilia reticulata)
as a Model for Cancer Research . (abs tr . ) .
RTLA 1921. Giant toad, Bufo marinus Material : Two microslides
Diagnosis: Adenocarcinoma of the large intestine; no evidence of metastatic growth in other tissues examined Submitter: A. J. Herron
RTLA 1922. Little tunny, Euthynnus alletteratus Material: Tissue sections from two lesions
Habitat: Caught by charter fishing boat in the Gulf Stream off
Miami Beach, Florida Diagnosis: Lipoma Submitter: W. Kandrashoff
RTLA 1923. Goldfish, Carassius auratus
Material: Whole fish with internal bilateral cyst-like growths
Diagnosis: Polycystic kidney Submitter: T. J. Dodgshun
RTLA 1924. Amazon molly, Poecilia formosa Material: One microslide
Diagnosis: Small cryptogenic granulomas in visceral fat between esophagus and dorsal aorta Submitter: M. J. Peak
RTLA 1925. Leopard frog, Rana pipiens
Material: Partially dissected frog with enlarged liver
Habitat : Vermont
Diagnosis: Hemorrhage -- probably injury related Submitter: V. Lance
RTLA 1926. Leopard frog, Rana pipiens
Material: Decapitated, partially dissected frog; enlarged spleen
from same specimen Habitat : Vermont
Diagnosis: "Normal"
Submitter: V. Lance
RTLA 1927. Painted turtle, Chrysemys picta
Material: Head with grossly enlarged left mastoid region
Diagnosis: Inflammatory, pus-filled cyst, possibly resulting from a bacterial infection of a surface wound Submitter: V. Lance
RTLA 1928. Striped grouper, Grammistes sexlineatus
Material: Four tissue bits : from a lower jaw lesion and bi¬
lateral operculum lesions Habitat: Aquarium
-19-
RTLA 1928 (contd.)
Diagnosis: Epidermal hyperplasia associated with epidermal micro¬ cysts in the dermis Submitter: G. C. Blasiola, Jr.
RTLA 1929. Koi carp, Cyprinus carpio
Material: Microslide of lesion located near caudal fin
Diagnosis: Spindle cell neoplasm of soft tissue; cell type undetermined Submitter: J. Carney
RTLA 1930. Platyfish- swordtail backcross hybrid, Platypoecilus variatus x Xiphophorus helleri x X. helleri BC,
Material: Four photographs
Diagnosis: Neuroblastoma Submitter: M. Schwab
Reprint: Schwab, M. , J. Haas, S. Abdo, M. R. Ahuja, G. Kollinger,
A. Anders, and F. Anders. Genetic Basis of Susceptibility for Development of Neoplasms Following Treatment with N-Methyl-N-Nitrosourea (MNU) or X-rays in the Platy- fish/Swordtail System. Experientia, 34: 780-782. 1978.
Schwab, M. , S. Abdo, M. R. Ahuja, G. Kollinger, A. Anders, F. Anders, and K. Frese. Genetics of Sus¬ ceptibility in the Platyfish/ Swordtail Tumor System to Develop Fibrosarcoma and Rhabdomyosarcoma Fol¬ lowing Treatment with N-Methyl-N-Nitrosourea (MNU) . Z. Krebsforsch. , 301-315. 1978.
RTLA 1931. Goldfish, Caras sius auratus
Material: One microslide; 1 paraffin block
Habitat: Big Bear Lake, San Bemadino County, California
Diagnosis: Invasive esthesioneuroepithelioma, possibly from vagus nerve
Submitter: H. Wolf
RTLA 1932. Pitar morrhuana
Material : One microslide
Habitat: Quonsett Point in Narragansett Bay, Rhode Island
Diagnosis: Procaryote cytoplasmic inclusions; unidentified extra¬ cellular structureless bodies, possibly mineral Submitter: H. Diamond
RTLA 1933. Pitar morrhuana
Material: One microslide
Habitat: Quonsett Point in Narragansett Bay, Rhode Island
Diagnosis: Chronic inflammation to ova resorption and to bac¬ terial infection Submitter: H. Diamond
RTLA 1934. Hard clam, Mercenaria mercenaria
-20-
RTLA 1934 (contd.)
Material: One microslide
Habitat: Collected from sediments near the dock of the Graduate
School of Oceanography, Kingston, Rhode Island Diagnosis: Pending Submitter: H. Diamond
RTLA 1935. Sheepshead minnow, Cyprinodon variegatus
Material: Four microslides of large, whitish nodules scattered
throughout the surface of the fish Habitat: Succotash Marsh, Jerusalem, Rhode Island
Diagnosis: Xenoma -- due to an infestation of protozoan parasites probably microsporida Submitter: T. Le Foley
RTLA 1936. Eastern brook trout, Salvelinus fontinalis
Material: One microslide of liver and kidney tissue
Habitat: Moccasin Creek Hatchery near Sonora, California
Diagnosis: Visceral granuloma Submitter: H. Wolf
RTLA 1937. Yellow rat snake, Elaphe obsoleta
Material: One microslide of growth located in the mouth
Habitat : Pet
Diagnosis: Transitional cell carcinoma Submitter: R. M. Sauer
RTLA 1938. Rainbow trout, Salmo gairdneri Material: One microslide
Diagnosis: Displacement and dysplasia of lens epithelium concomi¬ tant with liquefaction of the crystalline lens Submitter: L. Crutcher
RTLA 1939. Koi Material : Habitat :
Diagnosis : Submitter:
carp , Cyprinus carpio One microslide
Female breeder fish owned by the G. K. Fish Hatchery, California
Invasive adenocarcinoma S. Daspit
RTLA 1940. European flat oyster, Ostrea edulis
Material: Four microslides; collecting data
Habitat: North Breton coast: Paimpol, France
Diagnosis: Hematopoietic neoplasm Submitter: G. Balouet
RTLA 1941. European flat oyster, Ostrea edulis
Material: Four microslides; collecting data
Habitat: South Brittany (Morbihan) : St. Philibert, France
Diagnosis: Hematopoietic neoplasm Submitter: G. Balouet
-21-
RTLA 1942. European flat oyster, Ostrea edulis
Material: Four microslides ; collecting data
Habitat; North Breton coast: Carantec, France Diagnosis; Hematopoietic neoplasm Submitter: G. Balouet
RTLA 1943, 1944. European flat oyster, Ostrea edulis
Material: Four microslides each and collecting data
Habitat: Bay of Brest: Landevennec, France
Diagnosis: Hematopoietic neoplasm Submitter: G. Balouet
RTLA 1945. Pacific oyster, Grassostrea gigas
Material: Four microslides; collecting data
Habitat: Arcachon, France
Diagnosis: Hematopoietic neoplasm Submitter: G. Balouet
RTLA 1946. European flat oyster, Ostrea edulis
Material: Four microslides; collecting data
Habitat: South Brittany (Morbihan) : St. Philibert, France
Diagnosis: Hematopoietic neoplasm Submitter: G. Balouet
RTLA 1947. African sand snake, Psammophis punctulatus Material: Three paraffin blocks
Diagnosis: Huge abscess submucosa of gut; nematode granulomas in submucosa Submitter; E. Elkan
RTLA 1948. Ball snake. Python regius Material : One paraffin block
Diagnosis: Papillary hyperplasia on the mucosa of the gall bladder Submitter: E. Elkan
RTLA 1949. Monitor lizard, Varanus salvator Material : Two paraffin blocks
Diagnosis: Multi- focal, ulcerative, bacterial abscesses of the mouth
Submitter: E. Elkan
RTLA 1950. Boa constrictor
Material: One paraffin block
Diagnosis: Post mortem necrosis Submitter: E. Elkan
RTLA 1951. Brown bullhead, Ictalurus nebulosus
Material: A black, dome- shaped growth; 2 black and white photo¬
graphs
Mack Lake, Kings Gounty, Nova Scotia, Ganada
Habitat :
RTLA 1951 (contd.)
Diagnosis: Melanophoroma Submitter: J. W. Comick
-22-
RTLA 1952. Flagfish, Jordanella floridae
Material: Two whole fish: one "normal" specimen
men with growth protruding from right Habitat: Stock culture, Environmental Research
Duluth, Minnesota Diagnosis : Goiter Submitter: V. M. Snarski
and one speci- operculum Laboratory ,
RTLA 1953. Barred pargo, Hoplopagrus guntheri
Material: Two microslides; 5 color transparencies; right pectoral
fin with attached growth
Habitat: Caught in a tide pool near the village of Puerto
Penasco, Sonora, Mexico
Diagnosis: Inflammatory fibrosis -- etiology unknown Submitter: D. V. Lightner
RTLA 1954. Boa constrictor
Material : Whole specimen
Habitat: Pet; imported from South America
Diagnosis: Septicemia
Submitter: I. Gorman
RTLA 1955. Gopher snake, Pituophis melanoleucus Material : One microslide
Habitat : Pet
Diagnosis : Xanthoma Submitter: M. J. Ryan
RTLA 1956. Goldfish, Caras sius auratus
Material : Paraffin- embedded tissue from a growth on an eye
Hab i t at : Aquarium
Diagnosis: Multicentric granuloma
Submitter: N. Kelly
RTLA 1957. Guppy, Poecilia reticulata
Material : Paraffin-embedded tissue from a growth in the kidney
region
Habitat: Aquarium; home bred
Diagnosis: Traumatic lesion characterized by hemorrhage, muscle atrophy, and inflammation Submitter: N. Kelly
RTLA 1958. Lemon shark, Negaprion brevirostris
Material: Seven fins (caudal and part of a dorsal fin) with ul¬
cerated areas near the tips of each fin from 3 sepa¬ rate shark specimens; one color photograph North Biscayne Bay, Miami, Florida
Habitat :
RTLA 1958 (contd.)
Diagnosis: Pending Submitter: W. Kandrashoff
-23-
RTLA 1959. Ribbed newt, Pleurodeles waltlii
Material: Six microslides; 4 electron photomicrographs; 4 black
and white photographs Habitat : Laboratory bred
Diagnosis: Angiosarcoma Submitter: W. Janisch and Th. Schmidt
RTLA 1960. Reticulate p^hon, ^thon reticulatus
Material: Three microslides o£ intestine, kidney, and liver
Habitat: Basel Zoo, Basel, Switzerland
Diagnosis: Malignant lymphoma Submitter: A. Heldstab
RTLA 1961-1980. Lake trout, Salvelinus namaycush Material: One whole fish each
Habitat: Marquette State Fish Hatchery, Michigan
Diagnosis: Teratoid anomalies; fungus infection of gills Submitter: J. G. Hnath
RTLA 1981. Snail, Olivella sp.
Material: 254 whole animals for disease survey; 98 were histo¬
logically processed
Habitat: Panama Canal (Pacific side)
Diagnosis: Parasitic and bacterial granulomas Submitter: H. W. Kaufman
RTLA 1982. Colorado potato beetle, Leptinotarsa decemlineata Material: Four whole larvae
Habitat: Insect Zoo, National Museum of Natural History,
Smithsonian Institution, Washington, D.C.
Diagnosis: Fungus infection (Ascomycetes)
Submitter: B. Daniels
RTLA 1983. Silver trevally, Caranx sp.
Material : One paraffin block
Diagnosis : Skeletal osteoma Submitter: B. L. Munday
RTLA 1984. Morwong, Cheilodactylus sp. (?) Goniistius sp. (?)
Material : Four microslides
Diagnosis: Intramuscular melanosis Submitter: B. L. Munday
RTLA 1985. Rainbow trout, Salmo gairdneri
Material: Three pieces of tissue from a kidney growth; 4 micro¬
slides
Diagnosis : Nephroblastoma Submitter: C. E. Smith
-24-
RTLA 1986. Weakfish (?) , Cynoscion regius (regal is ?)
Material : One whole fish
Habitat: Pamlico Sound near Swan Island off Cedar Island,
North Carolina Diagnosis: Pending Submitter: F. J. Schwartz
RTLA 1987. Red- spotted newt, Notophthalmus viridescens Material: Ten microslides
Habitat: Pond near Oak Ridge, Tennessee
Diagnosis: Epidermal hyperplasia following carcinogen injection Submitter: J. A. Hightower
RTLA 1988. Atlantic croaker, Micropogon undulatus
Material : Fish head with an amorphous , black pigmented area on
the snout and an eye sunken into the socket Diagnosis : Melanophoroma Submitter: W. Kandrashoff
RTLA 1989. White grunt, Haemulon plumieri Material: Whole fish
Diagnosis: Scale disorientation Submitter: W. Kandrashoff
RTLA 1990. Lake Material :
Habitat: Diagnosis : Submitter:
herring, Coregonus artedii
Two transverse segments of a fish with rust-colored
lesions on the skin
St. Mary's River, Michigan
Inflammation of dermis to bacterial infection J. G. Hnath
RTLA 1991. Boa constrictor
MateriaTT Whole juvenile animal
Habitat: Captive bred; California
Diagnosis: Pending Submitter : I . Gorman
RTLA 1992. Goldfish, Caras sius auratus
Material: Partially dissected specimen with a cyst-like kidney
Habitat: Ornamental pond, Christchurch, New Zealand
Diagnosis: Polycystic kidney Submitter: N. Boustead
RTLA 1993. Macrourid, Coelorinchus australis
Material : Ovary with an attached spherical growth
Habitat: West Coast, South Island, New Zealand
Diagnosis: Granuloma: caused by a septate, sporulating fungus Submitter: N. Boustead
RTLA 1994. Leather j acket (triggerfish) , Cantherhines scaber
Material: Decapitated fish with a lesion involving the skin of
-25-
RTLA 1994 (contd.)
one side of the animal including the caudal peduncle Habitat: Wellington Harbour, New Zealand
Diagnosis: Inflaimnation of cutaneous and subcutaneous tissue; no organisms apparent Submitter: N. Boustead
RTLA 1995. Hard Material :
Habitat : Diagnosis : Submitter:
clam, Mercenaria mercenaria
One microslide of kidney tissue; 1 paraffin block; 1 pathology report Chincoteague Bay
Unidentified parasites in kidney S. V. Otto
RTLA 1996. South African clawed frog, Xenopus laevis
Material: Spherical firm growth with dendriform venation on its
surface; growth was on the spleen Diagnosis : Lymphosarcoma Submitter: R. Verhoeff-de Fremery
RTLA 1997. Pacific pomfret, "Shima-gatsuo," Brama japonica
Material: Piece of body wall with worm-like lesions embedded in
the muscle
Habitat: Okhotsk Sea
Diagnosis: Parasitism by trematodes of the family Didymozoidae Submitter: T. Harada and K. Oishi
RTLA 1998. Sea Material :
Habitat :
Diagnosis :
Submitter :
bass, Holanthias martinicensis Whole specimen with a tear -dropped shaped lesion over- lying and involving the gonad
Off Nicaragua: Oregon Station 6424 (Field Museum of Natural History)
Multiple trematode granulomas in the ovaries, other visceral organs, and the peritoneal cavity F. C. Seyfert
RTLA 1999. White sturgeon, Acipenser transmontanus
Material: Tissue: fatty growth, spleen stalked growth, section
of heart, section of liver; figure; 8 black and white photographs
Habitat: Columbia River near Skamokawa, Washington
Diagnosis: Fibrolipoma Submitter: C. E. Stockley
RTLA 2000. Pacific ocean perch, Sebastes alutus
Material: Whole fish with a growth inside of both opercula
Habitat: Hecate Strait, British Columbia, Canada
Diagnosis: Amebic "x-cell" pseudotumor Submitter: J. Bagshaw
RTLA 2001. Medaka, Oryzias latipes
-26-
RTLA 2001 (contd.)
Material; One microslide Diagnosis: Hepatoma
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2002. Koi carp, Cyprinus carpio Material: Four microslides
Diagnosis: Ovarian tumor (?)
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2003. Glue croaker, Nibea mitsukurii Material : Two microslides
Diagnosis: Malignant melanoma with splenic metastasis Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2004. Salmon, Oncorhynchus masou Material: Three microslides
Diagnosis : Ameloblastoma
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2005. Rainbow trout, Salmo gairdneri Material: Three microslides
Diagnosis : Hepatoma
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2006. Fish, Chaenogobius annularis Material : One micro slide
Diagnosis: Infectious granuloma with epideimal hyperplasia Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2007. Goldfish, Carassius auratus Material: Two microslides
Diagnosis : Leiomyoma
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2008. Glue croaker, Nibea mitsukurii Material: Three microslides
Diagnosis: Melanoma
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2009. Fish, Lateolabrax j aponicus Material : Three micro si ides
Diagnosis: Lymphocystis
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2010. Rainbow trout, Salmo gairdneri Material: Five microslides
Diagnosis: Carcinoma (?) , sarcoma (?)
Submitter: Registry of Tumors in Poikilothermic Animals (Japan) RTLA 2011. Rainbow trout, Salmo gairdneri
-27-
RTLA 2011 (contd.)
Material: Two microslides
Diagnosis : Nephroblastoma
Submitter: Registry of Tumors in Poikilo thermic Animals (Japan)
RTLA 2012. Rainbow trout, Salmo gairdneri Material: Four microslides
Diagnosis: Hepatoma; adenomatous polyp of the stomach (M^G induced tumor)
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2013. Salmon, Qncorhynchus macro tomus Material : One microslide
Diagnosis: Cataracts
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2014. Walleye pollack, Theragra chalcogramma Material: One micro slide
Diagnosis : Fibroma
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2015. Rainbow trout, Salmo gairdneri Material: One microslide
Diagnosis : Nephroblastoma
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2016. Rainbow trout, Salmo gairdneri Material : One microslide
Diagnosis: Neurinoma
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2017. Salmon, Qncorhynchus macrotomus
Material : Diagnosis : Submitter : Reprint :
One microslide
Adenomatous polyp of the stomach
Registry of Tumors in Poikilothermic Animals (Japan) Kimura, I., T. Miyake, S. Kubota, A. Kamata,
S. Morikawa and Y. I to. Adenomatous Polyps in the Stomachs of Hatchery -Grown Salmonids and Other Types of Fishes. In: Progress in Experimental Tumor Research , Vol. 20 (F. Homburger, ed. ), Tumors in Aquatic Animals (C. J. Dawe, D. G. Scarpelli, and S. R. Wellings, eds.), pp. 181-194 (Larger, Basel 1976).
RTLA 2018-2021. Material : Diagnosis : Submitter :
Salmon, Qncorhynchus macrotomus One microslide each Hepatoma
Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2022. Salmon, Qncorhynchus macrotomus
-28-
RTLA 2022 (contd.)
Material: One microslide
Diagnosis : Adenomatous polyp of stomach
Submitter: Registry of Tumors in Poikilothermic Animals (Japan) Reprint: (See RTLA 2017)
RTLA 2023-2025. Material : Diagnosis : Submitter :
Yellowfin goby, Acanthogobius flavimanus One microslide each
Epidermal papillcana (amebic "x-cell" pseudotumor) Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2026. Rainbow trout, Salmo gairdneri Material: Three microslides
Diagnosis: Melanoma
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2027. Glue croaker, Nibea mitsukurii Material : One microslide
Diagnosis: Melanoma
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2028, 2029. Material : Diagnosis : Submitter :
Fish, Permatochromis kribensis One microslide each Suspicious meningioma
Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2030. Green swordtail, Xiphophorus helleri Material: One micros lide
Diagnosis : Suspicious retinoblastoma
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2031. Red goby, Chaeturichthys hexanema Material: Four microslides
Diagnosis: Papilloma (amebic "x-cell" pseudotumor)
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2032. Eel, Anguilla japonica Material: Two microslides
Diagnosis : Nephroblastoma
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2033. Chichibu goby, Tridentiger obscurus Material: One micros lide
Diagnosis: Papilloma (amebic "x-cell" pseudotumor)
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2034. Striped mullet, Mugil cephalus Material: Two microslides
Diagnosis: Parasitic cysts
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
-29-
RTLA 2035. Sharp toothed eel, Muraenesox cinereus Material: One microslide
Diagnosis: ’’Normal" testes
Submitter: Registry of Tumors in Poikilo thermic Animals (Japan)
RTLA 2036. Pacific cutlassfish, Trichiurus lep turns Material: One microslide
Diagnosis : Fibroma
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2037. Pacific cutlassfish, Trichiurus lepturus Material: One micro slide
Diagnosis: "Normal" testes
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2038. Chub mackerel. Scomber japonicus Material : One microslide
Diagnosis: Inflammatory fibrosis
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2039. Flounder, Limanda shrincki Material: Four microslides
Diagnosis: Papilloma (amebic "x-cell" pseudotumor)
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
RTLA 2040. Fish, Permatochromis kribensis Material : One microslide '
Diagnosis: Malignant melanoma
Submitter: Registry of Tumors in Poikilothermic Animals (Japan)
-30-
INDEX OF NEOPLASTIC AND HYPERPLASTIC LESIONS - ANIMAL GROUP - AND RTLA NUMBER
Adenocarcinoma: Bony fish - RTLA 1939; Amphibian - RTLA 1874, 1921
Adenomatous goiter versus follicular thyroid adenoma: Cartilaginous fish - RTLA 1851
Ameloblastoma: Bony fish - RTLA 2004 Angiosarcoma: Amphibian - RTLA 1959 Cataract: Bony fish - RTLA 1938, 2013 Erythrophoroma : Bony fish - RTLA 1875 Esthesioneuroepithelioma: Bony fish - RTLA 1931 Fibrolipoma: Bony fish - RTLA 1999
Fibroma: Bony fish - RTLA 1854, 1884, 2014, 2036; Reptile - RTLA 1856
Fibromyxosarcoma : Amphibian - RTLA 1873
Fibropapilloma: Reptile - RTLA 1856, 1883
Fibrosarcoma: Bony fish - RTLA 1848
Goiter: Bony fish - RTLA 1853, 1952
Gonadoblastoma: Bony fish - RTLA 1893
Hemangioendotheliosarcoma: Bony fish - RTLA 1862
Hemangioma: Bony fish - RTLA 1867
Hematopoietic neoplasm: Mollusk - RTLA 1940-1946; Bony fish - RTLA 1850, 1863, 1864, 1878; Amphibian - RTLA 1996; Reptile - RTLA 1960, 1879, 1880
Hepatocellular adenoma/carcinoma: Cartilaginous fish - RTLA 1851; Bony fish - RTLA 1868-1872, 2001, 2005, 2012, 2018-2021
Leiomyoma: Bony fish - RTLA 2007
Lipoma: Bony fish - RTLA 1922
Melanophoroma : Bony fish - RTLA 1847, 1951, 1988, 2003, 2008, 2027,
2040; Amphibian - RTLA 1886
-31-
Meningioma: Bony fish - RTLA 2028, 2029 Nephroblastoma: Bony fish - RTLA 1985, 2011, 2015, 2032 Neurilemmoma: Bony fish - RTLA 1889, 1891 Neurinoma: Bony fish - RTLA 2016 Neuroblastoma: Bony fish - RTLA 1930 Osteoma: Bony fish - RTLA 1983
Ovarian neoplasm: Arthropod - RTLA 1890; Bony fish - RTLA 2002
Papilloma: Bony fish - RTLA 1897, 1901, 1904, 1907, 2023-2025, 2031, 2033, 2039; Reptile RTLA 1917
Polycystic kidney: Bony fish - RTLA 1923, 1992
Retinoblastoma: Bony fish - RTLA 2030
Sarcoma: Mollusk - RTLA 1855; Bony fish - RTLA 2010
Spindle cell neoplasm: Bony fish - RTLA 1929
Transitional cell carcinoma: Reptile - RTLA 1937
Xanthoma: Reptile - RTLA 1955
-32-
PHYLOGENETIC INDEX
PHYLUM CHORDATA Class Reptilia
Order Chelonia (turtles) - RTLA 1856, 1879, 1880, 1883, 1885,
1927
Order Squamata (lizards, snakes, skinks) - RTLA 1849, 1912-1919, 1937, 1947-1950, 1954, 1955, 1960, 1991
Class Amphibia
Order Anura (toads, frogs) - RTLA 1857, 1874, 1881, 1887, 1911, 1921, 1925, 1926, 1996
Order Caudata (axolotls, salamanders, newts) - RTLA 1873, 1882, ■■■im','T9'0T,' 1959, 1987
Class Osteiohthyes
Order Gadiformes (codfishes, grenadiers) - RTLA 1868-1872, 1905, 1993, 2014
Order Ac ipenseri formes (sturgeons) - RTLA 1906, 1999
Order Tetraodontiformes (triggerfishes) - RTLA 1994
Order Anguilliformes (eels) - RTLA 2032, 2035
Order Clupeiformes (herrings, anchovies, menhaden) - RTLA 1848
Order Pleuronecti formes (flounders) - RTLA 2039
Order Gonorhynchi formes (milkfish) - RTLA 1876, 1877
Order Salmon! formes
Family Salmonidae (salmon, trout, whitefish, cisco) - RTLA 1862, 1867, 1884, 1888, 1899, 1908, 1936, 1938, 1961-1980, 1985, 1990, 2004, 2005, 2010-2013, 2015-2022, 2026
Family Esocidae (pikes) - RTLA 1909
Order Cypriniformes (suckers, goldfish, carp, minnows, roaches, scissorstail) - RTLA 1858-1861, 1875, 1878, 1889, 1892, 1893, 1901, 1907, 1910, 1923, 1929, 1931, 1939, 1956, 1992, 2002, 2007
-33-
Order Siluriformes (catfish, bullheads) - RTLA 1847, 1951
Order Atheriniformes (killifish, platys, needlefishes, guppies, mollies, top minnows) - RTLA 1850, 1865, 1920, 1924, 1930, 1935, 1952, 1957, 2001, 2030
Order Perciformes
Family Bramidae (pomfrets) - RTLA 1997
Family Trichiuridae (cutlassfishes) - RTLA 1854, 2036, 2037
Family Scorpaenidae (scorpionfishes) - RTLA 2000
Family Mugilidae (mullets) - RTLA 2034
Family Centrarchidae (sunfishes) - RTLA 1863, 1864
Family Scombridae (mackerels and tunas) - RTLA 1922, 2038
Family Pomadasyidae (grunts) - RTLA 1989
Family Serranidae (sea basses) - RTLA 1928, 1998, 2009
Family Gobiidae (gobies) - RTLA 1897, 2023-2025, 2031, 2033
Family Carangidae (jacks, pompanos) - RTLA 1894, 1895, 1900, 1983
Family Sparidae (porgies, pinfish) - RTLA 1891, 1896
Family Sciaenidae (drums, croakers) - RTLA 1904, 1986, 1988, 2003, 2008, 2027
Not classified - RTLA 1953, 1984, 2006, 2028, 2029, 2040 Class Chondriahthyes
Order Squaliformes (sharks) - RTLA 1852, 1866, 1898, 1958 Order Rajiformes (stingrays) - RTLA 1851, 1853
PHYLUM ARTHROPODA
Class Inseota (mayflies, cockroaches, true bugs, butterflies, moths, flies, beetles) - RTLA 1890, 1982
-34-
PHYLUM MOLLUSCA
Class Bivalvia (mussels, clams, scallops, oysters) - RTLA 1838-1846, 1855, 1902, 1932-1934, 1940-1946, 1995
Class Gastipopoda (snails) - RTLA 1981
-35-
INDEX OF SPECIMENS BY SCIENTIFIC AND COMMON NAMES
RTLA Number
A
|
Acanthogobius flavimanus |
1897, |
2023-2025 |
|
Acipenser transmontanus |
1999 |
|
|
African bullfrog |
1857 |
|
|
African sand snake |
1947 |
|
|
Amazon molly |
1924 |
|
|
Amby stoma sp. |
1903 |
|
|
Ambystoma mexicanum |
1882, |
1886 |
|
American oyster |
1838- |
1846 |
|
Anguilla japonica |
2032 |
|
|
Aplodinotus grunniens |
1891 |
|
|
Asian garden snake |
1918 |
|
|
Asian rat snake |
1919 |
|
|
Atlantic cod |
1905 |
|
|
Atlantic croaker |
1988 |
|
|
Atlantic tomcod B Ball snake |
1868- |
1872 |
|
1948 |
||
|
Barred pargo |
1953 |
|
|
Black cr apple |
1863, |
1864 |
|
Boa constrictor |
1950, |
1954, 1991 |
|
Brama japonica |
1997 |
|
|
Brevoortia gunteri |
1848 |
|
|
Brown bullhead |
1847, |
1951 |
|
Brown trout |
1884, |
1899 |
|
Bufo marinus |
1921 |
|
|
Burmese tortoise |
1879, |
1880 |
C
|
California needlefish |
1865 |
|
Callisaurus draconoides |
1849 |
|
Calotes calotes |
1918 |
|
Cantherhines scaber |
1994 |
|
Caranx sp. |
1983 |
|
Caranx hippos |
1894, 1895, 1900 |
|
Caras sius auratus |
1875, 1889, 1910, 1956, 1992, 2007 |
|
Caras sius auratus x Cyprinus carpio |
1893 |
|
Carcharodon carcharias |
1866 |
|
Carp |
1858-1860, 1892 |
|
Catostomus commersoni |
1861, 1907 |
|
Chaenogobius annularis |
2006 |
|
Chaeturichthys hexanema |
2031 |
|
Chanos chanos |
1876, 1877 |
1923,
1931,
-36-
RTLA Number
Cheilodactylus sp.
Che Ionia mydas
Chichibu goby
Chiysemys picta
Chub mackerel Coelorinchus australis
Colorado potato beetle
Coregonus artedii
Crassostrea gigas Crassostrea yirginica
Crevalle jack
Cynoscion regius C^rinodon variegatus Cyprinus carpio
1984
1856, 1883 2033
1885, 1927
2038
1993
1982
1990
1945
1838-1846
1894, 1895, 1900
1986
1935
1858-1860, 1892, 1901, 1939, 2002
1929,
D
Dasyatis akajei Drosophila melanogaster
E
Eastern brook trout Elaphe obsoleta Esox masquinongy European flat oys ter Euthynnus alletteratus
F
Finescale menhaden Flagfish Freshwater drum
1851, 1853 1890
1936
1937 1909
1855, 1940-1944, 1946 1922
1848
1952
1891
G
Gadus morhua Giant toad Glue croaker Goldfish
Goldfish/carp hybrid Goniistius sp.
Gopher snake Grammistes sexlineatus Granite spiny lizard
Green lizard Green swordtail Green turtle Guppy
1905
1921
2003, 2008, 2027 1875, 1889, 1910, 1923, 1931, 1956, 1992, 2007 1893 1984 1955 1928
1912, 1913
1917
2030
1856, 1883 1920, 1957
-37-
RTLA Number
H
Haemulon plumieri Hard clam
Holanthias martinicensis Hoplopagrus guntheri
Ictalurus nebulosus J
Jordanella floridae K
Koi carp L
Lacerta viridis Lagodon rhomboides Lake Herring Lake trout
Lamps ills anodontoides Lateolabrax j aponicus Leather j acket Lemon shark Leopard frog
Leptinotarsa decemlineata Leptodactvlus~pentadact>Tus
Limanda sririncki
Little tunny
M
Macrourid
Medaka
Mercenaria mercenaria Mexican axolotl Microgadus tomcod Micropogdn undulatus Milkfish Monitor lizard Morwong Mugil cephalus Muraenesox cinereus Mis kel lunge
1989
1934, 1995
1998
1953
1847, 1951
1952
1901, 1929, 1939, 2002
1917
1896
1990
1961-1980
1902
2009
1994
1898, 1958
1874, 1881, 1911, 1925, 1926
1982
1887
2039
1922
1993
1850, 2001 1934, 1995 1882, 1886 1868-1872 1988
1876, 1877 1916, 1949 1984
2034
2035 1909
-38-
RTLA Number
N
Matrix tessellata Megaprion brevirostris
Nibea miTsukurii Notophtbalmus viridescens
0
Olivella sp.
Oncorhynchus macrotomus Oncorhynchus masou
Oryzias latipes Ostrea edulis
P
Pacific cutlassfish Pacific ocean perch Pacific oyster Pacific pomfret Painted turtle Permatochromis kribensis Pinfish
Pitar morrhuana Pituophis melanoleucus Platyfish- swordtail' backcross hybrid Platypoecilus yariatus x
Xiphophorus helleri x
X. helleri BC^
Pleurodeles waltlii Poecilia formosa Poecilia reticulata Pomoxis nigromaculatus
Psammophis punctulatus Ptyas kofros Python regius Python reticulatus Pyxicephalus adspersus
R
Rainbow trout
Rana pipiens Red drum
Red goby Red- spotted newt Reticulate python Ribbed newt
1914
1898, 1958 2003, 2008, 2027 1987
1981
2013, 2017-2022 2004
1850, 2001
1855, 1940-1944, 1946
1854, 2036, 2037
2000
1945
1997
1885, 1927 2028, 2029, 2040 1896
1932, 1933 1955 1930 1930
1873, 1959 1924
1920, 1957 1863, 1864
1947 1919
1948 1960 1857
1862, 1888, 1908, 1938, 1985, 2005, 2010-2012, 2015, 2016, 2026
1874, 1881, 1911, 1925, 1926
1904
2031
1987
1960
1873, 1959
-39-
RTLA Number
Roach 1878 Russell's viper 1915 Rutilus rutilus 1878
S
Salmo clarki Salmo gairdneri
Salmo trutta Salvelinus fontinalis Salvelinus namaycusF" Scaphirh)^chus platorynchus
Sceloporus orcutti
Sciaenops ocellata
Scomber japonicus Sea bass
Sebastes alutus Sharptoothed eel Sheepshead minnow Shovelnose sturgeon Silver trevally Smokey jungle frog South African clawed frog Striped mullet Strongylura exilis
1867
1862, 1888, 1908, 1938, 1985, 2005, 2010-2012, 2015, 2016, 2026
1884, 1899 1936
1961-1980
1906
1912, 1913 1904 2038 1998 2000 2035 1935 1906 1983 1887 1996 2034 1865
T
Tessellated water snake Theragra chalcogramma
Triakis ~scyllia
Trichiurus lepturus Tridentiger ohscurus
V
1914
2014
1852
1854, 2036, 2037 2033
Varanus salvator Vipera russelli
1916, 1949 1915
W
Walleye pollack Weakfish White grunt White shark White sturgeon White sucker
2014
1986
1989
1866
1999
1861, 1907
-40-
RTLA Number
XYZ
|
Xenopus laevis |
1996 |
|
Xiphophorus helleri |
2030 |
|
Yellow rat snake |
1937 |
|
Yellow sand mussel |
1902 |
|
Yellowfin goby |
1897 |
|
Yellowstone cutthroat trout |
1867 |
|
Zebra-tailed lizard |
1849 |
-41-
CONTRIBUTORS
BUSACK, S. D.
Apartment #E 2231 Ward
Berkeley, California 94704 RTLA 1849
BAGSHAW, J.
Pacific Biological Station P. 0. Box 100 Nanaimo, British Columbia Canada V9R 5K6 RTLA 2000
BALAZS, G. H.
Hawaii Institute of Marine Biology University of Hawaii at Manoa P. 0. Box 1346, Coconut Island Kaneohe, Hawaii 96744 RTLA 1856, 1883
BALOUET, G.
Laboratoire d'Anatomie Pathologique
Centre Hospitaller Regional de Brest
B. P. 815
29279 Brest Cedex
France
RTLA 1940-1946 BLACK, J. J.
Roswell Park Memorial Institute 666 Elm Street Buffalo, New York 14263 RTLA 1891-1893
BLASIOLA, G. C. JR.
Ste inhart Aquarium
California Academy of Sciences
Golden Gate Park
San Francisco, California 94118
RTLA 1928
BOUSTEAD, N.
Fisheries Research Division Ministry of Agriculture and Fisheries P. 0. Box 19062 Wellington, New Zealand RTLA 1884, 1888, 1992-1994
BUCKE, D.
M.A.F.F. Fish Diseases Laboratory Weymouth, England RTLA 1878
BUSCH, R. A.
Rangen Research Station Rangen, Inc.
P. 0. Box 706 Buhl, Idaho 83316 RTLA 1908
CARNEY, J.
Eden Laboratories Medical Group , Inc .
20103 Lake Chabot Road
Castro Valley, California 94546
RTLA 1889, 1929
CORNICK, J. W.
Fish Health Unit Fisheries and Oceans Canada Box 550
Halifax, Nova Scotia Canada B3J 2S7 RTLA 1951
COSGROVE, G. E.
Zoological Society of San Diego Box 551
San Diego, California 92112 RTLA 1865
CRUTCHER, L.
Columbia National Fishery Research Laboratory Route 1
Columbia, Missouri 65201 RTLA 1938
DANIELS, B.
Insect Zoo, National Museum of Natural History Smithsonian Institution Washington, D. C. 20560 RTLA 1982
-42-
DASPIT, S.
Eden Laboratories Medical Group , Inc .
20103 Lake Chabot Road
Castro Valley, California 94546
RTLA 1939
DIAMOND, H.
Graduate School of Oceanography Narragansett Bay Campus University of Rhode Island Kingston, Rhode Island 02881 RTLA 1932-1934
DODGSHUN, T. J.
Fisheries Research Laboratory Ministry of Agriculture and Fisheries Private Bag
Christchurch, New Zealand RTLA 1923
DURYEE, W. R.
3241 North Woodrow Street Arlington, Virginia 22207 RTLA 1874, 1881
ECONOMON, P. P.
Division of Fish and Wildlife Ecological Services Section Minnesota Department of Natural Resources Centennial Office Building St. Paul, Minnesota 55155 RTLA 1899
ELISEEV, V. V.
Group of Comparative Oncology N. N. Petrov Research Institute of Oncology Leningrad, USSR 188646 RTLA 1886
ELKAN, E.
Department of Histopathology Mt. Vernon Hospital Northwood, Middlesex England HA6 2RN RTLA 1910-1919, 1947-1950
EMANUELSON, S.
1360 Cantelow Road Vacaville, California 95688 RTLA 1879, 1880
FLETCHER, K. C.
San ^Antonio Zoological Gardens and Aquarium
3903 North St. Mary's Street San iAntonio, Texas 78212 RTLA 1857
GORMAN, I.
Sharkey -Simpson
1500 West Santa Barbara Ave.
Los Angeles, California 900^2 RTLA 1954, 1991
GRIZEL, H.
Institut Scientifique et Technique des Pdehes Maritime 12 rue des Rdsistants La Trinitd sur Mer, France RTLA 1855
HARADA, T.
Faculty of Fisheries Hokkaido University Hakodate, Japan RTLA 1997
HELDSTAB, A.
Institut fUr Tierpathologie Universitat Bern Langgass-Strasse 122 3012 Bern, Switzerland RTLA 1960
HERRON, A. J.
The Animal Medical Center Department of Pathology 510 East 62nd Street New York, New York 10021 RTLA 1887, 1921
HIGFTTOIVER, J. A.
Department of Anatomy University of South Carolina School of Medicine Columbia, South Carolina 29208 RTLA 1987
-43-
HITACHI , PRINCE MASAHITO
Department of Experimental Pathology
Cancer Institute
Kami-Ikebukuro, Toshima-ku
Tokyo 170, Japan
RTLA 1850-1854, 1875
HNATH, J. G.
Wolf Lake Fish Hatchery Michigan Department of Natural Resources RR#1 Mattawan, Michigan 49071 RTLA 1858-1861, 1863, 1864, 1907, 1909, 1961-1980, 1990
ITO, Y.
Laboratory of Viral Oncology Aichi Cancer Center Research Institute Nagoya, Japan RTLA 1897
JMISCH, W.
Institute of Pathology
Martin-Luther-University
Leninallee 14
DDR - 402 Halle (Saale)
(German Democratic Republic)
RTLA 1873, 1959
JOHNSON, A. G.
Panama City Laboratory, SEFC National Marine Fisheries Service National Oceanic and Atmospheric Administration U. S. Department of Commerce Panama City, Florida 32407 RTLA 1848, 1904
KANDRASHOFF, W.
951 Euclid Avenue Miami Beach, Florida 33139 RTLA 1894-1896, 1900, 1922, 1958, 1988, 1989
KAUFMAN, H. W.
Division of Worms
National Museum of Natural History Smithsonian Institution Washington, D. C. 20560 RTLA 1981
KELLEY, N.
22 New End
London N . W . 3 , England RTLA 1956, 1957
KHUDOLEY, V. V.
Group of Comparative Oncology
N. N. Petrov Research Institute of Oncology
Leningrad, USSR 188646 RTLA 1886
KING, R. C.
Department of Biological Sciences
Northwestern University
O. T. Hogan Building Evanston, Illinois 60201 RTLA 1890
LANCE, V.
Biological Science Center Boston University 2 Cummington Street Boston, Massachusetts 02216 RTLA 1885, 1925-1927
LEFOLEY, T.
National Marine Water Quality Laboratory
U. S. Environmental Protection Agency
South Ferry Road
Narragansett , Rhode Island 02882 RTLA 1935
LIGHTNER, D. V.
Environmental Research Laboratory The University of Arizona Tucson International Airport Tucson, Arizona 85706 RTLA 1953
MCKINNEY, E. C.
Department of Microbiology University of Miami School of Medicine
P. 0. Box 875, Biscayne Mnex Miami, Florida 33152
RTLA 1898
-44-
NIUNDAY, B. L.
Mt. Pleasant Laboratories Department of Agriculture P. 0. Box 46
Launceston South, Tasmania 7250 RTLA 1983, 1984
MURCHELANO, R. A.
Oxford Laboratory National Marine Fisheries Service National Oceanic and Atmospheric Administration U. S. Department of Commerce Oxford, Maryland 21654 RTLA 1905
OISHI, K.
Faculty of Fisheries Hokkaido University Hakodate, Japan RTLA 1997
OTTO, S. V.
State Laboratory Maryland Department of Natural Resources Oxford, Maryland 21654 RTLA 1838-1846, 1995
PEAK, M. J.
Department of Zoology and Entomology Rhodes University P. 0. Box 94
Grahamstown, South Africa 6140 RTLA 1924
REGISTRY OF TUMORS IN
POIKILOTHERMIC ANIMALS (JAPAN) c/o Dr. Masao Ito Laboratory of Pathology Aichi Cancer Center Research Institute
Chikusa-ku, Nagoya, Japan RTLA 2001-2040
RIBELIN, W. E.
12673 Tallow Hill Lane Creve Coeur, Missouri 63141 RTLA 1847
RYAN, M. J.
Department of Pathobiology U-89
University of Connecticut Storrs, Connecticut 06268 RTLA 1955
SAUER, R. M.
Gillette Medical Evaluation Laboratories 1413 Research Boulevard Rockville, Maryland 20850 RTLA 1937
SCHMIDT, TH.
Anatomisches Institut der Mart in - Luther - Un iver s i t at Halle -Wittenberg German Democratic Republic RTLA 1873, 1959
SCHWAB, M.
Genetisches Institut der Justus -Liebig-Universitat Giessen
Heinrich-Buff-Ring 58-62, FRG D-6300 Giessen, West Germany RTLA 1930
SCHWARTZ, F. J.
Institute of Marine Sciences University of North Carolina P. 0. Drawer 809 Morehead City, N. C. 28557 RTLA 1986
SEYFERT, F. C.
Grice Marine Biological Laboratory
College of Charleston 205 Fort Johnson
Charleston, South Carolina 29412 RTLA 1998
SHERMAN, S. J.
23840 Jerome
Oak Park, Michigan 48237 RTLA 1920
-45-
SMITH, A. C.
Oceanic Institute Makapuu Point Waimanalo, Hawaii 96795 RTLA 1876, 1877
SMITH, C. E.
Fish Cultural Development Center U. S. Department of the Interior 4050 Bridger Canyon Road Bozeman, Montana 59715 RTLA 1862, 1867-1872, 1906, 1985
SNARSKI, V. M.
Environmental Research Laboratory U. S. Environmental Protection Agency
6201 Congdon Boulevard Duluth, Minnesota 55804 RTLA 1952
STOCKLEY, C. E.
Columbia River Fisheries Laboratory
Washington Department of Fisheries 2300 East Second Street Vancouver, Washington 98661 RTLA 1999
VERHOEFF-DE FREMERY, R.
Animal Department
Hubrecht Laboratory
Universiteitscentrum ,,de Uithof"
Uppsalalaan 8
Utrecht, The Netherlands
RTLA 1882, 1903, 1996
VIRKAR, R. A.
Department of Biology Kean College of New Jersey Union, New Jersey 07083 RTLA 1902
WARNER, R. W.
Marine Resources Laboratory California Department of Fish and Game
619 Second Street, Room 111 Eureka, California 95501 RTLA 1866
WOLF, H.
Fish Disease Laboratory California Department of Fish and Game
2111 Nimbus Road
Rancho Cordova, California 95670 RTLA 1901, 1931, 1936
TEAR OUT ACCESSION SHEET
PLEASE SUBMIT TO:
Dr. John C. Harshbarger Registry of Tumors in Lower Animals National Museum of Natural History Room W216“A
Smithsonian Institution Washington, D.C., 20560, USA
COMMON NAME FAMILY _ _
PHYLUM GENUS
CLASS SPECIES _ _ _ _ _
order ____________________
CATEGORY: NEOPLASM _ _ INFLAMMATION __ INFECTION ___ PARASITIC __ TOXIC
DEVELOPMENTAL ___ TRAUMATIC _ _ NORMAL __ OTHER ___
CONTRIBUTOR (NAME & ADDRESS): COLLECTOR (NAME & ADDRESS):
DATE RECD. _ _
CONTRIBUTOR'S NOo RTLA NO, _____ USNM NO, _____ NIH HISTOPATH NO.
ITEMS SUBMITTED (QUANTITY): GROSS MATERIAL ______
SLIDES ___________
BLOCKS _ _
ORIGIN OF ANIMAL: MARINE _ WHERE COLLECTED
_ PHOTOGRAPHS _ _ _
_ _ REPRINTS _ _ _
_ _ OTHER _ _ _ _ _
FRESHWATER _ _ ESTAURINE _ TERRESTRIAL
date collected _______ SEX _ AGE ________ STAGE OF LIFE CYCLE
HOW KILLED _ _ _ _ _ FIXATION _ _
GROSS DESCRIPTION _ _ _ _ _ _ _
MICROSCOPE DX
COMlffiNTS (e.g,, possible exposure to chemical pollutants or infectious agents, in¬ cidence and duration of this condition in the population, etc.)
(Please use reverse side, if more space is needed)
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^^iilViT-IES , REPORT
r;egistry.:oE‘
.979:; surpEemen^
iN;'i,bw,ER-
'jto" c . - hab^arger; rbipctoR’
PREPARED. FOR EISTRIBUTTON BY
REGISTRY OF TUMORS' - IN LOWER '^MALS NATIONAL MUSEUM OF NATUR^ 'HISTORY ROOM- W216-A.,, ' '^v.
SMITHSONIAN INSTiTUTlOM: : , WASHINGTON, b. C. 20560
“SB 8 7 A ( Ar ' Smi t HsAti iaq.' ' Tn s 1 1 tu 1 1 on )
vSi'--- • ' ■" ■ ■ 4 '■ ■ .I.- - 1 . • I ■■; '.’.i, :/; ■ • . ■ ' . '
CONTENTS
OVERVIEW . 1
REFERENCE LIBRARY . 4
PAPERS SINCE 1978 . 4
SELECTED ACTIVITIES IN 1979 . . . 5
PERSONNEL . 7
ACCESSIONS . . . 1 8
INDEX OF NEOPLASTIC AND HYPERPLASITC LESIONS -
ANIMAL GROUP - AND RTLA NUMBER . 29
PHYLOGENETIC INDEX . 31
INDEX OF SPECIMENS BY SCIENTIFIC AND
COMMON NAMES . 34
CONTRIBUTORS . 40
TEAR OUT ACCESSION SHEET . Last page
Smithsonian Institution Washington, D. C. 1980
OVERVIEW
The Registry of Tumors in Lower Animals (RTLA) facilitates the study of neoplasms and related disorders in invertebrate and poikilothermlc vertebrate animals by serving as a specimen deposi¬ tory, a diagnostic center, an information center, and a research group.
One hundred seventy-nine accessions (many with multiple specimens) from 13 countries were entered into the Registry’s permanent collection in 1979. As shown in Table 1, nearly one- half were neoplasms which occurred, in decreasing numbers, in bony fish, mollusks, reptiles, amphibians, sharks and one platyhelminth.
TABLE 1
Distribution of lesions among specimens accessioned
|
Phylogenetic group |
Type of disease |
|||
|
Neoplastic |
Non-neoplastic |
Total |
||
|
Reptile |
8 |
6 |
14 |
(8%) |
|
Amphibian |
7 |
8 |
15 |
(8%) |
|
Bony fish |
51 |
51 |
102 |
(57%) |
|
Shark |
2 |
1 |
3 |
(2%) |
|
Mollusk |
17 |
19 |
36 |
(20%) |
|
Arthropod |
0 |
3 |
3 |
(2%) |
|
Annelid |
0 |
3 |
3 |
(2%) |
|
Platyhelminth |
1 |
1 |
2 |
(1%) |
|
Coelenterate |
0 |
1 |
1 |
(1%) |
|
Total |
86 (48%) |
93 (52%) |
179 |
(100%) |
New contributions introduced neoplasia into a third invertebrate phylum, added or reinforced taxonomic, cell of origin and geograph¬ ic records and included new information on etiology.
A dome-shaped protrusion in a parasitic fluke (RTLA 2077) from D. I. Gibson is the strongest candidate neoplasm yet seen in Platy-
-2-
helminthes, a phylum at the primitive level of only two germ layers. The lesion was composed of pleomorphic, basophilic non¬ polarized ganglioneuroblast-like cells presenting mitotic figures of widely ranging size.
Neural neoplasms were also well represented in fish accessions. CNS tumors included an astrocytoma in a pollock (RTLA 2047; D. Bucke) , an esthesioneuroepithelioma in a goldfish (RTLA 2051; H. Wolf) and an epend3nnoblastoma in a coho salmon (RTLA 2116; Prince Mssahito) . PNS tumors include neurilemmoma in rainbow trout (RTLA 2049; K. Wolf), goldfish also having polycystic kidney (RTLA 2053; S. Pullan) , coho salmon (RTLA 2074; R. Moccia) , Malabar anchovy (RTLA 2142; S. Radhakrishnan) , lingcod (RTLA 2174; R. Warner), and brown trout (RTLA 2217; N. Boustead) ; and neurofibroma/neurofibrosarcoma in striped mullet (RTLA 2095; N. Boustead), pink salmon (RTLA 2156; G. Bell), Dover sole and black cod (RTLA 2169 and RTLA 2180; R. Warner).
An additional neural tumor, rare in mammals and never pre¬ viously seen in poikilotherms, was a granular cell myoblastoma in¬ duced in a South African clawed frog with methylnitrosourea (RTLA 2219; W. Janlsch and Th. Schmidt). This compound also produced <
nephroblastoma in a ribbed newt (RTLA 2182; W. JSnisch) .
Other induced neoplasms included hepatocellular carcinoma, renal adenocarcinoma and cyst adenoma in South African clawed frogs exposed to N-nitrosodimethylamine (RTLA 2123-RTLA 2126; V. V.
Khudoley) ; hepatocellular carcinoma in top minnows exposed to dimethylbenzanthracene and diethylnltrosamine (RTLA 2145, RTLA 2146; R. J. Schultz) ; and hepatocellular carcinoma in Amazon mollies treated with aflatoxin (RTLA 2149, RTLA 2150; A. Woodhead) .
Thyroid enlargement and ectopic thyroid in spleen occurred in Amazon mollies treated with anthracene (RTLA 2151-RTLA 2153; A. Woodhead) . Thyroid enlargements also occurred in various untreated accessions including sheepshead minnow and darter goby (RTLA 2058 and RTLA 2071; J. Couch), lemon shark (RTLA 2061; S. H. Gruber), rabbitfish and sandbar shark (RTLA 2106 and RTLA 2110; Prince Masahito) , spiny dogfish (RTLA 2165; A. Woodhead), roach (RTLA 2188;
W. Slooff) and coho salmon RTLA 2211, RTLA 2212; C. E. Smith).
These cases have all been Interpreted very conservatively — mostly as hyperplasia — because fish seem to be especially susceptible to a wide variety of goitrogens. Additionally, thyroid is unencapsu¬ lated in bony fish, is capable of destructive infiltration into normal tissue when hyperplasitc, and can occur ectopically in kid¬ ney, spleen and other sites. The question of neoplastic versus hy¬ perplastic fish thyroid has been inconclusively debated most of the 20th century and until resolved it seems prudent to interpret ques¬ tionable cases as hyperplastic.
Pigment cell neoplasms of three types of chromatophores in reptiles and fish included erythrophoroma and melanophoroma in
-3-
goldfish (RTLA 2052 and B.TLA 2141; R. Pickering, ^ and S. Radhakri shnan) and Dover sole (RTLA 2168; R. Warner). They also included an amelanotic melanophoroma (some considered it a giant cell epulis) in a boa constrictor (RTLA 2070; A. Heldstab) and an iridophoroma with beautiful reflecting platelets in a pine snake (RTLA 2130; E. Jacobson).
Spontaneous hepatocarcinoma in a cicblid fish (RTLA 2111;
Prince Masahito) and a bream (RTLA 2155; W. Slooff) and nephro¬ blastoma in two rainbow trout (RTLA 2154 and RTLA 2210; C. E.
Smith) were all isolated cases. There were no new epizootics to indicate the possibility of environmental chemical carcinogens.
Connective tissue neoplasms included lipoma/f ibrolipoma in Chinook salmon (RTIA 2098; K. Neiland) , red-tail catfish (RTLA 2112; Prince Masahito), Dover sole and lingcod (RTLA 2170-RTLA 2173; R. Warner) and rockfish (RTLA 2177, RTLA 2178; R. Warner); fibroma/fibrosarcoma in an eel (RTLA 2055; R. Mason), a rainbow trout (RTLA 2062; N. Boustead), a basilisk (RTLA 2069; A. Heldstab), a black bullhead (RTLA 2078; J. Goudzwaard) , a denticle herring and Malayan monitor (RTLA 2113, RTLA 2114: Prince Masahito), and a black cod and an English sole (RTLA 2179 and RTLA 2181; R. Warner); and myxoma and myxofibroma in an iguana (RTLA 2073; F. L. Frye) and a shortspine thornyhead (RTLA 2175; R. Warner).
A mesothelioma occurred in a coho salmon (RTLA 2043; A. Hauck) and a gill hamartoma in a brown trout (RTLA 2213; R. Moccia) .
Epidermal tumors included f ibropapilloma in a green sea turtle (RTLA 2097; G. Balazs) , squamous polyp in a goby (RTLA 2107; Prince Masahito) and epidermal papilloma in spotted gar (RTLA 2115; Prince Masahito), three-spot gourami (RTLA 2143; S. Radhakr i shnan ) , pink salmon (RTLA 2215; T. Awakura) , and rock oyster (ETLA 2157, RTLA 2183-RTLA 2187; P. Wolf).
Germinoma were seen both in hard clams (RTLA 2085-RTLA 2090,
RTLA 2137-RTLA 2139; H. Diamond) and soft clams (RTLA 2091; J. Harshbarger, ^ aJ^. ) . Electron microscopy of nuclear inclusions in hard clams were negative for viral particles.
Hematopoietic neoplasms included a thymic lymphoma in a rainbow trout (RTLA 2129; C. E. Smith), a plasmacytoma in a channel catfish (RTLA 2166; J. Grizzle) which is possibly the first neoplasm seen in this catfish and a hyaline hemocyte neoplasm in an American oyster (RTLA 2132; J. Couch). While no hematopoietic neoplasms were con¬ tributed in soft clams, it is of interest that P. Chang has, in collaboration, followed up on successful transmission studies done by R. Brown and isolated a retrovirus which transmits the disease.
I understand that a paper is in press in the "Journal of Invertebrate Pathology" .
Among miscellaneous neoplasms were a shortspine thornyhead compound odontoma (RTLA 2176; R. Warner), a blue acara (RTLA 2140;
-4-
S. Radhakrishnan) and cottonmouth (RTLA 2208; J. E. Cooper) hemangio¬ endothelioma and a possible mucoadenocarcinoma in a boa constrictor (RTLA 2133; I. Gorman).
Accessions with interesting though non-neoplastic lesions in¬ cluded a series of bivalve mollusks in a disease survey (RTLA 2194- RTL^. 2207; W. A. Heath), a planarian with globular growths similar to earlier cases containing virus-like inclusions (RTLA 2041; C. Lange), Ohio River emerald shiner with cubic nuclear inclusions in dorsal root ganglion cells shown by K. Hoover, to be protein (RTLA
2056) , leeches with several lesions including a cuticular hyperplasia (RTLA 2044-RTLA 2046; J. Kuf el) , a cardiac muscle anomaly in an American oyster (RTLA 2079; S. V. Otto), coho salmon lens hyper¬ plasia (RTLA 2117-RTLA 2122; G. Balouet and F. B. Laurencin), dolphin (fish) with fractured centrum of two vertebrae and associated exu¬ berant callus formation (RTLA 2167; W. Kandrashof f ) , fracture of femur followed by dystrophic callus formation of leopard frog (RTLA 2191- RTLA 2193; A. Klempau) , reactive hyperplasia and tooth formation in an angelfish (RTLA 2189; G. Blasiola, Jr.), prokaryotes (rickettsia, some with phage, and chlamydia) in soft clams (RTLA 2091; J. ,
Harshbarger, £t ^.), a blue mussel (RTLA 2083; R. Higgins), hard clams (RTLA 2088 and RTIA 2090; H. Diamond) and other parasites and anomalies.
REFERENCE LIBRARY
The comprehensive library on neoplasms in lower animals in¬ creased to 3,830 papers. Except for recent acquisitions and articles that need to be translated, all papers have been abstracted by select¬ ed key words and computerized.
PAPERS SINCE 1978
Harshbarger, J. C., S. V. Otto, and S. C. Chang. 1977. (1979). Pro¬ liferative disorders in Crassostrea virginica and Mya arenaria from, the Chesapeake Bay and intra-nuclear virus-like incl"sions in Mya arenaria with germinomas from a Maine oil spill site. Haliotis, 243-248.
Otto, S. V., J. C. Harshbarger, and S. C. Chang. 1977. (1979). Status of selected unicellular eucaryote pathogens, and prevalence and histopathology of inclusions containing obli^^ate procaryote para¬ sites, in commercial bivalve mollusks from Maryland estuaries. Haliotis, 8: 285-295.
DeLanney, L. , S. C. Chang, J. Harshbarger, and C. J. Dawe. 1980.
Mast cell tumors in the caudate amphibian, Amby stoma mexicanum.
In: Advances in comparative leukemia research, D. Yohn, B. Lapin and J. Blakeslee, ed. , pp. 221-222, Elsevier: New York.
-5-
Harshbarger, J. C., E. R. Jacobson, C. E. Smith, and J. A. Couch.
1980. Hematopoietic neoplasms in invertebrates and cold-blooded vertebrates. In: Advances in comparative leukemia research, D.
Yohn, B. Lapin and J. Blakeslee, ed. , pp. 223-225, Elsevier:
New York.
Sindermann, C. J. , F. E. Bang, N. 0. Christensen, V. Dethlefsen,
J. C. Harshbarger, J. R. Mitchell, and M. F. Mulcahy. 1980.
The role and value of pathobiology in pollution effects monitor¬ ing programs. Rapp. P.-v. Rdun. Cons. int. Explor. Mer, 179 : 135- 151.
Harshbarger, J. C. (in press). Neoplasms in zoo poikilotherms em¬ phasizing cases in the Registry of Tumors in Lower Animals. Pro¬ ceedings of the Symposium on the Comparative Pathology of Zoo Ani¬ mals, October 2-4, 1978, Washington, D. C.
Chang, S. C., J. C. Harshbarger, and S. V. Otto, (in press). Status of cytoplasmic prokaryote infections and neoplasms in bivalve mol- lusks. Proceedings of the Sixth Food and Drug Administration Sci¬ ence Symposium on Aquaculture: Public Health, Regulatory, and Manage¬ ment Aspects, February 12-14, 1980, New Orleans, Louisiana.
SELECTED ACTIVITIES IN 1979
A. Research activities :
1. Studied, diagnosed and described for the files approximately 180 cases of diseases in cold-blooded vertebrates and inverte¬ brates.
2. Collaborated with Karen L. Hoover (National Cancer Institute) and Sing C. Chang on the study of cubic nuclear protein inclu¬ sions in ganglion cells of emerald shiner from the Ohio River.
3. Collaborated with Sara V. Otto (Maryland Department of Natural Resources, Oxford, Md.) and Sing C. Chang on the incidence, distribution, cellular structure and fine structure of chlamy¬ dia, rickettsia and mycoplasma parasites in bivalve mollusks.
4. Collaboratored with Peter H. Wolf (New South Wales State Fisheries, Sydney, Australia) and Sing C. Chang on the fine structure of papillary epitheliomas of the mantle in the Sydney rock oyster, Crassostrea commercialis .
5. Collaborated with Clyde J. Dawe (National Cancer Institute, Bethesda, Md.), Louis E. Delanney (Bar Harbor, Me.) and Sing C. Chang on the fine structure of mastocytomas in the axolotl, Ambystoma mexicanum.
-4-
S. Radhakrishnan) and cottonmouth (RTLA 2208; J. E. Cooper) hemangio¬ endothelioma and a possible mucoadenocarcinoma in a bca constrictor (RTLA 2133; I. Gorman).
Accessions with interesting though non-neoplastic lesions in¬ cluded a series of bivalve mollusks in a disease survey (RTLA 2194- RTLA 2207; W. A. Heath), a planarian with globular growths similar to earlier cases containing virus-like inclusions (RTLA 2041; C. Lange), Ohio River emerald shiner with cubic nuclear Inclusions in dorsal root ganglion cells shown by K. Hoover, £t to be protein (RTIA 2056) , leeches with several lesions including a cuticular hyperplasia (RTLA 2044-RTLA 2046; J. Kufel) , a cardiac muscle anomaly in an American oyster (RTLA 2079; S. V. Otto), coho salmon lens hyper¬ plasia (RTLA 2117-RTLA 2122; G. Balouet and F. B. Laurencin), dolphin (fish) with fractured centrum of two vertebrae and associated exu¬ berant callus formation (RTLA 2167; W. Kandrashof f ) , fracture of femur followed by dystrophic callus formation of leopard frog (RTLA 2191- RTLA 2193; A. Klempau) , reactive hyperplasia and tooth formation in an angelfish (RTLA 2189; G. Blasiola, Jr.), prokaryotes (rickettsia, some with phage, and chlamydia) in soft clams (RTLA 2091; J. Harshbarger, ^^.), a blue mussel (RTLA 2083; R. Higgins), hard clams (RTLA 2088 and RTIA 2090; H. Diamond) and other parasites and anomalies.
REFERENCE LIBRARY
The comprehensive library on neoplasms in lower animals in¬ creased to 3,830 papers. Except for recent acquisitions and articles that need to be translated, all papers have been abstracted by select¬ ed key words and computerized.
PAPERS SINCE 1978
Harshbarger, J. C., S. V. Otto, and S. C. Chang. 1977. (1979). Pro¬ liferative disorders in Crassostrea virginica and Mya arenaria from, the Chesapeake Bay and intra-nuclear vlrus-llke incl”sions in Mya arenaria with germinomas from a Maine oil spill site. Hallotis, 8: 243-248.
Otto, S. V., J. C. Harshbarger, and S. C. Chang. 1977. (1979). Status of selected unicellular eucaryote pathogens, and prevalence and histopathology of inclusions containing obligate procaryote para¬ sites, in commercial bivalve mollusks from Maryland estuaries. Haliotis, 8: 285-295.
DeLanney, L. , S. C. Chang, J. Harshbarger, and C. J. Dawe. 1980.
Mast cell tumors in the caudate amphibian, Amby stoma mexicanum.
In: Advances in comparative leukemia research, D. Yohn, B. Lapin and J. Blakeslee, ed. , pp. 221-222, Elsevier: New York.
-5-
Harshbarger, J. C., E. R. Jacobson, C. E. Smith, and J. A. Couch.
1980. Hematopoietic neoplasms in invertebrates and cold-blooded vertebrates. In: Advances in comparative leukemia research, D.
Yohn, B. Lapin and J. Blakeslee, ed. , pp. 223-225, Elsevier:
New York.
Sindermann, C. J., F. E. Bang, N. 0. Christensen, V. Dethlefsen,
J. C. Harshbarger, J. R. Mitchell, and M. F. Mulcahy. 1980.
The role and value of pathobiology in pollution effects monitor¬ ing programs. Rapp. P.-v. Rdun. Cons. int. Explor. Mer, 179 : 135- 151.
Harshbarger, J. C. (in press). Neoplasms in zoo poikilotherms em¬ phasizing cases in the Registry of Tumors in Lower Animals. Pro¬ ceedings of the Symposium on the Comparative Pathology of Zoo Ani¬ mals, October 2-4, 1978, Washington, D. C.
Chang, S. C., J. C. Harshbarger, and S. V. Otto, (in press). Status of cytoplasmic prokaryote infections and neoplasms in bivalve mol- lusks. Proceedings of the Sixth Food and Drug Administration Sci¬ ence Symposium on Aquaculture: Public Health, Regulatory, and Manage¬ ment Aspects, February 12-14, 1980, New Orleans, Louisiana.
SELECTED ACTIVITIES IN 1979
A. Research activities :
1. Studied, diagnosed and described for the files approximately 180 cases of diseases in cold-blooded vertebrates and inverte¬ brates.
2. Collaborated with Karen L. Hoover (National Cancer Institute) and Sing C. Chang on the study of cubic nuclear protein inclu¬ sions in ganglion cells of emerald shiner from the Ohio River.
3. Collaborated with Sara V. Otto (Maryland Department of Natural Resources, Oxford, Md.) and Sing C. Chang on the incidence, distribution, cellular structure and fine structure of chlamy¬ dia, rickettsia and mycoplasma parasites in bivalve mollusks.
4. Collaboratored with Peter H. Wolf (New South Wales State Fisheries, Sydney, Australia) and Sing C. Chang on the fine structure of papillary epitheliomas of the mantle in the Sydney rock oyster, Crassostrea commercialls .
5. Collaborated with Clyde J. Dawe (National Cancer Institute, Bethesda, Md.), Louis E. Delanney (Bar Harbor, Me.) and Sing C. Chang on the fine structure of mastocytomas in the axolotl, Ambystoma mexicanum.
-6-
6. Collaborated with John Hurst and Robert Dow (Maine Department of Marine Resources, West Boothbay Harbor, Me.) and Sing C. Chang on a study to determine if germinomas in the soft clam, Mya arenaria, from an oil spill site were caused by hydrocar¬ bons in the environment and to determine if nuclear inclusions in tumor cells are virus.
B. Other activities :
1. Member of the World Committee International Association for Comparative Research on Leukemia and Related Diseases.
2. Member of the Interagency Collaborative Group on Environmental Carcinogenesis .
3. Member of the Permanent Program Committee of the Society for Invertebrate Pathology.
4. Member of the Editorial Board of the "Journal of Fish Diseases".
5. President of the Washington, D. C. Chapter of Sigma Xi. ^
6. Attended the Foundation for Advanced Education in the Sciences course, "Essentials of Toxicology," National Institutes of Health, Bethesda, Md. , Spring 1979.
C. Meetings ;
1. Participated in the International Council for the Exploration of the Sea (ICES) Workshop on Problems of Monitoring Biologi¬ cal Effects of Pollution in the Sea, February 26-March 2, 1979, Duke University Marine Laboratory, Beaufort, North Carolina.
2. Presented "Overview of neoplastic diseases and cytoplasmic procaryote diseases in fish and shellfish," Fourth Annual Fish Health Workshop, June 25-27, 1979, Halifax, Nova Scotia.
3. Presented "Neoplastic diseases of fish: significance to cancer research," 116th Annual Meeting of the American Veterinary Medical Association, July 23-26, 1979, Seattle, Washington.
4. Attended the Xllth Annual Meeting of the Society for Inverte¬ brate Pathology, August 26-30, 1979, Gainesville, Florida.
5. Presented "Hematopoietic neoplasms in Invertebrates and cold¬ blooded vertebrates," IXth International Symposium on Compara¬ tive Research on Leukemia and Related Diseases, October 2-6, 1979, Pitsunda, Russia.
6. Attended Pollutant Responses in Marine Animals (PRIMA) Advisory Meeting, October 21-23, 1979, Texas A & M University, College Station, Texas.
-7-
7. Participated in the Annual Review of the National Cancer
Institute funded/U. S. Environmental Protection Agency (EPA) administered program on aquatic environmental carcinogenesis, EPA Laboratory, November 11 and 12, 1979, Gulf Breeze, Florida
|
PERSONNEL |
|
|
Co-Project Officer: |
Dr. Clyde J. Dawe, Head, Comparative Oncology Section, Laboratory of Pathology, National Can¬ cer Institute, National Institutes of Health, Bethesda, Maryland, 20205 |
|
Co-Project Officer: |
Dr. Brian W. Kimes, Division of Cancer Re¬ search Resources and Centers, National Can¬ cer Institute, National Institutes of Health, Bethesda, Maryland, 20205 |
|
Principal Investigator: |
Dr. W. Duane Hope, Chairman, Department of Invertebrate Zoology, National Museum of Natural History, Smithsonian Institution, Washington, D. C., 20560 |
Registry Staff
|
Director: |
John C. Harshbarger, Ph.D. |
|
Microbiologist/ |
Electron Microscopist ; Sing Chen Chang, Ph.D
|
Registrar: |
Phyllis M. Spero (Schellenger) , B. S. |
|
Histopathology Technologist : |
Linda J. Cullen, B. A. |
|
Research Assistant : |
Ann M. Charles, B. A. |
Research Assistant :
Marilyn S. Slatick, B. S.
-8-
ACCESSIONS
RTLA 2041. Planarian, Dugesla etrusca
|
Material: |
Eight live animals (plus 4 dead on arrival) with glob¬ ular protrusions |
|
Habitat : Diagnosis : Submitter : |
Laboratory stock Pending electron microscope study C . Lange |
RTLA 2042. Hawksbill turtle, Eretmochelys Imbricata
|
Material: Habitat : |
Tissue mass associated with mesentery Sea turtle pond at Sea Life Park, Inc., Makapuu, Hawaii |
|
Diagnosis : Submitter : |
"Normal" fat body G. H. Balazs |
RTLA 2043. Coho salmon, Oncorhynchus klsutch
|
Material : Habitat : Diagnosis : Submitter: |
Wedge of tissue from growth in visceral cavity Near Noyes Island, Alaska (Southeastern Alaska) Mesothelioma — fibrous type A. K. Hauck |
RTLA 2044. Leech, Hemiclepsis marginata
|
Material : Habitat : |
One microslide of a ventral growth Latteral bed of Barycz near to Milicz, Lower Silesia, Poland |
|
Diagnosis : Submitter : |
Possibly a developmental anomaly J. Kufel |
RTLA 2045. Leech, Erpobdella octoculata
|
Material: |
One microslide of 2 cuticular lesions; 1 black and |
|
Habitat : Diagnosis : Submitter: |
white photograph Jaskowice Lake near Legnica, Lower Silesia, Poland Hyperplasia, cuticular epithelium J. Kufel |
RTLA 2046. Leech, Hemiclepsis marginata
|
Material: Habitat : |
One microslide; 1 black and white photograph Latteral bed of Barycz near to Milicz, Lower Silesia, Poland |
|
Diagnosis : |
Parasitic fistula between the alimentary canal and the body wall resulting from penetration by helminths |
|
Submitter : |
J. Kufel |
RTLA 2047. Pollock (coalfish), Pollachlus virens
|
Material: |
Two microslides; 1 color transparency; map of collect¬ ing site |
|
Habitat : Diagnosis : |
North Sea off the Shetland Islands Well-differentiated, olfactory astrocytoma containing an ependymal cell component |
|
Submitter: |
D. Bucke |
-9-
RTLA 2048. Whiting, Gadus merlangus
Material: Two microslides; 1 color transparency; map of collect¬
ing site
Habitat: North Sea off the Shetland Islands
Diagnosis: Traumatic hemorrhage and fibrosis — possibly due to a hook Injury Submitter: D. Bucke
RTLA 2049. Rainbow trout, Salmo gairdneri
Material: Growth from the visceral cavity
Diagnosis: Neurilemmoma with distinctive Antonio Type A pattern Submitter: K. E. Wolf
RTLA 2050. Goldfish, Carassius auratus
Material: Kidney tissue; 4 microslides
Diagnosis: Parasitism by Mitraspora cyprini Submitter: G. E. Smith and G. L. Hoffman
RTLA 2051. Goldfish, Garassius auratus Material: Five paraffin blocks
Habitat: Big Bear Lake, San Bernadino County, California
Diagnosis: Olfactory neuroepithelioma or esthesioneuroepithelioma Submitter: H. Wolf
RTLA 2052. Koi carp, Cyprlnus carpio Material: One microslide
Habitat: California Koi Farms, Inc., Fallbrook, California
Diagnosis: Erythrophoroma
Submitter: R. Pickering, T. Adachi, and R. A. Murchelano
RTLA 2053. Goldfish, Carassius auratus
Material:
Habitat : Diagnosis: Submitter :
A piece of body wall with a ruptured cyst-like growth attached to the peritoneum; a cyst-like growth; a bilobed external growth from the left body wall Backyard pond in New Zealand Polycystic kidney and neurilemmoma S. G. Pullan
RTLA
2054. Corn Material: Habitat :
Diagnosis: Submitter :
snake, Elaphe guttata guttata
Growth removed from the side of the snake
Pet shop, Los Angeles, California (Florida import,
June 1978)
Fungal granuloma I . Gorman
RTLA 2055. Eel Material: Habitat : Diagnosis: Submitter:
One microslide
Stream in northeastern Tasmania Dermal ossifying fibrosarcoma R. W. Mason
-10-
RTLA 2056. Emerald shiner, Notropis atherlnoides Material: Sixty- three whole fish
Habitat: Ohio River (Dashields lock and dam), near Sewickley,
Pennsylvania
Diagnosis: Idiopathic, proteinacous , cubic nuclear inclusions
in dorsal root ganglion cells Submitter: K. L. Hoover
RTLA 2057. Goldfish, Carassius auratus
Material: Whole animal with cystic kidney
Diagnosis: Parasitism by Mltraspora cyprini Submitter: G. L. Hoffman
RTLA 2058. Sheepshead minnow, Cyprlnodon variegatus Material: Two microslides
Diagnosis: Thyroid hyperplasia
Submitter: J. A. Couch
RTLA 2059. Rainbow trout, Salmo gairdneri Material: One microslide
Diagnosis: Acute necrotizing gastroenteritis followed by a fatal peritonitis Submitter: B. L. Munday
RTLA 2060. Tiger salamander, Amby stoma tigrinum
Material: Testis with an adjacent cyst-like lesion
Habitat: Reese Air Force Base, Hurlwood, Texas
Diagnosis: Old resolving hematoma Submitter: F. L. Rose
RTLA 2061. Lemon shark, Negaprion brevlrostris
Material: Habitat :
Diagnosis : Submitter :
Head
Collected off Lower Matecumbe Key, Florida; kept in captivity for years at the University of Miami, Miami, Florida Goiter
S. H. Gruber
RTLA 2062. Rainbow trout, Salmo gairdneri
Material: Portions of kidney, liver, and spleen and a piece
of dorsal body wall with one-half of a cauliflower¬ like cutaneous growth
Habitat: Tongariro River, North Island, New Zealand
Diagnosis: Cutaneous fibroma Submitter: N. Boustead
RTLA 2063. Walleye, Stizostedion vltreum vitreum Material: Two pieces of skeletal muscle
Habitat: Lake Medina, Texas
Diagnosis: Myof ibrogranuloma Submitter: J. L. Millard
-11-
RTLA 2064. Fowler’s toad, Bufo fowler 1
|
Material: |
Partially dissected animal; 10 electron microscope blocks |
|
Habitat : Diagnosis : |
Greenville, North Carolina Multifocal dermal pseudocysts (unlined) containing spores, possibly of a sporozoan |
|
Submitter: |
J. S. Laurie |
|
RTLA 2065-2068. Material: Habitat : |
Dover sole. Micros tomus pacificus One microslide each of skin lesions Palos Verdes peninsula. Southern California, near |
|
Diagnosis: |
sewage outfall Amebic "X cell" pseudotumor; secondary trematode in RTLA 2065 and RTLA 2068 |
|
Submitter: |
S . Cohen |
RTLA 2069. Basilisk, Basiliscus plumif rons
|
Material: |
One paraffin block containing tissue from a subcuta¬ neous dorso-lateral growth |
|
Habitat: Diagnosis: Submitter : |
Basel Zoo, Basel, Switzerland Fibrosarcoma A. Heldstab |
RTLA 2070. Boa constrictor. Boa constrictor
|
Material: |
One paraffin block containing tissue from a growth on the hard palate which had coalesced with the nasal septum |
|
Diagnosis : Submitter : |
Malignant melanoma, epithelioid type, amelanotic A. Heldstab |
RTLA 2071. Darter goby, Goblonellus boleosoma
Material: Two microslides of thyroid tissue
Habitat: Aquarium
Diagnosis: Goiter Submitter: J. A. Couch
RTLA 2072. King snake, Lampropeltis getulus f loridanus
|
Material: Diagnosis: |
Fourteen paraffin blocks; 1 color transparency Parasitism by the pentastomld, Roilletlella bicaudata (nymph) |
|
Submitter : |
E. Elkan |
RTLA 2073. Iguana, Iguana iguana
|
Material : Habitat : Diagnosis: Submitter: |
One microslide; 1 color transparency Captive specimen Myxoma F. L. Frye |
RTLA 2074. Coho salmon, Oncorhynchus kisutch
|
Material: Habitat : Diagnosis: Submitter: |
Four microslides; 1 black and white photograph Credit River, Lake Ontario Neurilemmoma R. D. Moccia |
-12-
RTLA 2075. Cichlid, Pelviciachromis sp.
Mc'.terial: One microslide
Habitat: Aquarium
Diagnosis: Exophthalmos — probably due to worm parasites
Submitter: G. C. Blasiola, Jr.
RTLA 2076. Kci Material: Habitat : Diagnosis:
Submitter:
carp, Cyprinus carpio Tissue from growth on the snout Private outdoor pond
Epithelial hyperplasia with underlying chronic inflam¬ matory reaction G. C. Blasiola, Jr.
RTLA
2077. Worm Material: Habitat : Diagnosis : Submitter:
(parasitic) , Otodistomum plunketi Whole animal; 1 microslide Body cavity of a shark Gang lioneurob las toma D. I. Gibson
RTLA 2078. Black bullhead, Ictalurus melas
Material: Growth located in muscle tissue; drawing
Habitat: Jefferson County, Kansas
Diagnosis: Fibroma Submitter: J. Goudzwaard
RTLA 2079. American oyster, Crassostrea virginica
Material: Section of heart tissue; 3 microslides; 2 pathology
reports; drawing
Habitat: Upper Chesapeake Bay — downstream from Susquehana
River
Diagnosis: Dysmorphogenic anomaly of cardiac muscle Submitter: S. V. Otto
RTLA 2080. Leatherjacket , Ollgoplites saurus
Material: Fish head with crooked mandible
Habitat: North Bisca3me Bay, Miami, Florida
Diagnosis: Wound repair
Submitter: W. Kandrashoff
RTLA 2081. Atlantic needlefish, Strongylura marina
Material: Fish head with growth encircling lower jaw
Habitat: North Biscayne Bay, Miami, Florida
Diagnosis: Ulcerated fibrosis containing metazoan parasites Submitter: W. Kandrashoff
RTLA 2082. Pinfish, Lagodon rhomboides
Material: Posterior portions of 2 fish
Habitat: North Biscayne Bay, Miami, Florida
Diagnosis: Scale disorientation
Submitter: W. Kandrashoff
-13-
RTLA 2083. Blue mussel, Mytllus edulis
|
Material: Habitat : |
Seventy live animals Roosevelt Inlet at mouth of Canary Creek, Lewes, Delaware |
|
Diagnosis ; |
Rickettsia-like organism in digestive diverticula cells (one animal) |
|
Submitter: |
R. P. Higgins |
RTLA 2084. Yellowfin sole, Liman da aspera
|
Material: |
Piece of skin and muscle tissue with embedded cyst-like growths; metacercariae; 2 black and white photographs |
|
Habitat : Diagnosis: Submitter: |
Auke Bay, Alaska Parasitism by the trematode, Stephanostomum sp. H. L. Ching |
|
RTLA 2085-2087. Material: |
Hard clam (quahog), Mercenaria mercenaria Three microslides each; 1 paraffin block each (blocks returned to submitter after sections were cut) |
|
Habitat : |
Dutch Island Harbor, lower Narragansett Bay, Rhode Island (relatively unpolluted) |
|
Diagnosis : |
Germinoma, electron microscopy of nuclear inclusions negative for virus particles |
|
Submitter : |
H. Diamond |
|
RTLA 2088-2090. Material: |
Hard clam (quahog) Mercenaria mercenaria Three microslides each; 1 paraffin block each (blocks returned to submitter after sections were cut) |
|
Habitat : |
Saunderstown, lower Narragansett Bay, Rhode Island (in the vicinty of a sewage outfall) |
|
Diagnosis : |
Germinoma, electron microscopy of nuclear Inclusions negative for virus particles; chlamydia inclusions in digestive diverticula cells of RTLA 2088 and RTLA 2090 |
|
Submitter : |
H. Diamond |
RTLA 2091. Soft clam, Mya arenarla
|
Material: Habitat : Diagnosis : |
Fifty- three live clams Searsport, Maine (petroleum spill site) Germinoma (3 animals) ; rickettsia with phage in di¬ gestive diverticula cells (one animal) |
|
Submitter : |
J. C. Harshbarger, J. Hurst, and R. Dow |
RTLA 2092. Blue mussel, Mytilus edulis
|
Material: |
Fifty live mussels |
|
Habitat : Diagnosis : Submitter: |
Searsport, Maine (petroleum spill site) "Normal” J. C. Harshbarger, J. Hurst, and R. Dow |
RTLA 2093. Mexican axolotl, Amby stoma mexicanum
|
Material: |
Carcass and dissected tissues from the liver, heart, spleen, gut, kidney, lung, skin, and dorsal tall fin |
|
Habitat : Diagnosis : Submitter: |
Laboratory reared "Normal" L. E. DeLanney |
-14-
RTLA 2094. Sea fan (gorgonlan) , Gorgonia ventallna Material: Two skeletal branches with lesions
Habitat: Carrie Bow Cay, Belize, Central America
Diagnosis: Gorgonin pearl in response to algal infection
Submitter: K. Muzik and J. N. Norris
RTLA 2095. Striped mullet, Mugil cephalus
Material: Head with a growth in the region of the left eye and
left side of the upper lip Habitat: Auckland Region, New Zealand
Diagnosis: Neurofibroma Submitter: N. Boustead
RTLA 2096. South African clawed frog, Xenopus laevis Material: Enlarged spleen
Diagnosis: Splenomegaly; tissue unsuitable for diagnosis
Submitter: R. Verhoeff-de Fremery
RTLA 2097. Green turtle, Chelonia mydas
Material: Two growths removed from the ventral neck region; 1
color transparency
Habitat: Trig Island, French Frigate Shoals, Northwestern
Hawaiian Islands Diagnosis: Fibropapilloma Submitter: G. H. Balazs
RTLA 2098. Chinook (king) salmon, Oncorhynchus tshawytscha Material: Piece of tissue from one of nine growths
Habitat: Rampart on the Yukon River, Alaska
Diagnosis: Lipoma Submitter: K. A. Neiland
RTLA 2099. Shrimp, Pandalus borealis
Material: Two whole animals — one "normal"; one with a bulging
carapace in the region of the right gill Habitat: Japan Sea (Rebun Pile)
Diagnosis: Gill chamber parasitized by a bopyrid isopod Submitter: T. Harada, K. Oishi, and S. Yamamoto
RTLA 2100. Blue Material: Habitat: Diagnosis : Submitter:
hake, Antimora microlepis
Tissue with internal cyst-like lesions
Pacific Ocean, near Erimo Cape, Hokkaido, Japan
Pseudocyst
T. Harada, K. Oishi, and S. Yamamoto
RTLA 2101. Walleye pollock, Theragra chalcogramma Material: Viscera
Habitat: Pacific Ocean
Diagnosis: Parasitism by Anisakis sp. and Nybelinia surmenicola Submitter: T. Harada, K. Oishi, and S. Yamamoto
-15-
RTLA 2102-2105. Material:
Habitat : Diagnosis : Submitter:
Crevalle jack, Caranx hippos
Various portions of four animals including head, mid section, and tail, with nodular or ulcerated lesions or lesions embedded in the skin and musculature North Blscayne Bay, Miami, Florida (RTLA 2103-2105) Inflammation due to bacterial infection W. Kandrashoff
RTLA 2106. Rabbitfish, Slganus fuscescens
Material: Two microslides; 1 black and white photograph
Habitat: Ueno Zoo Aquarium, Japan
Diagnosis: Goiter
Submitter: Prince Masahito Hitachi
RTLA 2107. Goby Material: Habitat :
Diagnosis: Submitter :
Favonigobius g3nnnauchen One microslide; 1 black and white photograph Captured in Hamana Lake, Shizuoka Prefecture in 1976 kept in aquarium for about one year Squamous polyp Prince Masahito Hitachi
RTLA 2108. Rhinoceros iguana, Cyclura cornuta
Material: Nine microslides; 1 black and white photograph
Habitat: Ueno Zoo Aquarium, Japan
Diagnosis: Hyperplastic osteochondrodystrophy Submitter: Prince Masahito Hitachi
RTLA
2109. Goby, Material: Habitat : Diagnosis : Submitter:
Rhinogoblus brunneus
One microslide; 1 black and white photograph A river on Yaku Island (southern Japan) Amebic '*X cell" pseudotumor Prince Masahito Hitachi
RTLA 2110. Sandbar shark, Carcharhinus milberti
Material: Two microslides; 2 black and white photographs
Habitat: Ueno Zoo Aquarium, Japan
Diagnosis: Goiter versus thyroid carcinoma Submitter: Prince Masahito Hitachi
RTLA 2111. Cichlid, Pseudotropheus zebra
Material: One microslide; 1 black and white photograph
Habitat: Ueno Zoo Aquarium, Japan
Diagnosis: Hepatocellular carcinoma
Submitter: Prince Masahito Hitachi
RTLA 2112. Red-tail catfish, Phractocephalus hemillopterus
Material: One microslide; 1 black and white photograph
Habitat: Ueno Zoo Aquarium, Japan
Diagnosis: Lipoma
Submitter: Prince Masahito Hitachi
-16-
RTLA 2113. Denticle herring, Clupanodon punctatus
|
Material: Habitat: Diagnosis : Submitter : |
One microslide; 2 black and white photographs Tokyo Bay, Japan Fibroma Prince Masahito Hitachi |
RTLA 2114. Malayan monitor, Varanus salvator
Material: Six microslides; 1 black and white photograph
Habitat: Ueno Zoo, Japan
Diagnosis: Fibroma
Submitter: Prince Masahito Hitachi
RTLA 2115. Spotted gar, Lepisosteus oculatus
|
Material: Habitat : Diagnosis : Submitter : |
One microslide; 2 color photographs Commercial source, Japan Epidermal papilloma Prince Masahito Hitachi |
RTLA 2116. Coho salmon, Oncorhynchus kisutch
|
Material: Habitat: Diagnosis : Submitter: |
Two microslides; 2 black and white photographs Hatchery reared, Japan Poorly-differentiated ependymob la stoma Prince Masahito Hitachi |
|
RTLA 2117-2122. Material: |
Coho salmon, Oncorhynchus kisutch One microslide each (RTLA 2117-2119) ; 2 micro- slides each (RTLA 2120-2122); 2 color transparen¬ cies representing the six cases |
|
Habitat : Diagnosis: Submitter: |
Two sites in Brittany, France Cataract; lens epithelial hyperplasia G. Balouet and F. B. Laurencin |
RTLA 2123. South African clawed frog, Xenopus laevis
|
Material: |
Two microslides of kidney and liver tissue ex¬ |
|
Habitat : Diagnosis : |
perimentally treated with N-nitrosodimethylamine Laboratory Cholangiocarcinoma, cholangiof ibrosls, nephrosis, hepatocellular carcinoma, and renal adenocarcinoma |
|
Submitter: |
V. V. Khudoley |
RTLA 2124. South African clawed frog, Xenopus laevis
|
Material: |
One microslide of kidney and liver tissue ex¬ perimentally treated with N-nitrosodlmethylamine |
|
Habitat : Diagnosis : |
Laboratory Cholangiocarcinoma, early renal adenocarcinoma, and nephritis |
|
Submitter: |
V. V. Khudoley |
RTLA 2125. South African clawed frog, Xenopus laevis
|
Material: |
One microslide of kidney and liver tissue ex¬ perimentally treated with N-nitrosodimethylamine |
|
Habitat : Diagnosis: |
Laboratory Cholangiocarcinoma, anaplastic renal cancer, diffuse, focal proliferation of hepatocytes, and cholangiof ibrosis |
|
Submitter: |
V. V. Khudoley |
-17-
RTLA
2126. South African clawed frog, Xenopus laevls
Material: One microslide of kidney and liver tissue experimentally
treated with N-nitrosodimethylamine Habitat: Laboratory
Diagnosis: Cholangiocarcinoma, cholangiof ibrosis, and hepatocel¬
lular carcinoma Submitter: V. V. Khudoley
RTLA 2127. Grass frog, Rana temp or aria
Material: One microslide of skin growths
Habitat: Leningrad area, USSR
Diagnosis: Cyst adenoma of mucus or poison gland ducts Submitter: V. V. Khudoley
RTLA 2128. Bluefin tuna, Thunnus thynnus
Material: One microslide of muscle tissue; 1 paraffin block
Diagnosis: Parasitism by the myxosporidan, Kudoa sp. Submitter: B. L. Munday
RTLA 2129. Rainbow trout, Salmo galrdneri
Material: Seven microslides: thymus, gill, liver, and kidney tissue
Habitat: Montana State Fish Hatchery
Diagnosis: Malignant thymic lymphoma; gill granulomas Submitter: C. E. Smith
RTLA 2130. Pine Material: Habitat : Diagnosis : Submitter :
snake, Pituophis melanoleucus Two microscope slides
Ft. Worth Zoological Park, Ft. Worth, Texas Invasive iridophoroma E. Jacobson
RTLA 2131. Axolotl, Amby stoma sp.
Material: A growth which had been attached to the liver and oviduct
Diagnosis: Bacterial granuloma Submitter: R. Verhoeff-de Fremery
RTLA 2132. American oyster, Crassostrea virginica Material: Four microslides
Habitat: Pascagoula, Mississippi
Diagnosis: Hematopoietic neoplasm; parasitism by Nemotopsis spores and Dermocystidium hypnospores Submitter: J. A. Couch
RTLA 2133. Boa constrictor. Boa constrictor
Material: Three pieces of tissue; 2 microslides (smears)
Habitat: Pet; California
Diagnosis: Possible gastrointestinal mucoadenocarcinoma based
on clinical signs and exfoliative cytology Submitter: I. Gorman
RTLA 2134. Siamese fighting fish, Betta splendens
Material: One partly dissected fish; cyst-like growth removed
from the visceral cavity Habitat: Aquarium; New Zealand
Diagnosis: Multiple granulomas of possible mlcrosporidan etiology Submitter: S. G. Pullan
TEAR OUT ACCESSION SHEET
PLEASE SUBMIT TO:
Dr. John C. Harshbarger Registry of Tumors in Lower Animals National Museum of Natural History Room W216-A
Smithsonian Institution Washington, D.C., 20560, USA
COMMON NAME _ _ _ FAMILY _
PHYLUM _ _ GENUS
CLASS _ SPECIES _ _ _ _
ORDER _
CATEGORY: NEOPLASM _ _ INFLAMMATION _ INFECTION _ _ PAPAS ITIC _ TOXIC
DEVELOPMENTAL _ TRAUMATIC _ NORMAL _ _ OTHER __
CONTRIBUTOR (NAME & ADDRESS): COLLECTOR (NAME & ADDRESS):
DATE RECD. _
CONTRIBUTOR'S NO,
RTLA NO. _
USNM NO, ___ NIH HISTOPATH NO.
ITEMS SUBMITTED (QUANTITY):
GROSS MATERIAL _ PHOTOGRAPHS _ _
SLIDES _ - REPRINTS _
BLOCKS _ OTHER _
ORIGIN OF ANIMAL: MARINE _ FRESHWATER _ ESTAURINE _ TERRESTRIAL
WHERE COLLECTED _ _
date collected _ SEX _ AGE _ _ STAGE OF LIFE CYGLE
HOW KILLED _ FIXATION _
GROSS DESCRIPTION _
MICROSCOPE DX
COMMENTS (e.go, possible exposure to chemical pollutants or infectious agents, in¬ cidence and duration of this condition in the population, etc.)
(Please use reverse side, if more space is needed)
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-20-
RTLA 2153. Amazon molly, Poecllia formosa
Material: Whole animal treated with anthracene
Habitat: Brookhaven National Laboratory, Upton, New York
Diagnosis: Ectopic hyperplastic thyroid in spleen Submitter: A. D. Woodhead
RTLA 2154. Rainbow trout, Salmo galrdneri
Material: Two pieces of tissue from a kidney growth
Habitat: Duck Lake, Montana
Diagnosis: Nephroblastoma Submitter: C. E. Smith
RTLA 2155. Common bream, Abramis brama
Material: Two pieces of liver tissue
Habitat: Rhinewater, The Netherlands
Diagnosis: Hepatocellular carcinoma Submitter: W. Slooff
RTLA 2156. Pink salmon, Oncorhynchus gorbuscha
Material: Two pieces of tissue from a growth on the dorsal surface
of the fish
Habitat: Port Hardy, Vancouver Island, B.C., Canada
Diagnosis: Neurofibroma Submitter: G. R. Bell
RTLA 2157. Sydney rock oyster, Crassostrea commercialis Material: Four whole animals
Habitat: Greenwell Point, Australia
Diagnosis: Mantle papillomas Submitter: P. H. Wolf
RTLA 2158. Spot, Leiostomus xanthurus
Material: One microslide; 2 black and white photographs
Diagnosis: Giant islet Submitter: J. A. Couch
RTLA 2159. Atlantic cutlassfish, Trichiurus lepturus Material: One microslide
Habitat: Mobile Bay, Alabama
Diagnosis: Granulomatous osteomyelitis Submitter: J. A. Gouch
RTLA 2160. Silver shad
Material: Viscera: ’’normal” and pathologic
Habitat: North Biscayne Bay, Miami, Florida
Diagnosis: Old, multiple granulomas in the mesentery and within ovarian follicles Submitter: W. Kandrashoff
-21-
RTLA 2161. Pill bug
|
Material: Habitat : Diagnosis : |
Nine whole animals — some bright blue when alive San Diego Zoo, San Diego, California Mermithid nematode infestation with associated host cellular response |
|
Submitter : |
G. E. Cosgrove |
RTLA 2162. Catfish
Material: Both eyes (blind); floor of mouth (enlarged)
Habitat: Fish farm, Hawaii
Diagnosis: Keratoconjunctivitis; hemorrhage and edema of jaw Submitter: G. E. Cosgrove
RTLA 2163. Zebrafish, Zebrasoma f lavescens
|
Material : |
Slice through the head including the eyes; posterior portion of the fish |
|
Diagnosis : |
Surface infestation of small turbellarlans , possibly |
|
Submitter : |
Ichthyphaga subcutanea G. E. Cosgrove |
RTLA 2164. Catfish, Ictalurus sp. (?)
|
Material: |
Head with multiple, very firm, nodular growths on the lips; viscera |
|
Habitat : Diagnosis : |
San Diego River, San Diego, California Traumatic osteomyelitis associated with areas of epidermal and melanophore hyperplasia |
|
Submitter: |
G. E. Cosgrove |
RTLA 2165. Spiny dogfish, Squalus acanthias
|
Material : Habitat : Diagnosis: Submitter: Reprint : |
One paraffin block of thyroid tissue Frenchman’s Bay, Maine Colloid adenoma A. D. Woodhead Woodhead, A. D. and P. M. J. Woodhead. 1979. (1980). A thyroid neoplasm in the spiny dogfish, Squalus acanthias. Bull. Mt. Desert Is. Biol. Lab., 19: 19-21. |
RTLA 2166. Channel catfish, Ictalurus punctatus
|
Material: Habitat: Diagnosis: Submitter: |
Two pieces of tissue from a growth in the abdominal cavity Crisp County, Georgia Plasmacytoma J. Grizzle |
RTLA 2167. Dolphin (fish), Coryphaena hippurus
|
Material: Habitat : Diagnosis : |
Four vertebrae and associated tissue Off Miami Beach, Florida, in the Gulf Stream Fracture of centrum of 2 vertebrae with exuberant callus formation |
|
Submitter: |
W. Kandrashoff |
-22-
RTLA 2168. Dover sole, Mlcrostomus paclf icus
|
Material: |
Four microslides; 3 paraffin blocks of swelling in the vicinity of the peritoneal cavity; 1 color transparency; 2 black and white photographs |
|
Habitat : Diagnosis; Submitter : |
Off Cape Mendocino, California Malignant melanoma R. W. Warner |
RTLA 2169. Dover sole, Mlcrostomus pacif icus
|
Material: |
Three microslides; 2 paraffin blocks of growth protruding from both the eyed and the blind side of the fish; 3 black and white photographs |
|
Habitat; Diagnosis : Submitter: |
Eureka, California area Neur of ibrosarcoma R. W. Warner |
RTLA 2170. Dover sole, Mlcrostomus pacif icus
|
Material: |
Two microslides of lobulated, pedunculated growth at¬ tached to operculum; 3 black and white photographs |
|
Habitat ; Diagnosis: |
Off Cape Mendocino, California Multiloculated fibrolipoma (or f ibrolipohamartoma) en¬ veloping scales |
|
Submitter: |
R. W. Warner • • |
RTLA 2171. Lingcod, Ophlodon elongatus
|
Material: |
Two microslides; 2 paraffin blocks of growth embedded in the musculature near the visceral cavity; 3 black and white photographs |
|
Habitat ; Diagnosis : Submitter; |
Off the Eureka-Crescent City, California area Lipoma R. W. Warner |
RTLA 2172. Lingcod, Ophiodon elongatus
|
Material: |
Two microslides; 1 paraffin block of growth attached to the mesenteries; 1 black and white photograph |
|
Habitat: Diagnosis: Submitter: |
Off Patrick's Point, Humboldt County, California Fibrolipoma R. W. Warner |
RTLA 2173. Lingcod, Ophiodon elongatus
|
Material: |
One microslide; 2 paraffin blocks of growth attached by mesenteries to the liver; 2 black and white photographs |
|
Habitat ; Diagnosis : Submitter: |
Eureka, California area Lipoma containing multiple microscopic granulomas R. W. Warner |
RTLA 2174. Lingcod, Ophiodon elongatus
|
Material: |
One microslide; 1 paraffin block of protuberance on the head; 2 black and white photographs |
|
Habitat: Diagnosis: Submitter; |
Fort Bragg, California area Neurilemmoma R. W. Warner |
-23-
RTLA 2175. Shortspine thornyhead, Sebastolobus alascanus
Material:
Habitat : Diagnosis : Submitter:
Two microslides of pedunculated growth attached to base of left pectoral fin; 4 black and white photo¬ graphs
Between Cape Sebastian and Cape Ferrelo, Oregon
Myxofibroma
R. W. Warner
RTLA 2176. Shortspine thornyhead, Sebastolobus alascanus
Material: One microslide of growth protruding from the cleft of the
premaxillary; 1 color transparency; 4 black and white photographs
Habitat: Eureka, California area
Diagnosis: Compound odontoma
Submitter: R. W. Warner
RTLA 2177. Yellowtail rockfish, Sebastes f lavldus
Material:
Habitat:
Diagnosis;
Submitter;
Two microslides; 1 paraffin block of growth on the soft- rayed portion of the dorsal fin; 1 black and white photo¬ graph
Off the Oregon coast
Lipoma
R. W. Warner
RTLA 2178. Vermilion rockfish, Sebastes minlatus
Material:
Habitat : Diagnosis: Submitter :
Two microslides; 2 paraffin blocks of growth located in the mid-dorsal portion of the right side of the fish; 3 black and white photographs Plaskett Rock, Morro Bay, California Lipoma
R. W. Warner
RTLA 2179. Black cod (sablefish), Anoplopoma fimbria
Material:
Habitat:
Diagnosis:
Two microslides; 1 paraffin block of growth pressed against
lateral musculature, left abdominal cavity; 2 black and
white photographs
Off the Eureka, California area
Fibroma
Submitter: R. W. Warner
RTLA 2180. Black cod (sablefish), Anoplopoma fimbria
Material: One microslide of a growth protruding from the snout; 2
black and white photographs Habitat: Off Cape Blanco, Oregon
Diagnosis: Neurofibroma Submitter: R. W. Warner
RTLA 2181. English sole, Parophrys vetulus
Material: Two microslides of a growth located in the musculature
between the vertebral column and the base of the dorsal fin; 2 black and white photographs Habitat: Off the San Francisco, California area
Diagnosis: Fibroma Submitter: R. W. Warner
-24-
RTLA 2182. Ribbed newt, Pleurodeles waltlii
|
Material : Habitat : Diagnosis : Submitter: |
Six microslides; 5 black and white photographs Laboratory reared Nephroblastoma W. JMnisch |
|
RTLA 2183-2187. Material : Habitat : |
Sydney rock oyster, Crassostrea commercialis Two microslides each Greenwell Point, near Nowra, New South Wales, Australia |
|
Diagnosis: Submitter: |
Mantle papillomas P. H. Wolf |
RTLA 2188. Roach, Rutilus rutllus
Material: One paraffin block of enlarged thyroid gland
Diagnosis: Well-differentiated colloid adenoma Submitter: W. Slooff
RTLA 2189. Angelfish, Pterophyllum scalare
|
Material : |
Fish head with a nodular growth on the mouth; tissue bits of the growth |
|
Diagnosis: |
Reactive hyperplasia with tooth formation — probably traumatic |
|
Submitter : |
G. C. Blasiola, Jr. |
RTLA 2190. Chuckwalla, Sauromalus obesus
|
Material: |
Lower jaw with spherical growth embedded in the fascia between the skin and the throat musculature; reprint |
|
Diagnosis : Submitter : Reprint : |
Huge multifocal ulcerated bacterial granuloma A . Klempau Bostic, D. L. 1971. Observations on the tumor-like growths in the chuckwalla, Sauromalus varius. J. Herpetol., 5: 76-78. |
|
RTLA 2191-2193. Material: Habitat : Diagnosis : |
Leopard frog, Rana pipi^ns One femur each Wisconsin Callus formation around a fracture which may be calcium deficient |
|
Submitter: |
A. Klempau |
RTLA 2194. Blue mussel, Mytilus edulis
|
Material: Habitat : |
One microslide Inlet polluted by pulpmill effluent in British Columbia, Canada |
|
Diagnosis : |
Granuloma; hemocyte nodules in the digestive diver¬ ticula and connective tissue due to parasitlzation by worm |
-25-
RTLA 2195. Blue mussel, Mytllus edulls Material: One mlcrosllde
Habitat: Inlet polluted by pulpmill effluent in British
Columbia, Canada
Diagnosis: Generalized disseminated inflammatory reaction due to worms (Trematoda) in gut, a fluke in connective tissue and ciliates, Ancistrocoma sp., on the gills Submitter: W. A. Heath
RTLA 2196. Blue mussel, Mytilus edulis Material: One mlcrosllde
Habitat: Inlet polluted by pulpmill effluent in British
Columbia, Canada Diagnosis: Parasites in gut Submitter: W. A. Heath
RTLA 2197. Blue mussel, Mytilus edulis Material: One microslide
Habitat: Inlet polluted by pulpmill effluent in British
Columbia, Canada
Diagnosis: Parasites in gills and kidney Submitter: W. A. Heath
RTLA 2198. Blue m.ussel, Mytilus edulis Material: One microslide
Habitat: Inlet polluted by pulpmill effluent in British
Columbia, Canada Diagnosis: Parasites in gills Submitter: W. A. Heath
RTLA 2199, 2200. Material : Habitat:
Diagnosis : Submitter:
Blue mussel, Mytilus edulis One microslide each
Inlet polluted by pulpmill effluent in British Columbia, Canada "Normal" controls W. A. Heath
RTLA 2201. Blue mussel, Mytilus edulis Material: One mlcrosllde
Habitat: Inlet polluted by pulpmill effluent in British
Columbia, Canada
Diagnosis: Granulomas in foot muscle and digestive diverticula
Submitter: W. A. Heath
RTLA 2202. Blue mussel, Mytilus edulis Material: One microslide
Habitat: Inlet polluted by pulpmill effluent in British
Columbia, Canada
Diagnosis: Distal obstruction of the gut
Submitter: W. A. Heath
-26-
RTLA 2203. Blue mussel, Mytilus edulis
|
Material : Habitat : |
One microslide Inlet polluted by pulpmill effluent in British Columbia, Canada |
|
Diagnosis ; Submitter : |
Diffuse massive eroding inflammatory reaction W. A. Heath |
RTLA 2204. Blue mussel, Mytilus edulis
|
Material: Habitat : |
One microslide Inlet polluted by pulpmill effluent in British Columbia, Canada |
|
Diagnosis : Submitter: |
Foot granuloma; tubule inflammation (digestive diverticula) W. A. Heath |
RTLA 2205. Blue mussel, Mytilus edulis
|
Material : Habitat : |
One microslide Inlet polluted by pulpmill effluent in British Columbia, Canada |
|
Diagnosis: |
Digestive diverticula degeneration with tubule destruction; |
|
Submitter : |
granuloma W. A. Heath |
RTLA 2206. Blue mussel, Mytilus edulis
|
Material: Habitat : |
One microslide Inlet polluted by pulpmill effluent in British Columbia, Canada |
|
Diagnosis : |
Massive inflammation digestive diverticula; tubule destruction |
|
Submitter : |
W. A. Heath |
RTLA 2207. Blue mussel, Mytilus edulis
|
Material: Habitat : |
One microslide Inlet polluted by pulpmill effluent in British Columbia, Canada |
|
Diagnosis : Submitter : |
Inflammation and degeneration of digestive diverticula W. A. Heath |
RTLA 2208. Cottonmouth, Agkistrodon piscivorus
|
Material: Habitat : Diagnosis : Submitter : |
One microslide Zoological Society of London Hemangioendothelioma J. E. Cooper |
RTLA 2209. Monarch butterfly, Danaus plexippus
|
Material: Habitat : |
Live animal with greatly enlarged abdomen Insect Zoo, National Museum of Natural History, Smithsonian Institution, Washington, D. C. |
|
Diagnosis : Submitter : |
Ascites; etiology unknown B. Daniels |
-27-
RTLA 2210. Rainbow trout, Salmo gairdneri
Matprial: Two pieces of tissue from a kidney growth;
1 color transparency Habitat: Holter Reservoir, Montana
Diagnosis: Nephroblastoma Submitter: C. E. Smith
1 mlcrosllde
RTLA 2211. Coho Material: Habitat :
Diagnosis : Submitter :
salmon, Oncorhynchus klsutch
Piece of thyroid tissue; 1 mlcrosllde
Probably Lake Erie (via Falrvlew, Pennsylvania State
Fish Hatchery)
Goiter C. E. Smith
RTLA 2212. Coho Material: Habitat :
Diagnosis: Submitter :
salmon, Oncorhynchus klsutch
Piece of thyroid tissue with attached gill
Probably Lake Erie (via Falrvlew, Pennsylvania State
Fish Hatchery)
Goiter versus thyroid carcinoma C. E. Smith
RTLA 2213. Brown trout, Salmo trutta
Material: Six mlcroslldes; 2 color transparencies
Habitat: Hamilton Harbour, Lake Ontario
Diagnosis: Gill hamartoma Submitter: R. D. Moccla
RTLA 2214. Rainbow trout, Salmo gairdneri
Material: Two mlcroslldes of a lesion In the pyloric cecal area
Habitat: Hagerman Valley, Idaho
Diagnosis: Infarction of portion of gastrointestinal tract; enteritis
Submitter: T. N. Otto
RTLA 2215. Pink salmon, Oncorhynchus gorbuscha
Material: One mlcrosllde; 1 color photograph; 4 black and white
photographs
Habitat: Mori Hatchery, Hokkaido, Japan
Diagnosis: Epidermal papilloma
Submitter: T. Awakura
RTLA 2216. Rainbow trout, Salmo gairdneri Material: Three mlcroslldes
Diagnosis: Ichthyosporldlum (= Ichthyophonus) Infection In kidney
Submitter: T. Awakura
RTLA 2217. Brown trout, Salmo trutta
Material: Five pieces of tissue, each with a growth; 2 color
transparencies
Habitat: Lake Sedgemere, South Island, New Zealand
Diagnosis : Malignant neurilemmoma Submitter: N. Boustead
-^28-
RTLA 2218. Rainbow trout, Salmo galrdneri
|
Material: |
Epidermis with half of an attached stalked cyst-like growth; a piece of the cyst-like growth |
|
Habitat : Diagnosis : |
Lake Taupo, North Island, New Zealand Pedunculated scar and granulation tissue; etiology unknown |
|
Submitter: |
N. Boustead |
RTLA 2219. South African clawed frog, Xenopus laevis
|
Material: |
Eight microslides; 6 black and white photographs; 9 electron micrographs |
|
Habitat : Diagnosis : Submitter: |
Laboratory bred Granular cell myoblastoma W. Janisch and Th. Schmidt |
-29-
INDEX OF NEOPLASTIC AND HYPERPLASTIC LESIONS - ANIMAL GROUP - AND RTLA NUMBER
Amebic "X cell" pseudotumor: Bony fish - RTLA 2109, 2065-2068 Anaplastic renal cancer: Amphibian - RTLA 2125 Astrocytoma: Bony fish - RTLA 2047 Cataract: Bony fish - RTLA 2117-2122 Cholangiocarcinoma: Amphibian - RTLA 2123-2126 Chromatophoroma :
Erythrophoroma: Bony fish - RTLA 2052 Iridophoroma (invasive) : Reptile - RTLA 2130
Melanophoroma (Invasive): Reptile - RTLA 2070; Bony fish - RTLA 2141, 2168
Colloid adenoma: Bony fish - RTLA 2188; Cartilaginous fish - RTLA 2165
Compound odontoma: Bony fish - RTLA 2176
Cuticular epithelium hyperplasia: Annelid - RTLA 2045
Cyst adenoma: Amphibian - RTLA 2127
Ependymob la stoma: Bony fish - RTLA 2116, 2047
Epidermal and melanophore hyperplasia: Bony fish - RTLA 2164
Epidermal cyst: Bony fish - RTLA 2136
Epithelial hyperplasia: Bony fish - RTLA 2076; Mollusk - RTLA 2147
Esthesioneuroeplthelioma: Bony fish - RTLA 2051
Fibrolipoma (f ibrollpohamartoma) : Bony fish - RTLA 2170, 2172
Fibroma/Fibrosarcoma: Reptile - RTLA 2069, 2114; Bony fish - RTLA 2055, 2062, 2078, 2113, 2179, 2181
Fibropapilloma: Reptile - RTLA 2097
Ganglioneuroblastoma: Flatworm - RTLA 2077
Germlnoma: Mollusk - RTLA 2085-2091, 2137-2139
Gill hamartoma: Bony fish - RTLA 2213
-30-
Goiter; Bony fish - RTLA 2058, 2071, 2106, 2211; 2151-2153 (ectopic); Cartilaginous fish - RTLA 2061
Goiter versus thyroid carcinoma: Bony fish - RTLA 2212; Cartilaginous fish - RTLA 2110
Granular cell myoblastoma: Amphibian - RTLA 2219
Hemangioendothelioma: Reptile - RTLA 2208; Bony fish - RTLA 2140
Hematopoietic neoplasm: Mollusk - RTLA 2132
Lymphoma (malignant) : Bony fish - RTLA 2129
Plasmacytoma: Bony fish - RTLA 2166
Hepatoma/Hepatocellular carcinoma: Amphibian - RTLA 2123, 2126; Bony fish - RTLA 2111, 2145, 2146, 2149, 2150, 2155
Hyperplastic osteochondrodystrophy: Reptile - RTLA 2108
Islet: Bony fish - RTLA 2158
Lipoma: Bony fish - RTLA 2098, 2112, 2171, 2173, 2177, 2178 Mesothelioma: Bony fish - RTLA 2043 Mucoadenocarcinoma: Reptile - RTLA 2133 Myxofibroma: Bony fish - RTLA 2175 Myxoma; Reptile - RTLA 2073
Nephroblastoma: Amphibian - RTLA 2182; Bony fish - RTLA 2154, 2210
Neurilemmoma: Bony fish - RTLA 2049, 2053, 2074, 2174; 2142, 2217 (in¬ vasive)
Neurofibroma /Neurofibrosarcoma: Bony fish - RTLA 2095, 2156, 2169, 2180 Papilloma:
Epidermal: Bony fish - RTLA 2115, 2143, 2215 Mantle: Mollusk - RTLA 2157, 2183-2187 2180
Polycystic kidney: Bony fish - RTLA 2053
Reactive hyperplasia: Bony fish - RTLA 2050, 2057, 2135, 2189; Coelen- terate - RTLA 2094
Renal adenocarcinoma: Amphibian - RTLA 2123, 2124 Squamous polyp: Bony fish - RTLA 2107
PHYLOGENETIC INDEX
PHYLUM CHORDATA Class Reptilia
Order Squama ta (lizards, snakes) - RTLA 2054, 2069, 2070, 2072, 2073, 2108 2114, 2130, 2133, 2144, 2190, 2208
Order Chelonla (turtles) - RTLA 2042, 2097 Class Amphibia
Order Anura (toads, frogs) - RTLA 2064, 2096, 2123-2127, 2191- 2193, 2219
Order Caudata (axolotls, salamanders, newts) - RTLA 2060, 2093, 2131, 2182
Class Osteiohthyes
Order Pleuronectiformes (flounders, soles) - RTLA 2065-2068, 2084, 2168-2170, 2181
Order Perciformes
Family Belontiidae (gouramies, bettas) - RTLA 2134, 2143
Family Hexagrammidae (greenlings, lingcods) - RTLA 2171-2174
Family Anoplopomatidae (sablef ishes) - RTLA 2179, 2180
Family Scorpaenldae (scorpionf ishes , rockfishes) - RTLA 2175- 2178
Family Scombridae (tunas) - RTLA 2128 Family Trlchiuridae (cutlassf ishes) - RTLA 2159 Family Siganldae (rabbitfishes) - RTLA 2106 Family Acanthuridae (surgeonf ishes) - RTLA 2163 Family Gobiidae (gobies) - RTLA 2071, 2107, 2109 Family Pholidae (gunnels) - RTLA 2136 Family Mugilidae (mullets) - RTLA 2095
Family Cichlidae (cichlids) - RTLA 2075, 2111, 2135, 2140, 2189
-32-
Famlly Sciaenldae (drums) - RTLA 2158
Family Sparidae (porgles) - RTLA 2082
Family Coryphaenldae (dolphins) - RTLA 2167
Family Carangidae (jacks, pompanos) - RTLA 2080, 2102-2105
Family Percldae (perches) - RTLA 2063
Order Atheriniformes (needlefishes, killifishes, livebearers) - RTLA 2058, 2081, 2145, 2146, 2149-2153
Order Gadiformes (codfishes) - RTLA 2047, 2048, 2100, 2101
Order Cyprinif ormes (goldfish, carps, shiners) - RTLA 2050- 2053, 2056, 2057, 2076, 2141, 2155, 2188
Order Salmonif ormes (salmonids) - RTLA 2043, 2049, 2059, 2062, 2074, 2098, 2116-2122, 2129, 2154, 2156, 2210-2218
Order Slluriformes (catfishes, bullheads) - RTLA 2078, 2112, 2162, 2164, 2166
Order Clupeif ormes (shads, herrings, anchovies) - RTLA 2113, 2142, 2160
Order Angulllif ormes (eels) - RTLA 2055 Order Semionot if ormes (gars) - RTLA 2115
Class Chondrichthyes
Order Squalif ormes (sharks) - RTLA 2061, 2110, 2165
PHYLUM ARTHROPODA
Class Inseota (butterflies, true bugs) - RTLA 2209 Class Crustacea (shrimp, isopods) - RTLA 2099, 2161
PHYLUM MOLLUSCA Class Bivalvia
Order Myoida (razor clams) - RTLA 2091
Order Veneroida (common clams) - RTLA 2085-2090, 2137-2139
-33-
Order Mxtilo^ (mussels) - RTLA 2083, 2092, 2147, 2148, 2194-2207
Order Pteriolda (oysters) - RTLA 2079, 2132, 2157, 2183-2187
PHYLUM ANNELIDA
Class Hirudinea (leeches) - RTLA 2044-2046
PHYLUM PLATYHELMINTHES
Class Trematoda (flukes) - RTLA 2077 Class Tux^bellaTia (planarians) - RTLA 2041
PHYLUM COELENTERATA
Class Anthozoa (corals) - RTLA 2094
-34-
INDEX OF SPECIMENS BY SCIENTIFIC AND COMMON NAMES
RTLA Number
A
|
Abramis brama |
2155 |
|
Aequidens pulcher |
2140 |
|
Agkistrodon piscivorus |
2208 |
|
Amazon molly |
2149-2153 |
|
Amby stoma sp. |
2131 |
|
Amby stoma mexicanum |
2093 |
|
Ambystoma tigrinum |
2060 |
|
American oyster |
2079, 2132 |
|
Angelfish |
2135, 2189 |
|
Anoplopoma fimbria |
2179, 2180 |
|
Antimora microlepis |
2100 |
|
Atlantic cutlassfish |
2159 |
|
Atlantic needlefish |
2081 |
|
Axolotl B Basiliscus plumifrons |
2131 ' |
|
2069 |
|
|
Basilisk |
2069 |
|
Betta splendens |
2134 |
|
Bltls gabonica |
2144 |
|
Black bullhead |
2078 |
|
Black cod |
2179, 2180 |
|
Blue acara |
2140 |
|
Blue hake |
2100 |
|
Blue mussel |
2083, 2092 |
|
Bluefin tuna |
2128 |
|
Boa constrictor |
2070, 2133 |
|
Boa constrictor |
2070, 2133 |
|
Brown trout |
2213, 2217 |
|
Bufo fowler i |
2064 |
C
|
Caranx hippos |
2102-2105 |
|
Carassius auratus |
2050, 2051 |
|
Carcharhinus milberti |
2110 |
|
Catfish |
2162, 2164 |
|
Channel catfish |
2166 |
|
Chelonia mydas |
2097 |
|
Chinook salmon |
2098 |
|
Chuckwalla |
2190 |
|
Cichlid |
2075, 2111 |
|
Clupanodon punctatus |
2113 |
2147,
2053,
2194-2207
2057, 2141
-35-
Coalf ish Coho salmon
Common bream Corn snake Coryphaena hlppurus Cottonmouth
Crassostrea commercialis Crassostrea virginica Crevalle jack Cyclura cornuta Cyprinodon varlegatus
Cyprinus carplo
D
Danaus plexippus
Darter goby Denticle herring Dolphin Dover sole Dugesia etrusca
E
Eel
Elaphe guttata guttata Emerald shiner English sole Eretmochelys imbricata Erpobdella octoculata
F
Favonigoblus gymauchen Fowler's toad
G
Gaboon viper Gadus merlangus Gobionellus boleosoma Goby
Goldfish
Gorgonia ventalina Gorgonian Grass frog Green turtle
RTLA Number 2047
2043, 2074, 2116-2122, 2211, 2212 2155 2054 2167 2208
2157, 2183-2187 2079, 2132 2102-2105 2108 2058
2052, 2076
2209
2071
2113'
2167
2065-2068, 2168-2170 2041
2055 2054
2056 2181 2042 2045
2107
2064
2144
2048
2071
2107, 2109
2050, 2051, 2053, 2057, 2141
2094
2094
2127
2097
-36-
RTLA Number
H
|
Hard clam |
2085-2090, |
|
Hawksbill turtle |
2042 |
|
Hemiclepsis marginata |
2044, 2046 |
|
Horse mussel |
2148 |
I
|
Ictalurus sp. |
2164 |
|
Ictalurus melas |
2078 |
|
Ictalurus punctatus |
2166 |
|
Iguana |
2073 |
|
Iguana iguana |
2073 |
|
K |
|
|
King salmon |
2098 |
|
King snake |
2072 ' |
|
Koi carp |
2052, 2076 |
|
L |
|
|
Lagodon rhomboides |
2082 |
|
Lampropeltis getulus floridanus |
2072 |
|
Leather jacket |
2080 |
|
Leech |
2044-2046 |
|
Leiostomus xanthurus |
2158 |
|
Lemon shark |
2061 |
|
Leopard frog |
2191-2193 |
|
Lepisosteus oculatus |
2115 |
|
Limanda aspera |
2084 |
|
Lingcod |
2171-2174 |
M
|
Malabar anchovy |
2142 |
|
Malayan monitor |
2114 |
|
Mercenaria mercenaria |
2085-2090, |
|
Mexican axolotl |
2093 |
|
Microstomus pacificus |
2065-2068, |
|
Modiolus modiolus |
2148 |
|
Monarch butterfly |
2209 |
|
Mugil cephalus |
2095 |
|
Mya arenaria |
2091 |
|
Mytilus edulis |
2083, 2092 |
2137-2139
2137-2139
2168-2170
2147, 2194-2207
N
Negaprion brevirostris
2061
Notropis atherinoides 0
Oligoplites saurus Oncorhynchus gorbuscha Oncorhynchus klsutch Oncorhynchus tshawytscha Ophlodon elongatus Otodistomum plunketi
P
Pandalus borealis Parophrys vetulus Pelviciachromis sp.
Pholis gunnel lus
Phractocephalus hemlliopti
Pillbug
Pine snake
Pinf ish
Pink salmon
Pituophls melanoleucus
Planar ian
Pleurodeles waltlli Poecllia f ormosa Poeciliopsis lucida Pollachius vlrens Pollock
Pseudo tropheus zebra
Pterophyllum scalare
Q
Quahog
R
Rabbitfish Rainbow trout
Rana pipiens Rana temporaria Red-tail catfish Rhlnogobius brunneus Ribbed newt Roach
Rock gunnel Rutilus rutllus
-37-
RTLA Number 2056
2080
2156, 2215 2074, 2116-2122, 2098
2171-2174
2077
2211, 2212
2099
2181
2075
2136
2112 V 2161 2130 2082
2156, 2215
2130
2041
2182
2149-2153 2145, 2146 2047 2047 2111
2135, 2189
2085-2090, 2137-2139
2106
2049, 2059, 2062, 2129, 2154, 2210, 2214, 2216, 2218 2191-2193 2127 2112 2109 2182 2188 2136 2188
-38-
RTLA Number
Sablef ish Salmo gairdneri
Salmo trutta Sandbar shark Sauromalus obesus Sea fan
Sebastes f lavidus Sebastolobus alascanus Sheep shead minnow Shortspine thornyhead Shrimp
Siamese fighting fish Siganus fuscescens Silver shad Soft clam
South African clawed frog
Spiny dogfish
Spot
Spotted gar Squalus acanthias Stizostedion vitreum vitreum Striped mullet Strongylura marina Sydney rock oyster
T
Theragra chalcogramma Three-spot gourami Thrissocles malabarica
Thunnus thynnus Tiger salamander Topminnow
Trichogaster trichopterus Trichiurus lepturus
V
Varanus salvator Vermilion rockfish
W
Walleye
Walleye pollock Whiting
Worm (parasitic)
2179, 2180
2059, 2062, 2129, 2154, 2210, 2214, 2216, 2218 2213, 2217 2110 2190
2094
2177, 2178 2175, 2176 2058
2175, 2176
2099
2134
2106
2160
2091
2096,' 2123-2126
2165
2158
2115
2165
2063
2095 2081
2157, 2183-2187
2101
2143
2142 2128 2060
2145, 2146
2143 2159
2114
2178
2063
2101
2048
2077
-39-
RTLA Number
XYZ
Xenopus laevis Yellowfin sole Yellowtail rockfish Zebraf ish
Zebrasoma f lavescens
2123-2126, 2219
2084
2177
2163
2163
-40-
CONTRIBUTORS
ADACHI, T.
California Koi Farms, Inc.
3360 Gird Road
Fallbrook, California 92028 RTLA 2052
AWAKURA, T.
Laboratory of Fish Pathology Hokkaido Fish Hatchery Nakanoshima, Tohira-ku, Sapporo Hokkaido, Japan RTLA 2215, 2216
BALAZS, G. H.
Hawaii Institute of Marine Biology University of Hawaii at Manoa P. 0. Box 1346, Coconut Island Kaneohe, Hawaii 96744 RTLA 2042, 2097
BALOUET, G.
Laboratoire d’Anatomle Pathologique Gentre Hospitaller et Unlversitalre de Brest B, P. 815
29279 Brest Cddex, France RTLA 2117-2122
BELL, G. R.
Pacific Biological Station Fisheries Research Board of Canada P. 0. Box 100
Nanaimo, B. C. , V9R 5K6, Canada RTLA 2156
BLASIOLA, G. C. , JR.
Hill’s Kordon 2242 Davis Court Ha)n^rard, California 94545 RTLA 2075, 2076, 2189
BOUSTEAD, N.
Fisheries Research Division
Ministry of Agriculture and Fisheries
P. 0. Box 19062
Wellington, New Zealand
RTLA 2062, 2095, 2217, 2218
BUCKE, D.
Ministry of Agriculture, Fisheries and Food
Fish Diseases Laboratory
The Nothe, We5miouth, Dorset DT4 8UB
England
RTLA 2047, 2048
CHING, H. L.
Department of Zoology University of British Columbia 2075 Westbrook Mall Vancouver, B. C., V6T 1W5, Canada RTLA 2084
COHEN, S.
Pathology Department Kaiser Foundation Hospitals 13652 Cantara Street Panorama City, California 91402 RTLA 2065-2068
COLLETTE, B. B.
Division of Fishes National Museum of Natural History Smithsonian Institution Washington, D. C. 20560 RTLA 2136
COOPER, J. E.
Royal College of Surgeons 35-43 Lincoln’s Inn Field London, WC2A 3PN, England RTLA 2208
COSGROVE, G. E.
Zoological Society of San Diego P. 0. Box 551
San Diego, California 92112 RTLA 2161-2164
COUCH, J. A.
Biological Laboratory
U. S. Environmental Protection Agency
Sabine Island
Gulf Breeze, Florida 32561 RTLA 2058, 2071, 2132, 2158, 2159
DANIELS, B.
Automatic Data Processing National Museum of Natural History Smithsonian Institution Washington, D. C. 20560 RTLA 2209
DELANNEY, L. E.
The Jackson Laboratory Bar Harbor, Maine 04609 RTLA 2093
DIAMOND, H.
Graduate School of Oceanography Narragansett Bay Campus University of Rhode Island Kingston, Rhode Island 02881 RTLA 2085-2090, 2137-2139
DOW, R.
Fisheries Research Station Maine Department of Marine Resources West Boothbay Harbor, Maine 04575 RTLA 2091, 2092
ELKAN, E.
Department of Histopathology Mount Vernon Hospital Northwood, Middlesex, HA6 2RN England RTLA 2072
FRYE, F. L.
741 Plum Lane
Davis, California 95616
RTLA 2073
GIBSON, D. I.
Parasitic Worm Section British Museum Cromwell Road London, SW7 5BD, England RTLA 2077
GORMAN, I.
Sharkey - Simpson
1500 - 1502 W. Santa Barbara Ave.
Los Angeles, California 90062 RTLA 2054, 2133
GOUDZWAARD, J.
Kansas Fish and Game Box 88
Valley Falls, Kansas 66088 RTLA 2078
GRIZZLE, J.
Department of Fisheries and Allied Aquacultures Auburn University Auburn, Alabama 36830 RTLA 2166
GRUBER, S. H.
Division of Biology and Living Resources
School of Marine and Atmospheric Science
University of Miami
4600 Rickenbacker Causeway
Miami, Florida 33149
RTLA ?061
HAGGARD, S. S.
Zoology Department University of Maine at Orono Orono, Maine 04469 RTLA 2147, 2148
HARADA, T.
Faculty of Fisheries Hokkaido University Hakodate, Japan RTLA 2099-2101
HARSHBARGER, J. C.
Registry of Tumors in Lower Animals National Museum of Natural History Smithsonian Institution Washington, D. C. 20560 RTLA 2091, 2092
HAUCK, A. K.
Alaska Department of Fish and Game 333 Rasberry Road Anchorage, Alaska 99502 RTLA 2043
HEATH, W. A.
Seakem Oceanography Ltd.
9817 West Saanich Road Sidney, B. C. , V8L 3S1, Canada RTLA 2194-2207
-42-
HELDSTAB, A.
Instltut fur Tierpathologie Universitat Bern LSnggass-Strasse 122 3000 Bern, Switzerland RTLA 2069, 2070
HIGGINS, R. P.
Division of Worms
National Museum of Natural History Smithsonian Institution Washington, D. C. 20560 RTLA 2083
HITACHI, PRINCE MASAHITO Cancer Institute 1-37-1, Kami-Ikebukuro Toshima-ku, Tokyo 170 Japan
RTLA 2106-2116 HOFFMAN, G. L.
Fish Farming Experimental Station Fish and Wildlife Service U. S. Department of the Interior Box 860
Stuttgart, Arkansas 72160 RTLA 2050, 2057
HOOVER, K. L.
Tumor Pathology Branch National Cancer Institute Del Ray Building, Room 406 Bethesda, Maryland 20205 RTLA 2056
HURST, J.
Fisheries Research Station Maine Department of Marine Resources West Boothbay Harbor, Maine 04575 RTLA 2091, 2092
JACOBSON, E.
Health Center Animal Resources Department
J. Hillis Miller Health Center University of Florida P. 0. Box J-6
Gainesville, Florida 32610 RTLA 2130, 2144
jSnisch, W.
Pathologisches Institut der Martln-Luther-Unlversltat Halle-Wittenberg
Leninallee 14, PostchlieBf ach 545 DDR - 402 Halle (Saale)
(German Democratic Republic)
RTLA 2182, 2219
KANDRASHOFF, W.
951 Euclid Avenue
Miami Beach, Florida 33139
RTLA 2080-2082, 2102-2105, 2160, 2167
KHUDOLEY, V. V.
Centre International de Recherche sur le Cancer 150, Cours Albert-Thomas 69372, Lyon Cddex 2, France RTLA ^123-2127
KLEMPAU, A.
Department of Biology University of California, Los Angeles Los Angeles, California 90024 RTLA 2190-2193
KUFEL, J.
Botanical Institute Wroclaw University ul. Kanonla 6/8 50-328 Wroclaw, Poland RTLA 2044-2046
LANGE, C.
Department of Experimental Radiology School of Medicine and Dentistry University of Rochester Rochester, New York 14642 RTLA 2041
LAURENCIN, F. B.
Laboratoire National de Pathologie des Animaux Aquatiques B. P. 337
29273 Brest Cddex, France RTLA 2117-2122
LAURIE, J. S.
Biology Department East Carolina University Station Greenville, North Carolina 27834 RTLA 2064
-43-
MASON, R. W.
Mt. Pleasant Laboratories Department of Agriculture P. 0. Box 46
Launceston South, Tasmania 7250 RTLA 2055
MILLARD, J. L.
San Marcos National Fish Hatchery and Development Center Fish and Wildlife Service U. S. Department of the Interior P. 0. Box 786 San Marcos, Texas 78666 RTLA 2063
MOCCIA, R. D.
Department of Pathology Ontario Veterinary College University of Guelph Guelph, Ontario, NIG 2W1, Canada RTLA 2074, 2213
MONDAY, B. L.
Mt. Pleasant Laboratories Department of Agriculture P. 0. Box 46
Launceston South, Tasmania 7250 RTLA 2059, 2128
MURCHELANO, R. A.
Oxford Laboratory National Marine Fisheries Service U. S. Department of Commerce Oxford, dryland 21654 RTLA 2052
MUZIK, K.
c/o Division of Echinoderms National Museum of Natural History Smithsonian Institution Washington, D. C. 20560 RTLA 2094
NEILAND, K. A.
Division of Game
State of Alaska Department of Fish and Game
1300 College Road Fairbanks, Alaska 99701 RTLA 2098
NORRIS, J. N.
Department of Botany
National Museum of Natural History |
Smithsonian Institution Washington, D. C. 20560 RTLA 2094
OISHI, K.
Faculty of Fisheries il
Hokkaido University Hakodate, Japan RTLA 2099-2101
OTTO, S. V.
Marine Animal Disease Investigations State Laboratory
Maryland Department of Natural Resources: Oxford, Maryland 21654 RTLA 2079
otto,'t. N.
Rangen Research Route One, P. 0. Box 264 Hagermen, Idaho 83332 RTLA 2214
PICKERING, R.
California Koi Farms, Inc.
3360 Gird Road
Fallbrook, California 92028 RTLA 2052
PULLAN, S. G.
Fisheries Laboratory
Ministry of Agriculture and Fisheries P. 0. Box 2298 Wellington, New Zealand RTLA 2053, 2134, 2135
RADHAKRISHNAN, S.
Department of Aquatic Biology and Fisheries
University of Kerala Trivandrum 695007 Kerala State, India RTLA 2140-2143
ROSE, F. L.
Department of Biological Sciences Texas Tech University Box 4149
Lubbock, Texas 79409 RTLA 2060
-44-
SCHMIDT, TH.
Institute of Anatomy Martin-Luther University Halle-Wittenberg German Democratic Republic RTLA 2219
SCHULTZ, R. J.
The Biological Sciences Group The College of Liberal Arts and Sciences
The University of Connecticut Storrs, Connecticut 06268 RTLA 2145, 2146
SLOOFF, W.
Ecotoxicology of Chemicals National Institute for Water Supply P. 0. Box 150
Leidschendam, The Netherlands RTLA 2155, 2188
SMITH, C. E.
Fish Cultural Development Center
Fish and Wildlife Service
U. S. Department of the Interior
4050 Bridger Canyon Road
Bozeman, Montana 59715
RTLA 2050, 2129, 2154, 2210-2212
VERHOEFF-DE FREMERY, R.
Animal Department Hubrecht Laboratory Universiteitscentrum „de Uithof" Utrecht, The Netherlands RTLA 2096, 2131
WARNER, R. W.
Marine Resources Laboratory California Department of Fish and Game 619 Second Street, Room 111 Eureka, California 95501 RTLA 2168-2181
WOLF, H.
Fish Disease Laboratory
California Department of Fish and Game
2111 Nimbus Road
Rancho Cordova, California 95670 RTLA 2051
WOLF, K. E.
National Fish Health Research Lab U. S. Department of the Interior Route 3, Box 50
Kearneysville, West Virginia 25430 RTLA 2049
WOLF, P. H.
Scientific Section
New South Wales State Fisheries
P. 0. Box N211, Grosvenor Street
Sydney, 2000, Australia
RTLA 2157, 2183-2187
WOODHEAD, A. D.
Department of Biology Brookhaven National Laboratory Associated Universities, Inc.
Upton, Long Island, New York 11973 RTLA ^49-2153, 2165
YAMAMOTO, S.
Faculty of Fisheries Hokkaido University Hakodate, Japan RTLA 2099-2101
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TEAR OUT ACCESSION SHEET
PLEASE SUBMIT TO:
Dr. John C, Harshbarger Registry of Tumors in Lower Animals National Museum of Natural History Room W216-A
Smithsonian Institution Washington, D.C., 20560, USA
COMMON NAME _ _ _ FAMILY _
PHYLUM _ GENUS _ _
CLASS _ _ _ SPECIES _ _
ORDER _ _
CATEGORY: NEOPLASM _ _ INFLAMMATION _ _ INFECTION _ PAPAS ITIC _ TOXIC
DEVELOPMENTAL _ TRAUMATIC _ NORMAL _ _ OTHER _
CONTRIBUTOR (NAME & ADDRESS); COLLECTOR (NAME & ADDRESS):
DATE RECD. _
CONTRIBUTOR'S NO, RTLA NO. _______
USNM NO, _____
NIH HISTOPATH NO.
ITEMS SUBMITTED (QUANTITY):
GROSS MATERIAL _ PHOTOGRAPHS _
SLIDES _ _ _ REPRINTS _
BLOCKS _ OTHER _
ORIGIN OF ANIMAL: MARINE _ FRESHWATER _ ESTAURINE _ TERRESTRIAL
WHERE COLLECTED _
date collected _______ SEX _ AGE _ STAGE OF LIFE CYCLE
HOW KILLED _ _ FIXATION _
GROSS DESCRIPTION _
MICROSCOPE DX
COMMENTS (e.go, possible exposure to chemical pollutants or infectious agents, in¬ cidence and duration of this condition in the population, etc.)
(Please use reverse side, if more space is needed)
ACTIVITIES REPORT
REGISTRY OF TUMORS IN LOWER ANIMALS: 1980 SUPPLEMENT JOHN C. HARSHBARGER, DIRECTOR
PREPARED FOR DISTRIBUTION BY:
REGISTRY OF TUMORS IN LOWER ANIMALS ■ NATIONAL MUSEUM OF NATURAL HISTORY ROOM W216-A
SMITHSONIAN INSTITUTION WASHINGTON, D. C. 20560
NIH Contract No. NOl CP 33874 (Contractor: Smithsonian Institution)
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''1
CONTENTS
OVERVIEW . . . 1
REFERENCE LIBRARY . 3
PAPERS SINCE 1979 . 3
SELECTED ACTIVITIES IN 1980 . 4
PERSONNEL . 6
ACCESSIONS . 7
INDEX OF NEOPLASTIC AND HYPERPLASTIC LESIONS -
ANIMAL GROUP - AND RTLA NUMBER . 24
PHYLOGENETIC INDEX . 26
INDEX OF SPECIMENS BY SCIENTIFIC AND
COMMON NAMES . 29
CONTRIBUTORS . 34
TEAR OUT ACCESSION SHEET . Last page
Smithsonian Institution Washington, D. C. 1981
OVERVIEW
The Registry of Tumors in Lower Animals (RTLA) facilitates the study of neoplasms and related disorders in invertebrate and poikilothermic vertebrate animals by serving as a specimen deposi¬ tory, a diagnostic center, an information center and a research group .
Among new accessions, were two amine precursor uptake and decarboxylase (APUD) neoplasms: a carcinoid tumor from the hindgut of an indigo snake (RTLA 2335; M. D. Lagios) and a chemodectoma in a gaboon viper (RTLA 2317; A. Heldstab) . The central nervous sys¬ tem was represented by an induced meningotheliomatous meningioma in a brook trout (RTLA 2361; L. Crutcher).
Other neoplasms of neural crest origin included a neurilemmal sarcoma in a brook trout (RTLA 2224; J. E. Carlisle) and neurilemmoma in a goldfish (RTLA 2244; H. Wolf), in a dab (RTLA 2259; D. Bucke) and three lesions in a schoolmaster (RTLA 2289; W. Kandrashoff ) ,
The schoolmaster also had a fourth histopathologically similar le¬ sion which contained reflective platelets, presumably of guanine, and was diagnosed as an iridophoroma. Pigment cell tumors also in¬ cluded an invasive chromatophoroma in a rainbow boa (RTLA 2249; J.
P. Sundberg) , melanophoric neurilemmoma in two croaker species and a grunt (RTLA 2297-9; L. T. Findley and A. J. Mearns) , an Invasive melanophoroma in a southern platyfish (RTLA 2358; N. Herwig) and an Iridophoroma in a largemouth bass (RTLA 2349; C. E. Smith). Re¬ cently, J. Matsumoto, T. Ishikawa, Prince Masahito and S. Takayama reported in the Proceedings of The Eleventh International S3nnposium of The Princess Takamatsu Cancer Research Fund: Phyletic Approaches to Cancer (Nov. 1981 publication expected) that individual cells from goldfish and sciaenid fish pigment cell tumors cultured in vitro simultaneously contained organelles for producing more than one pigment and recommended designating multipigmented neoplasms as chromatobias toma. Based on this work, on observations of neoplasms resembling pigmented neurilemmoma (e.g. , the school¬ master, croaker and grunt already mentioned), and one reported ab¬ sence of the characteristic Schwann cell basement membrane in goldfish neurilemmoma, perhaps fish neoplasms commonly diagnosed as "neurilemmoma" on morphologic grounds actually originate from a neural crest stem cell precursor of the chromatoblast.
Connective tissue neoplasms included a lepidocytoma (scale¬ forming fibroma) in the skin of an Atlantic salmon (RTLA 2260; D. Bucke), a subcutaneous myxoma in an ide (RTLA 2277; S. Bogovskl) , a subcutaneous fibroma in a brook trout (RTLA 2302; A. George), a subcutaneous fibrosarcoma in a coho salmon (RTLA 2333; J. Hnath) , a cardiac fibrosarcoma in a water monitor lizard (RTLA 2347; P.
Zwart) and a lipoma in an Atlantic bonlto (RTLA 2359; W. Kandrashoff) and a diamondback water snake (RTLA 2338; R. Lawson).
-2-
Endemic papilloma were accessioned from two populations: oral prickle cell papilloma (RTLA 2222; J. Grizzle) which are highly pre¬ valent in black bullhead inhabiting a sewage treatment plant’s oxi¬ dation pond; and seasonal (summer regression) rock oyster mantle papilloma (RTLA 2329-32; P. H. Wolf) from non- industrial estuaries of southeast Australia.
Hepatocellular neoplasms occurred spontaneously in Atlantic tomcod from the Hudson River (RTLA 2252-5; C. E. Smith), one of which (RTLA 2255) was a hepatopancreatocarcinoma; in sauger and walleye from a lake partially filled in with copper mine tailings (RTLA 2257; J. J. Black) and in bream (RTLA 2278, 2280, 2282, 2284; W. Slooff) from rivers in The Netherlands. Hepatocarcinoma were Induced in an Amazon molly (RTLA 2271; A. D. Woodhead) and rivulus (RTLA 2319, 2348; M. P. Chasar) .
Also induced was an intestinal adenomatous polyp in a rain¬ bow trout (RTLA 2370; I. Kimura) . Other glandular tumors in¬ cluded a metastatic mucinous adenocarcinoma in a timor python (RTLA 2293; E. Jacobson) and a mucoid adenocarcinoma of un¬ determined visceral origin in a Burmese python (RTLA 2296; S.
Emanuel son) .
Hematopoietic neoplasms included the first unequivocal granulocytic neoplasm in an amphibian, a granulocytic leukemia in a clawed frog (RTLA 2318; K. L. Hoover and M. Dworkin) , and lymphoma in a plated lizard (RTLA 2316; A. Heldstab) , a rainbow
trout (RTLA 2251; C. E. Smith), an Atlantic herring (RTLA 2258;
D. Bucke) , an eastern kingsnake (RTLA 2240; E. Jacobson) and a northern pike (RTLA 2276; S. Bogovski) .
Reproductive system neoplasms were: a seminoma in a zebra danio (RTLA 2220; J. B. Nold) , a sertoli cell tumor in an Egyptian
cobra (RTLA 2336; F. L. Frye) and a granulosa cell tumor in a rain¬
bow trout (RTLA 2371; I. Kimura).
Mesothelioma occurred in two chlnook salmon (RTLA 2238; C. E. Smith and RTLA 2241; G. L. Hendrickson).
Leiomyoma were seen in a sauger (RTLA 2257; J. J. Black) and a brown trout (RTLA 2301; B. L. Munday) . A leiomyoblastoma was seen in a Texas indigo snake (RTLA 2264; F. L. Frye).
Circulatory system neoplasms included a hemangioendothelio- sarcoma in a rainbow trout (RTLA 2239; C. E. Smith), a hemangio¬ endothelioma in a flounder (RTLA 2315; S. Bogovski) and a hemangioma in an oscar (RTLA 2247; C. A. Gleiser and N. Herwlg) .
Hypernephroma occurred in an Asiatic cobra (RTLA 2334; E. Jacobson and L. Kramer) and nephroblastoma occurred in rainbow trout (RTLA 2350-1; C. E. Smith).
-3-
Thyroid hyperplasia/neoplasia was seen in a roach (RTLA 2281; W. Slooff) and Amazon mollies (RTLA 2271, 2328; A. D. Woodhead) . The spleens of the Amazon mollies were substantially replaced by well-differentiated thyroid follicles raising the question of whether this represents ectopic thyroid, which is known to occur in various organs Including spleen, or a metastasis.
A series of non-neoplastic developmental anomalies in sea lamprey (RTLA 2227-35; G. W. Piavis) originated from northeast Michigan. Coincidentally an earlier series of teratoid anomalies in lake trout were also from Michigan (RTLA 1961-80; J. Hnath) . Another dysmorphogenic anomaly occurred in the anterior ventral trunk region between the pectoral fins of a brown trout (RTLA 2300; B. L. Munday) as if an attempt at Siamese twinning.
Other non-neoplastic lesions included: an amebic (X-cell) pseudotumor in an Atlantic cod (RTLA 2290; C. Morrison) (for evidence that the X-cell is a unicellular organism see Dawe, C. J. Polyoma tumor in mice and X-cell lesions in fish viewed through microscope and telescope. The Proceedings of The Eleventh In¬ ternational Symposium of The Princess Takamatsu Cancer Research Fund; Phyletic Approaches to Cancer; Nov. 1981 publication ex¬ pected); an adenomatous hyperplasia of the epithalamus of a giant tortoise (RTLA 2248; R. Mueller) described in the paper cited in the "Accessions’* section of this report; prokaryote infections in razor clams (RTLA 2303-14; S. V. Otto); lymphocystls in a fat sleeper (RTLA 2288; F, J. Schwartz and R. Mdrquez) and adenofi- brosis in bream (RTLA 2283-4; W. Slooff).
Computerized retrieval of specimen information is possible by pertinent key words. Utilizing this system, a complete index of all neoplasms through 1980, based on system of origin, will be published in November 1981. See reference, "Harshbarger , Charles and Spero," in the section, "Papers Since 1979," below.
REFERENCE LIBRARY
The comprehensive computerized library on neoplasms and related disorders in ecto thermic animals was enlarged and consolidated.
PAPERS SINCE 1979
Harshbarger, J. C. 1980. Neoplasms in zoo poikllotherms emphasizing cases in the Registry of Tumors in Lower Animals. In: Symposia of the National Zoological Park: The Comparative Pathology of Zoo Animals, R. J. Montali and G. Migaki (eds.), pp. 585-591, Smith¬ sonian Institution Press: Washington, D. C.
-4-
Harshbarger, J. C. , E. R. Jacobson, C. E, Smith, and J. A. Couch. 1980. Hematopoietic neoplasms in invertebrates and cold-blooded vertebrates. In: Advances in Comparative Leukemia Research, D.
Yohn, B. Lapin and J. Blakeslee (eds.), pp. 223-225, Elsevier North Holland: New York.
DeLanney, L. , S. C. Chang, J. Harshbarger, and C. Dawe. 1980. Mast cell tumors in the caudate amphibian, Amby stoma mexicanum. In: Advances in Comparative Leukemia Research, D. Yohn, B. Lapin and J. Blakeslee (eds.), pp, 221-222, Elsevier North Holland: New York.
Sindermann, C. J. , R. B. Bang, N. 0. Christensen, V. Dethlefsen,
J. C. Harshbarger, J. R. Mitchell, and M. F. Mulcahy. 1980. The role and value of pathobiology in pollution effects monitoring programs. Rapp. P.-v. Reun. Cons, int. Explor. Mer, 179 : 135-151.
Black, J. J. , J. Harshbarger, and R. F. Zeigel. 1981. Tumors in fish from a copper contaminated lake. Proc. Am. Assoc. Cancer Res, Am. Soc. Clin. Oncol., April 30-May 2, 1981, Washington, D. C., Vol.
22, p. 134. (abstr.).
Chang, S. C. , J. C. Harshbarger, and S. V. Otto, (in press). Status of cytoplasmic prokaryote infections and neoplasms in bivalve mollusks. Proceedings of the Sixth FDA Science Symposium: Aqua¬ culture — Public Health, Regulatory, and Management Aspects, February 12-14, 1980, New Orleans, Louisiana.
Hoover, K. L. , J. C. Harshbarger, C. W. Lee, W. Banfield, and S, C. Chang, (in press). Intranuclear inclusion bodies within neurons of spinal and cranial ganglia in three cyprinodont species. Cell Tissue Res.
Harshbarger, J. C. (in press). Closing remarks. Proceedings of The Eleventh International S3nnposium of The Princess Takamatsu Cancer Research Fund: Phyletlc Approaches to Cancer, November 11-13, 1980, Tokyo, Japan.
Harshbarger, J. C. , A. M. Charles, and P. M. Spero. (in press). Col¬ lection and analysis of neoplasms in sub-homeothermic animals from a phyletlc point of view. Proceedings of The Eleventh International Symposium of The Princess Takamatsu Cancer Research Fund: Phyletlc Approaches to Cancer, November 11-13, 1980, Tokyo, Japan.
SELECTED ACTIVITIES IN 1980
A. Research activities :
1. Studied, diagnosed and described for the files approximately 160 cases of diseases in cold-blooded vertebrates and in¬ vertebrates.
-5-
2. Collaborated with Sara V. Otto (Maryland Department of Natural Resources, Oxford, Md.) and Sing C. Chang on the incidence, distribution, cellular structure and fine structure of chlamy¬ dia, rickettsia and mycoplasma parasites in bivalve mollusks.
3. Collaborated with Peter H. Wolf (New South Wales State Fisheries, Sydney, Australia) and Sing C. Chang on the fine structure of papillary epitheliomas of the mantle in the Sydney rock oyster, Crassostrea commerclalls .
4. Collaborated with John J. Black and Robert F. Zeigel on hepatocellular carcinoma and other lesions in sauger and walleye from copper polluted Torch Lake, Michigan.
B. Other activities;
1. Member of the World Committee of the International Associ¬ ation for Comparative Research on Leukemia and Related Diseases.
2. Member of the Interagency Collaborative Group on Environmental Carcinogenesis.
3. Member of the Permanent Program Committee and Chairman of the Admissions Committee of the Society for Invertebrate Pathology.
4. Member of the Organizing Committee of The Eleventh International Symposium of The Princess Takamatsu Cancer Research Fund: Phy- letic Approaches to Cancer.
5. Member of the Editorial Board of the "Journal of Fish Diseases".
6. President of the Washington, D. C. Chapter of Sigma Xi, The Scientific Research Society.
7. Attended the Foundation for Advanced Education in the Sciences’ course, "Malformation in developmental biology," National Institutes of Health, Bethesda, Md. , Spring 1980.
C. Meetings;
1. Presented with Sing C. Chang, "Status of cytoplasmic pro¬ karyote infections and neoplasms in bivalve mollusks," at the Sixth FDA Science Symposium: Aquaculture — Public Health, Regulatory, and Management Aspects, February 12-14, 1980, New Orleans, Louisiana.
2. Participated in a molluscan workshop at the Xlllth Annual Meeting of the Society for Invertebrate Pathology, July 27- August 1, 1980, Seattle, Washington.
-6-
3. Presented, "Collection and analysis of neoplasms in sub- homeothermic animals from a phyletic point of view" and "Closing remarks," at The Eleventh International Symposium of The Princess Takamatsu Cancer Research Fund: Phyletic Approaches to Cancer, November 11-13, 1980, Tokyo, Japan.
|
PERSONNEL |
|
|
Project Officer: |
Dr. Clyde J. Dawe, Head, Comparative Oncology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Md. , 20205 |
|
Principal Investigator: |
Dr. Clyde F. E. Roper, Chairman, Department of Invertebrate Zoology, National Museum of Natural History, Smithsonian Institution, Washington, D. C., 20560 |
Registry Staff
|
Director: |
John C. Harshbarger, Ph.D. |
|
Microbiologist/ Electron Microscoplst : |
Sing Chen Chang, Ph.D. |
|
Registrar: |
Phyllis M. Spero, B. S. |
|
His to technologic Specialist: |
Linda J. Cullen, B. A. |
|
Research Assistant: |
Ann M. Charles, B. A. |
|
Research Assistant: |
Marilyn S. Slatick, B. S. |
-7-
ACCESSIONS
RTLA 2220. Zebra danio, Brachydanio rerio
Material: One microslide; 3 color transparencies
Habitat: Home aquarium; Silver Spring, Maryland
Diagnosis: Well-differentiated seminoma Submitter: J. B. Nold
RTLA 2221. Dolphin (fish), Coryphaena hippurus
Material: Piece of muscle tissue with nodular growth
Habitat: Gulf Stream, Off Miami Beach, Florida
Diagnosis: Muscle atrophy, necrosis and chronic inflammation probably due to traumatic Injury Submitter: W. Kandrashoff
RTLA 2222. Black bullhead, Ictalurus melas
Material: Three microslides; 3 color transparencies;
5 electron micrographs
Habitat: Final oxidation pond of sewage treatment plant,
Tuskegee, Alabama
Diagnosis: Papilloma with virus-like particles
Submitter: J. Grizzle
Reprint: Grizzle, J. M. , T. E. Schwedler, and A. L. Scott.
1981. Papillomas of black bullheads, Ictalurus melas (Raf inesque) , living in a chlorinated sewage pond. J. Fish Dis. , ^:345-351.
RTLA 2223. Blue shrimp, Penaeus stylirostris
Material: Thirteen microslides; 5 black and white photographs
Habitat: Environmental Research Laboratory, University of
Arizona, Tucson, Arizona
Diagnosis: Multifocal nodule formation possibly in response to injury of blood vessel walls Submitter: D. Llghtner
RTLA 2224. Brook (speckled) trout, Salvelinus fontinalls Material: Twelve microslides
Habitat: Shingle Shanty Stream, Adirondack Mountains, New York
Diagnosis: Neurilemmal sarcoma Submitter: J. E. Carlisle
RTLA 2225. Axolotl, Amby stoma mexicanum
Material: Piece of liver and pancreatic tissue
Diagnosis: "Normal"
Submitter: R. Verhoeff-de Fremery
RTLA 2226. Clawed frog, Xenopus sp.
Material: Greatly enlarged spleen
Diagnosis: Splenitis with bacteremia
Submitter: R. Verhoeff-de Fremery
-8-
RTLA 2121 , Sea lamprey, Petromyzon marinus
|
Material: |
Six microslides, 5 of which are controls; 3 color transparencies; 2 reprints |
|
Habitat: Diagnosis: Submitter: Reprint : |
Ocqueoc River, Presque Isle County, Michigan Ruptured ectopic notochord with inflammation G. W. Piavis Piavis, G. W. , T. Beckerman and J. H. Howell. 1979. Teratoid lesions and other developmental anomalies in the sea lamprey, Petromyzon marinus L. J. Fish Dis., 2:353-366. Piavis, G. W., T. Beckerman and J. H. Howell. 1979. Teratoid lesions in the sea lamprey, Petromyzon marinus. Anat. Rec. , 193:654. |
RTLA 2228, 2229. Sea lamprey, Petromyzon marinus
|
Material: |
One microslide (controls: RTLA 2227) and 3 color |
|
Habitat: Diagnosis: Submitter: Reprint : |
transparencies per case Ocqueoc River, Presque Isle County, Michigan Teratoid anomaly G. W. Piavis (see RTLA 2227) |
RTLA 2230. Sea lamprey, Petromyzon marinus
|
Material: |
One microslide (controls: RTLA 2227); 3 color trans |
|
Habitat: Diagnosis: Submitter: Reprint : |
parencies Ocqueoc River, Presque Isle County, Michigan Papillary epidermoid cyst G. W. Piavis (see RTLA 2227) |
RTLA 2331, 2232. Sea lamprey, Petromyzon marinus
|
Material: |
One microslide and 1 color transparency (RTLA 2231) 2 microslides (RTLA 2232); (controls: RTLA 2227) |
|
Habitat : Diagnosis: Submitter: Reprint : |
Ocqueoc River, Presque Isle County, Michigan Teratoid anomaly G. W. Piavis (see RTLA 2227) |
RTLA 2233. Sea lamprey, Petromyzon marinus
|
Material: Habitat: Diagnosis: Submitter: Reprint : |
One microslide (controls: RTLA 2227) Ocqueoc River, Presque Isle County, Michigan Teratoid anomaly G. W. Piavis (see RTLA 2227) |
RTLA 2234. Sea lamprey, Petromyzon marinus
|
Material: Habitat : Diagnosis: Submitter: Reprint : |
Two microslides (controls: RTLA 2227) Ocqueoc River, Presque Isle County, Michigan Ectopic hematopoietic myeloid tissue G. W. Piavis (see RTLA 2227) |
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RTLA 2235. Sea lamprey, Petromyzon marlnus
Material: One microslide (controls: RTLA 2227)
Habitat: Ocqueoc River, Presque Isle County, Michigan
Diagnosis: Teratoid anomaly Submitter: G. W. Piavis Reprint: (see RTLA 2227)
RTLA 2236. Ocean pout, Macrozoarces amerlcanus
Material:
Habitat : Diagnosis:
Submitter:
Section of body wall with raised lesion; piece of tissue excised from body wall containing portion of lesion
Offshore: Quiogue, New York
Myopathic microsporidan (Pleistophora macrozoarcldis) infection, resulting in hypertrophy and destruction of skeletal muscle bundles and exuberant granulomatous reaction E. I. Coher
RTLA 2237. Pinfish, Lagodon rhomboides
Material: Head; a section of body with pectoral and pelvic
fins; piece of body wall with nodular growth Habitat: North Biscayne Bay, Miami, Florida
Diagnosis: Granulation tissue containing a trematode
Submitter: W. Kandrashoff
RTLA 2238. Chinook (king) salmon, Oncorhynchus tshawytscha
Material:
Habitat : Diagnosis : Submitter:
A portion of a growth which had disintegrated into tissue bits with the exception of outer wall which had remained intact
Dworshak National Fish Hatchery, Idaho Possible mesothelioma C. E. Smith
RTLA 2239. Rainbow trout, Salmo gairdneri
Material: Two adjacent pieces of growth near thymus; 2 microslides
Habitat: Yellowstone Trout Ranch, Emigrant, Montana
Diagnosis : Hemangioendotheliosarcoma Submitter: C. E. Smith
RTLA 2240. Eastern king snake, Lampropeltis getulus getulus Material: Five microslides; 1 smear; pathology report
Diagnosis: Malignant lymphoma — poorly-differentiated l5nnphocytic type
Submitter: E. R. Jacobson
RTLA 2241. Chinook (king) salmon, Oncorhynchus tshawytscha Material: An abdominal growth
Habitat: Klamath River, Del Norte County, California
Diagnosis: Mesothelioma — focal mixed mesothelial type Submitter: G. L. Hendrickson
-10-
RTLA 2242, 2243, Material:
Habitat :
Diagnosis: Submitter: Reprint :
Snail, Blomphalarla glabrata Finger-like growths from digestive gland; 2 photo¬ micrographs of crystalline inclusions in fresh squashes of similar tumors from other glabrata specimens; reprint
Laboratory; Biomedical Research Institute, Rockville,
Maryland
Cyst
J. T. Sullivan
Richards, C. S. 1980. Abnormal growths from the digestive gland of Blomphalarla glabrata. J. Invertebr. Pathol., 3^:318-319.
RTLA 2244. Goldfish, Carassius auratus Material: Tissue bits of a growth
Habitat: Backyard pond, Sacramento,
Diagnosis: Neurilemmoma (Schwannoma) Submitter: H. Wolf
California
RTLA 2245, Rainbow trout, Salmo gairdneri
Material: Microslide of a transverse tissue section through
a pop-eyed animal (at the plane of the eyes) experi¬ mentally exposed to Phosflex 31P for 96 hours; also, brain was extruded through skull Habitat: Columbia National Fishery Research Laboratory,
Columbia, Missouri
Diagnosis: Exopthalmia from post orbital edema
Submitter: L. Crutcher
RTLA 2246. Lemon shark, Negaprion brevirostris
Material: Whole animal; 8 color transparencies
Habitat: Lower Matecumbe Key, Florida
Diagnosis: "Normal"
Submitter: S. H. Gruber
RTLA 2247. Oscar Material:
Habitat :
Diagnosis:
Submitter:
, Astronotus ocellatus
Two mlcroslldes; reports: necropsy protocol and histo¬ pathologic examination
Experimental animal; Houston Zoological Gardens and Aquarium, Houston, Texas Hemang ioma ( 1 owe r jaw)
C. A. Gleiser and N. Herwig
RTLA 2248. Giant tortoise, Testudo glgantea
Material: Four microslides; 2 color transparencies; reprint
Habitat: Basel Zoo, Basel, Switzerland
Diagnosis: Adenomatous hyperplasia of epithalamus Submitter: R. Mueller
Reprint: Fatzer, R. , R. Muller, and R. Fankhauser. 1974.
Hyperplasie der epithalamischen Formationen bei einer Seychellen-Rlesenschildkrote. Schweiz. Arch. Tierheilk. 116:225-229.
-11-
RTLA 2249. Rainbow boa, Epicrates cenchrla maurus
|
Material: Habitat: Diagnosis: Submitter: |
Two microslides; pathology report Pet; St. Thomas, Virgin Islands Invasive chromatophoroma J. P. Sundberg |
RTLA 2250. Bloodworm, Glycera dibranchiata
|
Material: |
Pharynx with large inflamed lesion (animal experi¬ mentally exposed to hexachlorobenzene) |
|
Habitat: |
Laboratory; Sloan-Kettering Institute for Cancer Research, Rye, New York |
|
Diagnosis: |
Generalized metazoan (probably trematode miricidia) infestation and acute focal Inflammation to a nec¬ |
|
Submitter: |
rotizing bacterial infection in the pharynx R. S. Anderson |
RTLA 2251. Rainbow trout, Salmo gairdneri
|
Material: |
Th3mius, 2 pieces of liver, heart, gastrointestinal tract, ovary, 2 pieces of kidney, gill, spleen, and anterior kidney; 13 microslides |
|
Habitat: Diagnosis: |
Montana State Fish Hatchery, Arlee, Montana Malignant lymphoma — diffuse, moderate to well- differentiated type |
|
Submitter: |
C . E . Smith |
|
RTLA 2252-2255. Material: |
Atlantic tomcod, Microgadus tomcod Liver tissue and 3 mlcroslldes each (RTLA 2252 and RTLA 2253); liver tissue and 2 mlcroslldes (RTLA 2254); tissue and 3 mlcroslldes (RTLA 2255) |
|
Habitat: Diagnosis: |
Hudson River, New York Hepatocellular carcinoma (RTLA 2252-RTLA 2254) ; hepatopancreatocarclnoma (RTLA 2255) |
|
Submitter: |
C. E. Smith |
RTLA 2256. Rainbow trout, Salmo gairdneri
|
Material: Diagnosis: |
One microslide Possible autoimmune disease, thick tubular and glomerular capsules, paratubular giant cells, eosinophilic globular material |
|
Submitter: |
C. E. Smith |
RTLA 2257. Sauger, Stizostedion canadense
Material: Nine microslides; 1 color transparency; 4 black
|
Habitat: Diagnosis: |
and white photographs; 8 electron micrographs Torch Lake, Michigan Well-differentiated hepatocellular carcinoma; leiomyoma; crystal inclusions in abdominal neuro¬ secretory cells; mesenteric lymphangioma versus m5rxoma versus mesothelioma |
|
Submitter: |
J. J. Black |
-12-
RTLA 2258. Atlantic herring, Clupea harengus harengus Material: Two microslides
Habitat: Off West coast of England
Diagnosis: Sarcoma, possibly hematopoietic
Submitter: D. Bucke
RTLA 2259. Dab, Material: Habitat : Diagnosis: Submitter:
Limanda limanda
One microslide
Southwest coast of England
Neurilemmoma
D. Bucke
RTLA 2260, 2261. Material : Habitat : Diagnosis :
Submitter:
Atlantic salmon, Salmo salar One microslide each River in Southwest England
Well-differentiated lepidocytoma (RTLA 2260); epi¬ dermal hyperplasia in response to probable parasite (RTLA 2261)
D. Bucke
RTLA
2262. Rainbow trout, Salmo galrdnerl Material: One microslide
Habitat: Rainbow trout farm sited on river water
or Wales
Diagnosis: Proliferative kidney disease associated
protozoan
Submitter: D. Bucke
— England with a
RTLA 2263. Angelfish, Pterophyllum scalare
Material: One microslide; 1 black and white photograph
Diagnosis: Inflammation and reactive hyperplasia with bone
and tooth formation Submitter: G. Migaki
RTLA 2264. Texas indigo snake, Drymarchon corals erebennus Material: Five microslides
Diagnosis: Leiomyob la stoma Submitter: F. L. Frye
RTLA 2265. Bloodworm, Glycera dlbranchlata
Material: Posterior half of worm with growth (animal experi¬
mentally exposed to pentachlorophenol)
Habitat: Laboratory; Sloan-Kettering Institute for Cancer
Research, Rye, New York
Diagnosis: Injury-related ulceration and muscle atrophy
Submitter: R. S. Anderson
RTLA 2266. American oyster, Crassostrea vlrglnica Material: Gill lesions
Habitat: Cheseapeake Bay/Choptank River; Cherry Tree Bar
Diagnosis: Xenomas due to ciliated thlgmotrlchs Submitter: S. V. Otto
-13-
RTLA 2267. Quahog, Mercenaria mercenarla Material: Eighty-four whole animals
|
Habitat: Diagnosis : |
Robin’s Marsh; Turpin's Rock; Chincoteague Bay Chlamydia in digestive diverticula; rickettsia in gills |
|
Submitter : |
J. C. Harshbarger, S. C. Chang and S. V. Otto |
RTLA 2268. Burmese python. Python molorus
|
Material: |
Piece of mesentery with multiple embedded lesions; 3 microslides; 1 paraffin block; necropsy report |
|
Habitat: Diagnosis: Submitter: |
Probably pet; Hartford, Connecticut Hemolymph nodes versus lipid depleted fat nodes R. Chiodini |
RTLA 2269. Skate, Raja clavata
|
Material: |
Stomach, intestine, spleen, pancreas; 1 black and |
|
Habitat: Diagnosis : Submitter: |
white photograph; 1 drawing Skagerrak Sea, Sweden Bland ischemic infarct R. Fange |
|
RTLA 2270, 2271. Material: |
Amazon molly, Poecllia formosa Two whole animals each (experimentally treated with anthracene) |
|
Habitat : |
Laboratory; Brookhaven National Laboratory, Upton, New York |
|
Diagnosis: |
RTLA 2270 - thyroid normal; spleen and liver missing; RTLA 2271 - hepatocarcinoma; goiter; spleen 99% replaced by ectopic (neoplastic ?) thyroid |
|
Submitter: |
A. D. Woodhead |
RTLA 2272. Bloodworm, Glycera dibranchiata
|
Material : |
Swollen pharynx with red nodules (animal experi¬ mentally exposed to hexachlorobenzene) |
|
Habitat : |
Laboratory; Sloan-Kettering Institute for Cancer Research, Rye, New York |
|
Diagnosis: |
Nodular distensions of pharynx to accommodate a large ingested nematode |
|
Submitter: |
R. S. Anderson |
RTLA 2273. Bloodworm, Glycera dibranchiata
|
Material: |
Middle fragment of a control worm with a dorsal lesion disrupting segmentation |
|
Habitat: |
Laboratory; Sloan-Kettering Institute for Cancer |
|
Diagnosis: |
Research, Rye, New York Dorsal ulceration with much of dorsal muscle replaced by aseptic scar tissue probably due to injury |
|
Submitter : |
R. S. Anderson |
-14-
RTLA 2274. Bloodworm, Glycera dlbranchlata
|
Material: |
Anterior end of a worm with a bllster-llke lesion on the dorsal surface |
|
Habitat : |
Laboratory; Sloan-Ketterlng Institute for Cancer Research, Rye, New York |
|
Diagnosis; Submitter: |
Muscle erosion. Inflammation and scarring R. S. Anderson |
RTLA 2275. Bloodworm, Glycera dlbranchlata
|
Material: |
Anterior part of a worm with small lesion on |
|
Habitat: |
pharynx Laboratory; Sloan-Ketterlng Institute for Cancer Research, Rye, New York |
|
Diagnosis: Submitter : |
Muscle destruction and replacement by scar tissue R. S. Anderson |
RTLA 2276. Northern pike, Esox Indus
Material; One piece of tissue; 1 mlcrosllde
|
Habitat: Diagnosis: Submitter: |
Southern part of Finnish Gulf Lymphoma S. Bogovskl |
|
RTLA 2277. Ide, Material: |
Leuclscus Idus One piece of tissue from subcutaneous head lesion; 1 mlcrosllde |
|
Habitat: Diagnosis : Submitter: |
In the estuary of the River Kasarl, USSR Myxoma S. Bogovskl |
RTLA 2278. Bream, Abramls brama
|
Material: Habitat : Diagnosis; Submitter: |
Oval, nodular piece of liver Waal River, The Netherlands Hepatocellular carcinoma — moderately well-differentiated W. Slooff |
RTLA 2279. White (silver) bream, Bllcca bjoerkna
|
Material: Habitat: Diagnosis: Submitter: |
An elongate wedge of liver tissue Loblth River, The Netherlands Immense diffuse macrophage response W. Slooff |
RTLA 2280. Bream, Abramls brama
Material: Oval, nodular piece of tissue
Habitat: Lek River, The Netherlands
Diagnosis: Cholanglocarclnoma
Submitter: W. Slooff
RTLA 2281. Roach, Rutllus rutllus
|
Material: Habitat: Diagnosis; |
A piece of gill tissue with lumps at base of filaments Lek River, The Netherlands Thyroid adenoma with fetal, colloid, and Hurthle cell components |
|
Submitter; |
W. Slooff |
-15-
RTLA 2282. Bream, Abramls brama
Material: Heart-shaped piece of tissue with an orangish outer layer
Habitat: Lek River, The Netherlands
Diagnosis: Hepatocellular carcinoma — moderately differentiated Submitter: W. Slooff
RTLA 2283. Bream, Abramis brama
Material: An amorphous piece of tissue with lesions embedded in
surface
Habitat: Lek River, The Netherlands
Diagnosis: Adenof ibrosis (cholangiof ibrosis)
Submitter: W. Slooff
RTLA 2284. Bream, Abramla brama
Material: Wedge of tissue with spots or threads; 1 paraffin block
Habitat: Lek River, The Netherlands
Diagnosis: Adenof ibrosis; hepatocarcinoma Submitter: W. Slooff
RTLA 2285. Bream, Abramis brama
Material: Heart with protrusion
Habitat: Lek River, The Netherlands
Diagnosis: Perforated heart — some type of injury and repair Submitter: W. Slooff
RTLA 2286. Ocean sunfish. Mo la mola Material: Two pieces of liver
Habitat: Neuse River between Adams Creek and Clubfoot Creek,
North Carolina
Diagnosis: Reactive fibrosis in response to worm parasites Submitter: F. J. Schwartz
RTLA
2287. White sucker, Catostomus commersoni
Material:
Habitat:
Diagnosis:
Submitter:
Whole specimen with cyst-like lesion on right cheek, cyst-like lesion on left comer of mouth and two nodular lesions on lower jaw; misaligned spine Lung Creek on Queens Highway 2 in Queen's County, New Brunswick, Canada Protozoan infection; scoliosis F. J. Schwartz
RTLA 2288. Fat sleeper, Dormitator maculatus
Material: Whole animal with rugose growth on right side
Habitat: Rain pond; Isleta Pdrez, Tampico, Tamauli pas., Mdxico
Diagnosis: Lymphocystis
Submitter: F, J. Schwartz and R. Marquez
RTLA 2289. Schoolmaster, Lut janus apodus
Material: Viscera: two pieces of skin and attached muscle,
each with a growth
Habitat: South of Bear Cut on the reefs; fairly close to an
outfall on Virginia Key, Florida Diagnosis: Neurilemmoma; iridophoroma Submitter: W. Kandrashoff
-16-
RTLA 2290. Atlantic cod, Gadus morhua Material: One microslide
Habitat: Probably Halifax Harbour, Halifax, Nova Scotia, Canada
Diagnosis: Amebic X-cell pseudotumor Submitter: C. M. Morrison
RTLA 2291. Axolotl, Ambystoma mexicanum
Material: Portion of pliable, nodular right testis
Diagnosis: "Normal"
Submitter: R. Verhoeff-de Fremery
RTLA 2292. South African clawed frog, Xenopus laevis Material: Enlarged spleen
Diagnosis: "Normal"
Submitter: R. Verhoeff-de Fremery
RTLA 2293. Timor python. Python timoriensis
Material: Two microslides; hlstopathology report
Diagnosis: Well-differentiated mucinous adenocarcinoma with metastasis to spleen Submitter: E. Jacobson
RTLA 2294. False spiny hill turtle, Geoemyda sp.
Material: Three microslides; pathology report
Diagnosis: Disseminated mixed cell Ijrmphold reaction; stimulus unknown
Submitter: E. Jacobson and L. Kramer
RTLA 2295. Spider (possibly orb)
Material: Pecan tree leaflet with attached dried whole animal
Habitat: Southeast Fruit and Tree Nut Research Laboratory,
Byron, Georgia
Diagnosis: Fungus infection and sporulation
Submitter: W. L. Tedders
RTLA
2296. Burmese python. Python molorus Material: Three pieces of tissue
Diagnosis: Visceral mucoid adenocarcinoma — genital origin suspected
Submitter: S. Emanuelson
RTLA 2297. Northern gulf croaker, Micropogonias megalops Material: Three pieces of tissue
Habitat: Golfo de California, Sonora, Mexico
Diagnosis: Melanophoric neurilemmoma Submitter: L. T. Findley and A. J. Mearns
RTLA 2298. Croaker, Micropogonias altipinnis ?
Material: Piece of tissue from right cheek
Habitat: Golfo de California, Sonora, Mdxico
Diagnosis: Melanophoric neurilemmoma Submitter: L. T. Findley and A. J. Mearns
-17-
RTLA 2299. Grunt, Pomadasys ? macracanthus ?
Material: Wedge of tissue from interorbital area of head
Habitat: Golfo de California, Sonora, Mdxico
Diagnosis: Melanophoric neurilemmoma Submitter: L. T. Findley and A. J. Mearns
RTLA 2300. Rainbow trout, Salmo galrdneri
Material: One microslide; 1 color transparency
Habitat: Farmed rainbow trout; Tasmania
Diagnosis: Dysmorphogenic anomaly Submitter: B. L. Munday
RTLA 2301. Brown trout, Salmo trutta
Material: Three microslides; 2 color transparencies
Habitat: An Inland lake; Tasmania
Diagnosis: Well-differentiated leiomyoma Submitter: B. L. Munday
RTLA
2302. Brook trout, Salvelinus fontinalis Material: Four microslides
Habitat: Lafayette Hatchery, North Kingston,
Diagnosis: Subcutaneous fibroma
Submitter: A. George
Rhode Island